A new series of DPP-4 inhibitors derived from piperidine-fused benzimidazoles and imidazopyridines is described. Optimization of this class of DPP-4 inhibitors led to the discovery of imidazopyridine 34. The potency, selectivity, cross-species DMPK profiles, and in vivo efficacy of 34 is reported.
        
Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server
no Image
Databases
PDB-Sum
3HAB Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP
3HABFold classification based on Structure-Structure alignment of Proteins - FSSP server