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Mutation Report for: E389Q_human-ACHE

E389Q_human-ACHE
Gene_Locus|human-ACHE
Mode of mutation|Site directed mutagenesis
Amino Acid change|E389Q
Torpedo number|382
Summary|
Comment|p.E389Q Glu389Gln (p.E420Q Glu420Gln in primary sequence with 31 amino-acids signal peptide) Electrostatic attraction hypothesis: minor effect on catalysis
Kinetic parameters|3,3-dimethylbutylthioacetate_E389Q_human-ACHE,
Acetylthiocholine_E389Q_human-ACHE,
Edrophonium_E389Q_human-ACHE


References:
    Title: Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase
    Shafferman A, Ordentlich A, Barak D, Kronman C, Ber R, Bino T, Ariel N, Osman R, Velan B
    Ref: EMBO Journal, 13:3448, 1994 : PubMed

            




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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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