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Structure Report for: 5HQ3

Name|Human acetylcholinesterase designed variant expressed in bacteria
Revelation date|27-Jul-2016
Family|ACHE: there are 546 genes in this family, 315 structure(s)
Gene_locus|human-ACHE
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Goldenzweig, A., Goldsmith, M., Hill, S.E., Gertman, O., Laurino, P.,
Ashani, Y., Dym, O., Albeck, S., Unger, T., Prilusky, J., Lieberman, R.L.,
Aharoni, A., Silman, I., Sussman, J.L., Tawfik, D.S., Fleishman, S.J. (51 substitutions)
(V12T,K23T,M42V,L48R,V60W,S67N,E91N,T109K,S110N,T112A,L115M,A127S,Q140R,A141T,
T144V,V187I,V226I,G234A,T238Y,G240S,M241R,G242E,T249L,H253K,T275N,A278P,
V280E,S309P,A318N,H322K,V331N,Q325D,A357E,A361E,V378I,R393K,L394N,E396D,V408I,
L414F,G416Q,L418Y,Q421N,A434S,S438P,L441E,A467K,Q474R,G506D,A507E,Q509K)
>5HQ3
MEGREDAELLVTTRGGRLRGIRLTTPGGPVSAFLGIPFAEPPVGPRRFRPPEPKQPWSGVWDATTFQNVCYQYVDTLYPG
FEGTEMWNPNRNLSEDCLYLNVWTPYPRPKNPAPVMVWIYGGGFYSGSSSLDVYDGRFLVRTERVVLVSMNYRVGAFGFL
ALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAILQSGAPNAPWAYV
SREEARRRALQLAKLVGCPPGGTGGNDTELVACLRNRPPQELVNHEWHVLPQESVFRFSFVPVVDGDFLPDTPEALINNG
DFKGLDVLVGVNKDEGSYFLVYGAPGFSKDNESLISREEFLEGVRVGVPQVSDLAAEAIVLHYTDWLHPEDPAKNRDALS
DVVGDHNVICPVAQFAQRYAANGARVYAYVFEHRSSTLPWPEWMGVPHGYEIEFIFGIPLDPSRNYTKEEKIFARRLMRY
WANFARTGDPNEPRDPKAPQWPPYTADEQKYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLD
Ligand|Inhibitor: VX Ligand in structure: Ligplot


Reference

    Title: Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability
    Goldenzweig A, Goldsmith M, Hill SE, Gertman O, Laurino P, Ashani Y, Dym O, Unger T, Albeck S and Fleishman SJ <6 more author(s)>
    Ref: Mol Cell, 63:337, 2016 : PubMed

            



Representative scheme of ACHE structure and an image from PDBsum server



Databases

PDB-Sum5HQ3 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP5HQ3 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP5HQ3 Structural Classification Of Protein - SCOP server
PROTEOPEDIA5hq3 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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