SCHEMBL19421119
General
Type : Azaspiro,Azetidin
Chemical_Nomenclature : 2-[3-[(3-chloro-4-methylphenyl)methoxy]azetidine-1-carbonyl]-7-oxa-5-azaspiro[3.4]octan-6-one
Canonical SMILES : CC1=C(C=C(C=C1)COC2CN(C2)C(=O)C3CC4(C3)COC(=O)N4)Cl
InChI : InChI=1S\/C18H21ClN2O4\/c1-11-2-3-12(4-15(11)19)9-24-14-7-21(8-14)16(22)13-5-18(6-13)10-25-17(23)20-18\/h2-4,13-14H,5-10H2,1H3,(H,20,23)
InChIKey : AKBHYCHPWZPGAH-UHFFFAOYSA-N
Other name(s) : SCHEMBL19409503,SCHEMBL19409505
MW : 364.8
Formula : C18H21ClN2O4
CAS_number :
PubChem : 130475870
UniChem : AKBHYCHPWZPGAH-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : SCHEMBL19421119 ligand of proteins in family: Monoglyceridelipase_lysophospholip
Stucture : 7L50 Crystal structure of human monoacylglycerol lipase in complex with compound SCHEMBL19421119
Protein : human-MGLL
References (1)
| Title : Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl Moiety - Ikeda_2021_J.Med.Chem__ |
| Author(s) : Ikeda S , Sugiyama H , Tokuhara H , Murakami M , Nakamura M , Oguro Y , Aida J , Morishita N , Sogabe S , Dougan DR , Gay SC , Qin L , Arimura N , Takahashi Y , Sasaki M , Kamada Y , Aoyama K , Kimoto K , Kamata M |
| Ref : Journal of Medicinal Chemistry , : , 2021 |
| Abstract : Ikeda_2021_J.Med.Chem__ |
| ESTHER : Ikeda_2021_J.Med.Chem__ |
| PubMedSearch : Ikeda_2021_J.Med.Chem__ |
| PubMedID: 34328319 |
| Gene_locus related to this paper: human-MGLL |