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Structure Report for: 2P8S

Name|Human dipeptidyl peptidase IV/CD26 in complex with a cyclohexalamine inhibitor
Revelation date|22-May-2007
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 182 structure(s)
Gene_locus|human-DPP4
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Scapin, G., Biftu, T.
Ligand|Inhibitor: CHEMBL233360 Ligand in structure: Ligplot


Reference

    Title: Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin
    Biftu T, Scapin G, Singh S, Feng D, Becker JW, Eiermann G, He H, Lyons K, Patel S and Weber AE <7 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, 17:3384, 2007 : PubMed

            



Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

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Databases

PDB-Sum2P8S Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP2P8S Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP2P8S Structural Classification Of Protein - SCOP server
PROTEOPEDIA2p8s 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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