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Mutation Report for: G115E_human-BCHE

G115E_human-BCHE
Gene_Locus|human-BCHE
Mode of mutation|Site directed mutagenesis
Amino Acid change|G115E
Torpedo number|117
Summary|
Comment|p.G115E Gly115Glu (p.G143E Gly143Glu in primary sequence with 28 amino-acids signal peptide) Oxyanion hole;significant reduction of activity
Kinetic parameters|Butyrylthiocholine_G115E_human-BCHE


References:
    Title: Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis
    Loewenstein-Lichtenstein Y, Glick D, Gluzman N, Sternfeld M, Zakut H, Soreq H
    Ref: Molecular Pharmacology, 50:1423, 1996 : PubMed

            




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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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