Paper Report for: Ahern_2002_Trends.Neurosci_25_510
Reference
Title: cGMP and S-nitrosylation: two routes for modulation of neuronal excitability by NO Ahern GP, Klyachko VA, Jackson MB Ref: Trends in Neurosciences, 25:510, 2002 : PubMed
The nitric oxide (NO)-cGMP signaling cascade has been implicated in synaptic plasticity and, more broadly, in the control of many forms of electrical activity. This raises the issue of how these second messengers regulate ion channels. The field of ion-channel modulation is dominated by G proteins; NO and cGMP are often treated as poor cousins. However, recent advances surveyed here could change this perception. A surprising new dimension to NO signaling is the direct cGMP-independent action of NO on channel proteins through S-nitrosylation. The existence of two effector pathways has important functional implications, expanding and enriching the possibilities for modulating neuronal excitability.
        
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Ahern GP, Klyachko VA, Jackson MB (2002) cGMP and S-nitrosylation: two routes for modulation of neuronal excitability by NO Trends in Neurosciences25: 510-7
Ahern GP, Klyachko VA, Jackson MB (2002) Trends in Neurosciences25: 510-7