ZA
Potent Reversible inhibitor of insect AChE
General
Type : Acridine,Derivative of Tacrine
Chemical_Nomenclature : 1,2,3,4,-tetrahydro-N-(phenyl methyl)-9-acridinamine
Canonical SMILES : C1CCC2=NC3=CC=CC=C3C(=C2C1)NCC4=CC=CC=C4
InChI : InChI=1S\/C20H20N2\/c1-2-8-15(9-3-1)14-21-20-16-10-4-6-12-18(16)22-19-13-7-5-11-17(19)20\/h1-4,6,8-10,12H,5,7,11,13-14H2,(H,21,22)
InChIKey : JYJAEHAURXXPSD-UHFFFAOYSA-N
Other name(s) : 9-(3-Phenylmethylamino)-1,2,3,4-tetrahydroacridine,9-(3-Phenylmethylamino)-tacrine
MW : 288.386
Formula : C20H20N2
CAS_number :
PubChem : 1933
UniChem : JYJAEHAURXXPSD-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (2)
| Title : A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides - Nachon_2020_Molecules_25_1198 |
| Author(s) : Nachon F , Rosenberry TL , Silman I , Sussman JL |
| Ref : Molecules , 25 :1198 , 2020 |
| Abstract : Nachon_2020_Molecules_25_1198 |
| ESTHER : Nachon_2020_Molecules_25_1198 |
| PubMedSearch : Nachon_2020_Molecules_25_1198 |
| PubMedID: 32155891 |
| Gene_locus related to this paper: drome-ACHE |
| Title : Three-dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors - Harel_2000_Protein.Sci_9_1063 |
| Author(s) : Harel M , Kryger G , Rosenberry TL , Mallender WD , Lewis T , Fletcher RJ , Guss JM , Silman I , Sussman JL |
| Ref : Protein Science , 9 :1063 , 2000 |
| Abstract : Harel_2000_Protein.Sci_9_1063 |
| ESTHER : Harel_2000_Protein.Sci_9_1063 |
| PubMedSearch : Harel_2000_Protein.Sci_9_1063 |
| PubMedID: 10892800 |
| Gene_locus related to this paper: drome-ACHE |