TAM16
General
Type : Piperidine,Carboxamide,Benzofuran
Chemical_Nomenclature : 5-hydroxy-2-(4-hydroxyphenyl)-N-methyl-4-(piperidin-1-ylmethyl)-1-benzofuran-3-carboxamide
Canonical SMILES : CNC(=O)C1=C(OC2=C1C(=C(C=C2)O)CN3CCCCC3)C4=CC=C(C=C4)O
InChI : InChI=1S\/C22H24N2O4\/c1-23-22(27)20-19-16(13-24-11-3-2-4-12-24)17(26)9-10-18(19)28-21(20)14-5-7-15(25)8-6-14\/h5-10,25-26H,2-4,11-13H2,1H3,(H,23,27)
InChIKey : PQGCMFVNJWTUFH-UHFFFAOYSA-N
Other name(s) : GTPL9645,5V8,SCHEMBL18176915,5-hydroxy-2-(4-hydroxyphenyl)-N-methyl-4-(1-piperidylmethyl)benzofuran-3-carboxamide,5-hydroxy-2-(4-hydroxyphenyl)-N-methyl-4-(piperidin-1-ylmethyl)-1-benzofuran-3-carboxamide,2-(4-Hydroxyphenyl)-~{n}-Methyl-5-Oxidanyl-4-(Piperidin-1-Ylmethyl)-1-Benzofuran-3-Carboxamide
MW : 380.44
Formula : C22H24N2O4
CAS_number :
PubChem : 122644519
UniChem : PQGCMFVNJWTUFH-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : TAM16 ligand of proteins in family: Thioesterase
Stucture : 5V3Y Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM16
Protein : myctu-PKS13
References (1)
| Title : Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13 - Aggarwal_2017_Cell_170_249 |
| Author(s) : Aggarwal A , Parai MK , Shetty N , Wallis D , Woolhiser L , Hastings C , Dutta NK , Galaviz S , Dhakal RC , Shrestha R , Wakabayashi S , Walpole C , Matthews D , Floyd D , Scullion P , Riley J , Epemolu O , Norval S , Snavely T , Robertson GT , Rubin EJ , Ioerger TR , Sirgel FA , van der Merwe R , van Helden PD , Keller P , Bottger EC , Karakousis PC , Lenaerts AJ , Sacchettini JC |
| Ref : Cell , 170 :249 , 2017 |
| Abstract : Aggarwal_2017_Cell_170_249 |
| ESTHER : Aggarwal_2017_Cell_170_249 |
| PubMedSearch : Aggarwal_2017_Cell_170_249 |
| PubMedID: 28669536 |
| Gene_locus related to this paper: myctu-PKS13 |