Z-Ala_prolinal
General
Type : Benzyloxycarbonyl,Peptide,Pyrrolidine
Chemical_Nomenclature : (2S)-1-[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]pyrrolidine-2-carboxylic acid
Canonical SMILES : CC(C(=O)N1CCCC1C(=O)O)NC(=O)OCC2=CC=CC=C2
InChI : InChI=1S\/C16H20N2O5\/c1-11(14(19)18-9-5-8-13(18)15(20)21)17-16(22)23-10-12-6-3-2-4-7-12\/h2-4,6-7,11,13H,5,8-10H2,1H3,(H,17,22)(H,20,21)\/t11-,13-\/m0\/s1
InChIKey : RSSOZTMMMIWOJB-AAEUAGOBSA-N
Other name(s) : Z-Ala-Pro-OH,Z-Ala Prolinal,ZAH,AC1NTUQE,Benzyloxycarbonyl-alanyl-proline
MW : 320.34
Formula : C16H20N2O5
CAS_number : 21027-01-0
PubChem : 5388928
UniChem : RSSOZTMMMIWOJB-AAEUAGOBSA-N
IUPHAR :
Wikipedia :
Target
Families : Z-Ala_prolinal ligand of proteins in family: S9N_PPCE_Peptidase_S9
Stucture : 2BKL Prolyl endopeptidase from Myxococcus xanthus inhibited by Z-Ala_prolinal closed form
Protein : myxxa-PEP
References (2)
| Title : Effect of a prolyl endopeptidase inhibitor benzyloxycarbonyl-alanyl-proline on the development of experimental depressive syndrome in rats - Khlebnikova_2009_Bull.Exp.Biol.Med_147_291 |
| Author(s) : Khlebnikova NN , Krupina NA , Orlova IN , Bogdanova NG , Zolotov NN , Kryzhanovskii GN |
| Ref : Bulletin of Experimental Biology & Medicine , 147 :291 , 2009 |
| Abstract : Khlebnikova_2009_Bull.Exp.Biol.Med_147_291 |
| ESTHER : Khlebnikova_2009_Bull.Exp.Biol.Med_147_291 |
| PubMedSearch : Khlebnikova_2009_Bull.Exp.Biol.Med_147_291 |
| PubMedID: 19529846 |
| Title : Structural and mechanistic analysis of two prolyl endopeptidases: role of interdomain dynamics in catalysis and specificity - Shan_2005_Proc.Natl.Acad.Sci.U.S.A_102_3599 |
| Author(s) : Shan L , Mathews, II , Khosla C |
| Ref : Proc Natl Acad Sci U S A , 102 :3599 , 2005 |
| Abstract : Shan_2005_Proc.Natl.Acad.Sci.U.S.A_102_3599 |
| ESTHER : Shan_2005_Proc.Natl.Acad.Sci.U.S.A_102_3599 |
| PubMedSearch : Shan_2005_Proc.Natl.Acad.Sci.U.S.A_102_3599 |
| PubMedID: 15738423 |
| Gene_locus related to this paper: myxxa-PEP , sphca-Q9ZNM8 |