Tacrine-Trolox-7u
General
Type : Multitarget,Antioxidant,Derivative of Tacrine,Carboxamide,Alkyl linked bis-ligand
Chemical_Nomenclature : N-[8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl]-6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromene-2-carboxamide
Canonical SMILES : CC1=C(C(=C2CCC(OC2=C1C)(C)C(=O)NCCCCCCCCNC3=C4CCCCC4=NC5=C3C=CC(=C5)Cl)C)O
InChI : InChI=1S\/C35H46ClN3O3\/c1-22-23(2)33-26(24(3)32(22)40)17-18-35(4,42-33)34(41)38-20-12-8-6-5-7-11-19-37-31-27-13-9-10-14-29(27)39-30-21-25(36)15-16-28(30)31\/h15-16,21,40H,5-14,17-20H2,1-4H3,(H,37,39)(H,38,41)
InChIKey : MATYDNFWBAVIBC-UHFFFAOYSA-N
Other name(s) : N-{8-[(6-Chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl}-6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-carboxamide,CHEMBL3632994,BDBM50133473
MW : 592.22
Formula : C35H46ClN3O3
CAS_number :
PubChem : 122194888
UniChem : MATYDNFWBAVIBC-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (1)
| Title : Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity - Nepovimova_2015_J.Med.Chem_58_8985 |
| Author(s) : Nepovimova E , Korabecny J , Dolezal R , Babkova K , Ondrejicek A , Jun D , Sepsova V , Horova A , Hrabinova M , Soukup O , Bukum N , Jost P , Muckova L , Kassa J , Malinak D , Andrs M , Kuca K |
| Ref : Journal of Medicinal Chemistry , 58 :8985 , 2015 |
| Abstract : Nepovimova_2015_J.Med.Chem_58_8985 |
| ESTHER : Nepovimova_2015_J.Med.Chem_58_8985 |
| PubMedSearch : Nepovimova_2015_J.Med.Chem_58_8985 |
| PubMedID: 26503905 |