mitoFP
mitoFP localize to the mitochondria via an appended triphenylphosphonium group, which delivers the probe to the mitochondria based on the electrochemical potential.
General
Type : Organophosphate
Chemical_Nomenclature : 4-[fluoro(octoxy)phosphoryl]butyl-triphenylphosphanium\;fluoride
Canonical SMILES : CCCCCCCCOP(=O)(CCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)F.[F-]
InChI : InChI=1S\/C30H40FO2P2.FH\/c1-2-3-4-5-6-16-25-33-35(31,32)27-18-17-26-34(28-19-10-7-11-20-28,29-21-12-8-13-22-29)30-23-14-9-15-24-30\;\/h7-15,19-24H,2-6,16-18,25-27H2,1H3\;1H\/q+1\;\/p-1
InChIKey : OMZNGJMDMWCXQP-UHFFFAOYSA-M
Other name(s) :
MW : 532.6
Formula : C30H40F2O2P2
CAS_number :
PubChem : 139033750
UniChem : OMZNGJMDMWCXQP-UHFFFAOYSA-M
IUPHAR :
Wikipedia :
Target
Families : mitoFP ligand of proteins in family: ABHD10 || LYsophospholipase_carboxylesterase
Stucture :
References (1)
| Title : ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5 - Cao_2019_Nat.Chem.Biol_15_1232 |
| Author(s) : Cao Y , Qiu T , Kathayat RS , Azizi SA , Thorne AK , Ahn D , Fukata Y , Fukata M , Rice PA , Dickinson BC |
| Ref : Nat Chemical Biology , 15 :1232 , 2019 |
| Abstract : Cao_2019_Nat.Chem.Biol_15_1232 |
| ESTHER : Cao_2019_Nat.Chem.Biol_15_1232 |
| PubMedSearch : Cao_2019_Nat.Chem.Biol_15_1232 |
| PubMedID: 31740833 |
| Gene_locus related to this paper: human-ABHD10 , mouse-abhda |