Paper Report for: de la Torre_2002_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_131_271
Reference
Title: Freshwater pollution biomarker: response of brain acetylcholinesterase activity in two fish species de la Torre FR, Ferrari L, Salibian A Ref: Comparative Biochemistry & Physiology C Toxicol Pharmacol, 131:271, 2002 : PubMed
The effect of prolonged exposure at two sites along the Reconquista River (Argentina), a highly polluted peri-urban water body, on brain acetylcholinesterase (AChE, EC 3.1.1.7, acetylcholine acetylhydrolase) of two teleosts was examined. Caged Cyprinus carpio and field-captured Cnesterodon decemmaculatus were used as sentinel organisms. Eserine concentration inhibiting 50% of AChE activity (IC50) and inhibition kinetic parameters were also evaluated. Interspecies IC50 differences were found to agree with observed kinetic parameters (KA, ki and kc), indicating that carps were more sensitive to eserine. Data obtained disclosed spatial differences and demonstrated the high sensitivity of AChE activity as an exposure biomarker. Marked species-related differences were detected, showing that enzyme determination of C. decemmaculatus is more effective in highly polluted sites. Considering the river water physicochemical profile, observed changes in AChE activities can be partly attributed to long-lasting raised concentrations of dissolved heavy metals.
        
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de la Torre FR, Ferrari L, Salibian A (2002) Freshwater pollution biomarker: response of brain acetylcholinesterase activity in two fish species Comparative Biochemistry & Physiology C Toxicol Pharmacol131: 271-80
de la Torre FR, Ferrari L, Salibian A (2002) Comparative Biochemistry & Physiology C Toxicol Pharmacol131: 271-80