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Inhibitor Report for: SCHEMBL19358888

dual sEH/FAAH inhibitor human-EPHX2 IC50=3nM mouse-hyes IC50=2.1 nM human FAAH IC50=24nM mouse FAAH IC50=510nM


General
Type Urea derivative, Benzoate, FAAH inhibitor, Multitarget
Chemical_Nomenclature benzyl 4-[4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]cyclohexyl]oxybenzoate
Canonical SMILES C1CC(CCC1NC(=O)NC2=CC=C(C=C2)OC(F)(F)F)OC3=CC=C(C=C3)C(=O)OCC4=CC=CC=C4
InChI InChI=1S/C28H27F3N2O5/c29-28(30,31)38-25-16-10-22(11-17-25)33-27(35)32-21-8-14-24(15-9-21)37-23-12-6-20(7-13-23)26(34)36-18-19-4-2-1-3-5-19/h1-7,10-13,16-17,21,24H,8-9,14-15,18H2,(H2,32,33,35)
InChIKey IEOQZCMTPHDRLT-UHFFFAOYSA-N
Other name(s) compound 24
________________________________________________________________________________________________
MW|528.52
Formula|C28H27F3N2O5
CAS_number|
PubChem|130431481
UniChem|IEOQZCMTPHDRLT-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | SCHEMBL19358888 ligand of proteins in family: Epoxide_hydrolase
Protein | human-EPHX2, mouse-hyes

References:
Search PubMed for references concerning: SCHEMBL19358888
    Title: Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase
    Kodani SD, Bhakta S, Hwang SH, Pakhomova S, Newcomer ME, Morisseau C, Hammock BD
    Ref: Bioorganic & Medicinal Chemistry Lett, 28:762, 2018 : PubMed