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Structure Report for: 1EK2

Name|Mouse epoxyde hydrolase complexed with Cdu inhibitor
Revelation date|31-May-2000
Family|Epoxide_hydrolase: there are 1166 genes in this family, 171 structure(s)
Gene_locus|mouse-hyes
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Only the C-terminal part (from aa 226)of the protein has the alpha/beta hydrolase fold. The N terminal part is alpha/beta Rossmann-fold related to L-2-Haloacid dehalogenase, HAD
Ligand|Inhibitor: CDU Ligand in structure: Ligplot


Reference

    Title: Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase
    Argiriadi MA, Morisseau C, Hammock BD, Christianson DW
    Ref: Proceedings of the National Academy of Sciences of the United States of America, 96:10637, 1999 : PubMed

            



Representative scheme of Epoxide_hydrolase structure and an image from PDBsum server

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Databases

PDB-Sum1EK2 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP1EK2 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP1EK2 Structural Classification Of Protein - SCOP server
PROTEOPEDIA1ek2 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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