Gene Locus : human-BCHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : OP-resistance Zhang_2012_J.Pharmacol.Exp.Ther_343_673
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : OP-resistance
Torpedo_number : 199
Kinetic Parameter : No kinetic parameter
News : No news
Comment : p.E197C Glu197Cys (p.E225C Glu225Cys in primary sequence with 28 amino-acids signal peptide) OP-resistance
Title : Identification of Human Butyrylcholinesterase Organophosphate-Resistant Variants through a Novel Mammalian Enzyme Functional Screen - Zhang_2012_J.Pharmacol.Exp.Ther_343_673 |
Author(s) : Zhang J , Chen S , Ralph EC , Dwyer MA , Cashman JR |
Ref : Journal of Pharmacology & Experimental Therapeutics , 343 :673 , 2012 |
Abstract : Zhang_2012_J.Pharmacol.Exp.Ther_343_673 |
ESTHER : Zhang_2012_J.Pharmacol.Exp.Ther_343_673 |
PubMedSearch : Zhang_2012_J.Pharmacol.Exp.Ther_343_673 |
PubMedID: 22956723 |