Gene Locus : human-BCHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Acyl specificity Acyl pocket, low activity km X 5 for BTC Gnatt_1994_J.Neurochem_62_749 || Acyl specificity Acyl pocket, low activity km X 20 to 50 for ATC PTC BTC and BzCH Boeck_2002_Biochem.Pharmacol_63_2101 || Acyl specificity Acyl pocket R286 responsible for resistance to inhibition by Triton X-100 Boeck_2002_Biochem.Pharmacol_63_2101 || Binding of Triton X-100 studies Acyl pocket R286 responsible for resistance to inhibition by Triton X-100 Boeck_2002_Biochem.Pharmacol_63_2101
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Acyl specificity || Binding of Triton X-100 studies
Torpedo_number : 288
Kinetic Parameter : Butyrylthiocholine_L286R_human-BCHE
News : No news
Comment : p.L286R Leu286Arg (p.L314R Leu314Arg in primary sequence with 28 amino-acids signal peptide), Acyl pocket: low activity km X 5 for BTC, km X 20 to 50 for ATC PTC BTC and BzCH, Acyl pocket R286 responsible for resistance to inhibition by Triton X-100
| Title : DNA sequence of butyrylcholinesterase from the rat: expression of the protein and characterization of the properties of rat butyrylcholinesterase - Boeck_2002_Biochem.Pharmacol_63_2101 |
| Author(s) : Boeck AT , Schopfer LM , Lockridge O |
| Ref : Biochemical Pharmacology , 63 :2101 , 2002 |
| Abstract : Boeck_2002_Biochem.Pharmacol_63_2101 |
| ESTHER : Boeck_2002_Biochem.Pharmacol_63_2101 |
| PubMedSearch : Boeck_2002_Biochem.Pharmacol_63_2101 |
| PubMedID: 12110369 |
| Gene_locus related to this paper: ratno-BCHE |
| Title : Site-directed mutagenesis of active site residues reveals plasticity of human butyrylcholinesterase in substrate and inhibitor interactions - Gnatt_1994_J.Neurochem_62_749 |
| Author(s) : Gnatt A , Loewenstein Y , Yaron A , Schwarz M , Soreq H |
| Ref : Journal of Neurochemistry , 62 :749 , 1994 |
| Abstract : Gnatt_1994_J.Neurochem_62_749 |
| ESTHER : Gnatt_1994_J.Neurochem_62_749 |
| PubMedSearch : Gnatt_1994_J.Neurochem_62_749 |
| PubMedID: 8294937 |