Mutation

Kinetic parameters

Tree Display

AceDB Schema

XML Display

Feedback

Mutation Report for: G117K_human-BCHE

G117K_human-BCHE
Gene_Locus|human-BCHE
Mode of mutation|Site directed mutagenesis
Amino Acid change|G117K
Torpedo number|119
Summary|
Comment|p.G117K Gly117Lys (p.G145K Gly145Lys in primary sequence with 28 amino-acids signal peptide) Phosphotriesterase activity OP sensitive
Kinetic parameters|none


References:
    Title: Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: design, construction and characterization
    Broomfield CA, Lockridge O, Millard CB
    Ref: Chemico-Biological Interactions, 119-120:413, 1999 : PubMed

            

    Title: Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanase
    Millard CB, Lockridge O, Broomfield CA
    Ref: Biochemistry, 37:237, 1998 : PubMed

            

    Title: Design and expression of organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase
    Millard CB, Lockridge O, Broomfield CA
    Ref: Biochemistry, 34:15925, 1995 : PubMed

            




Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer