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Mutation Report for: Y124Q_human-ACHE

Y124Q_human-ACHE
Gene_Locus|human-ACHE
Mode of mutation|Site directed mutagenesis
Amino Acid change|Y124Q
Torpedo number|121
Summary|
Comment|Y124Q p.Tyr124Gln (Y155Q p.Tyr155Gln in primary sequence with 31 amino-acids signal peptide) Acyl specificity;replacement of aromatic active center residues in human-ACHE by the corresponding residues in human-BCHE
Kinetic parameters|Acetylthiocholine_Y124Q_human-ACHE,
Butyrylthiocholine_Y124Q_human-ACHE


References:
    Title: Does butyrylization of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase?
    Kaplan D, Ordentlich A, Barak D, Ariel N, Kronman C, Velan B, Shafferman A
    Ref: Biochemistry, 40:7433, 2001 : PubMed

            




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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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