Toluidine-Blue

Tolonium chloride is a phenothiazine that has been used as a hemostatic, a biological stain, and a dye for wool and silk. Tolonium chloride has also been used as a diagnostic aid for oral and gastric neoplasms and in the identification of the parathyroid gland in thyroid surgery

General

Type : Dye,Drug,Phenothiazine,Sulfur Compound

Chemical_Nomenclature : (7-amino-8-methylphenothiazin-3-ylidene)-dimethylazanium

Canonical SMILES : CC1=CC2=C(C=C1N)SC3=CC(=[N+](C)C)C=CC3=N2 || CC1=CC2=C(C=C1N)SC3=CC(=[N+](C)C)C=CC3=N2.[Cl-]

InChI : InChI=1S\/C15H15N3S\/c1-9-6-13-15(8-11(9)16)19-14-7-10(18(2)3)4-5-12(14)17-13\/h4-8,16H,1-3H3\/p+1 || InChI=1S\/C15H15N3S.ClH\/c1-9-6-13-15(8-11(9)16)19-14-7-10(18(2)3)4-5-12(14)17-13\;\/h4-8,16H,1-3H3\;1H

InChIKey : KZEUBCUXBNEMSQ-UHFFFAOYSA-O || GEDVVYWLPUPJJZ-UHFFFAOYSA-N

Other name(s) : Tolonium chloride,Toluidine Blue,Toluidine Blue O,Basic Blue 17,Blutene chloride,Tolonium,Tolonium cation,Tolonium ion,UNII-P3Y6XJA2D1,CHEBI:87648


MW : 305.82

Formula : C15H16ClN3S

CAS_number : 56109-24-1 || 92-31-9

PubChem : 7083, 7084

UniChem : KZEUBCUXBNEMSQ-UHFFFAOYSA-O || GEDVVYWLPUPJJZ-UHFFFAOYSA-N

IUPHAR :

Wikipedia :

Target

Families : Toluidine-Blue ligand of proteins in family: ACHE || BCHE

Stucture :

Protein : human-ACHE || human-BCHE

References (2)

Title : Toluidine blue O modifies hippocampal amyloid pathology in a transgenic mouse model of Alzheimer's disease - Yuksel_2018_Biochimie_146_105
Author(s) : Yuksel M , Biberoglu K , Onder S , Akbulut KG , Tacal O
Ref : Biochimie , 146 :105 , 2018
Abstract : Yuksel_2018_Biochimie_146_105
ESTHER : Yuksel_2018_Biochimie_146_105
PubMedSearch : Yuksel_2018_Biochimie_146_105
PubMedID: 29248542

Title : Toluidine blue O is a potent inhibitor of human cholinesterases - Biberoglu_2016_Arch.Biochem.Biophys_604_57
Author(s) : Biberoglu K , Tek MY , Ghasemi ST , Tacal O
Ref : Archives of Biochemistry & Biophysics , 604 :57 , 2016
Abstract : Biberoglu_2016_Arch.Biochem.Biophys_604_57
ESTHER : Biberoglu_2016_Arch.Biochem.Biophys_604_57
PubMedSearch : Biberoglu_2016_Arch.Biochem.Biophys_604_57
PubMedID: 27296777