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Reactivator Report for: K344

General
Type Bispyridinium
Chemical_Nomenclature 1-(9-pyridin-1-ium-1-ylnonyl)pyridin-1-ium;dibromide
Canonical SMILES C1=CC=[N+](C=C1)CCCCCCCCC[N+]2=CC=CC=C2.[Br-].[Br-]
InChI InChI=1S/C19H28N2.2BrH/c1(2-4-8-14-20-16-10-6-11-17-20)3-5-9-15-21-18-12-7-13-19-21;;/h6-7,10-13,16-19H,1-5,8-9,14-15H2;2*1H/q+2;;/p-2
InChIKey UOOOOWOODBZUKX-UHFFFAOYSA-L
Other name(s) K-344 ; 1,9-bis(pyridinium)-nonane dibromide ; CHEMBL105742 ; SCHEMBL3591238 ; UOOOOWOODBZUKX-UHFFFAOYSA-L ; N,N'-Nonane-1,9-diyl-bis-pyridinium Dibromide
________________________________________________________________________________________________
MW|444.25
Formula|C19H28Br2N2
CAS_number|
PubChem|11408144
UniChem|UOOOOWOODBZUKX-UHFFFAOYSA-L
IUPHAR|
Wikipedia|

Target

References:
Search PubMed for references concerning: K344

1 more
    Title: Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings
    Kuca K, Karasova JZ, Soukup O, Kassa J, Novotna E, Sepsova V, Horova A, Pejchal J, Hrabinova M and Musilek K <4 more author(s)>
    Ref: Drug Des Devel Ther, 12:505, 2018 : PubMed

            

    Title: A comparison of the efficacy of newly developed reversible inhibitors of acetylcholinesterase with commonly used pyridostigmine as pharmacological pre-treatment of soman-poisoned mice
    Kassa J, Musilek K, Koomlova M, Bajgar J
    Ref: Basic Clin Pharmacol Toxicol, 110:322, 2012 : PubMed

            

    Title: Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications
    Musilek K, Komloova M, Zavadova V, Holas O, Hrabinova M, Pohanka M, Dohnal V, Nachon F, Dolezal M and Jung YS <1 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, 20:1763, 2010 : PubMed

            


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