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Mutation Report for: W430A_human-BCHE

W430A_human-BCHE
Gene_Locus|human-BCHE
Mode of mutation|Site directed mutagenesis
Amino Acid change|W430A
Torpedo number|432
Summary|
Comment|p.W430A Trp430Ala (p.W458A Trp458Ala in primary sequence with 28 amino-acids signal peptide) stabilisation of Omega loop, retained substrate activation
Kinetic parameters|none


References:
    Title: Effects of mutations of active site residues and amino acids interacting with the Omega loop on substrate activation of butyrylcholinesterase
    Masson P, Xie W, Froment MT, Lockridge O
    Ref: Biochimica & Biophysica Acta, 1544:166, 2001 : PubMed

            




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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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