Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: Tetracyclic-carbamate-cp8

IC50 hAChE 3.6 microM; IC50 hBChE 5.2 nM


General
Type PET probe, Carbamate, Natural_modified, Derivative of Evodiamine, Isoquinoline, Quinazoline
Chemical_Nomenclature 13-Methyl-5,8,13,13a-tetrahydro-6H-isoquinolino[1,2-b]quinazolin-10-yl (7-[18F]fluoroheptyl)carbamate
Canonical SMILES C12=C(C=CC=C1)C4N(CC2)CC3=CC(=CC=C3N4C)OC(=O)NCCCCCCCF
InChI InChI=1S/C25H32FN3O2/c1-28-23-12-11-21(31-25(30)27-15-8-4-2-3-7-14-26)17-20(23)18-29-16-13-19-9-5-6-10-22(19)24(28)29/h5-6,9-12,17,24H,2-4,7-8,13-16,18H2,1H3,(H,27,30)
InChIKey BRQIFYBESADBLA-UHFFFAOYSA-N
Other name(s) [18F]-UW-MD-95 ; 13-Methyl-5,8,13,13a-tetrahydro-6H-isoquinolino[1,2-b]quinazolin-10-yl (7-[18F]fluoroheptyl)carbamate {[18F]8}
________________________________________________________________________________________________
MW|425.54
Formula|C25H32FN3O2
CAS_number|
PubChem|
UniChem|BRQIFYBESADBLA-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Tetracyclic-carbamate-cp8 ligand of proteins in family: BCHE
Protein | human-BCHE

References:
Search PubMed for references concerning: Tetracyclic-carbamate-cp8
    Title: Selective Pseudo-irreversible Butyrylcholinesterase Inhibitors Transferring Antioxidant Moieties to the Enzyme Show Pronounced Neuroprotective Efficacy In Vitro and In Vivo in an Alzheimer's Disease Mouse Model
    Scheiner M, Hoffmann M, He F, Poeta E, Chatonnet A, Monti B, Maurice T, Decker M
    Ref: Journal of Medicinal Chemistry, 64(13)::9302, 2021 : PubMed

            

    Title: A Novel Way To Radiolabel Human Butyrylcholinesterase for Positron Emission Tomography through Irreversible Transfer of the Radiolabeled Moiety
    Sawatzky E, Al-Momani E, Kobayashi R, Higuchi T, Samnick S, Decker M
    Ref: ChemMedChem, 11:1540, 2016 : PubMed

            

    Title: Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer
    Darras FH, Kling B, Heilmann J, Decker M
    Ref: ACS Med Chem Lett, 3:914, 2012 : PubMed