7PRM
Name : Crystal structure of human monoglyceride lipase with compound 13, YH149
Revelation date : 16-Feb-2022
Family : Monoglyceridelipase_lysophospholip
Gene_locus : human-MGLL
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Grether, U.,Gobbi, L.,Kuhn, B.,Collin, L.,Leibrock, L.,Heer, D.,Wittwer, M.,Benz, J. || (PET) scans, (R)-[18F]13 ((R)-[18F]YH149) showed a heterogeneous distribution and matched the MAGL expression pattern in the mouse brain
Ligand :
References (1)
| Title : Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging - He_2022_J.Med.Chem_65_2191 |
| Author(s) : He Y , Schild M , Grether U , Benz J , Leibrock L , Heer D , Topp A , Collin L , Kuhn B , Wittwer M , Keller C , Gobbi LC , Schibli R , Mu L |
| Ref : Journal of Medicinal Chemistry , 65 :2191 , 2022 |
| Abstract : He_2022_J.Med.Chem_65_2191 |
| ESTHER : He_2022_J.Med.Chem_65_2191 |
| PubMedSearch : He_2022_J.Med.Chem_65_2191 |
| PubMedID: 35089028 |
| Gene_locus related to this paper: human-MGLL |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
