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Substrate Report for: Florfenicol

A synthetic veterinary antibiotic closqe to chloramphenicol, that is used for treatment of bovine respiratory disease and foot rot; also used in aquaculture


General
Type Antibiotic, Sulfonyl, Sulfur compound
Chemical_Nomenclature 2,2-dichloro-~{N}-[(1~{R},2~{S})-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
Canonical SMILES CS(=O)(=O)C1=CC=C(C=C1)C(C(CF)NC(=O)C(Cl)Cl)O
InChI InChI=1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1
InChIKey AYIRNRDRBQJXIF-NXEZZACHSA-N
Other name(s) Nuflor ; (-)-Florfenicol ; Sch-25298 ; 3-fluorothiamphenicol ; chloramphen ; florphenicol ; Sch 25298 ; thiamphenicol, 3-fluoro
________________________________________________________________________________________________
MW|358.20
Formula|C12H14Cl2FNO4S
CAS_number|73231-34-2, 76639-94-6
PubChem|114811
UniChem|AYIRNRDRBQJXIF-NXEZZACHSA-N
IUPHAR|
Wikipedia|

Target
Families | Florfenicol ligand of proteins in family: Hormone-sensitive_lipase_like
Protein | 9bact-g3cr02

References:
Search PubMed for references concerning: Florfenicol
    Title: Crystal structure of chloramphenicol-metabolizing enzyme EstDL136 from a metagenome
    Kim SH, Kang PA, Han K, Lee SW, Rhee S
    Ref: PLoS ONE, 14:e0210298, 2019 : PubMed

            

    Title: Inactivation of chloramphenicol and florfenicol by a novel chloramphenicol hydrolase
    Tao W, Lee MH, Wu J, Kim NH, Kim JC, Chung E, Hwang EC, Lee SW
    Ref: Applied Environmental Microbiology, 78:6295, 2012 : PubMed

            

    Title: Characterization of two metagenome-derived esterases that reactivate chloramphenicol by counteracting chloramphenicol acetyltransferase
    Tao W, Lee MH, Yoon MY, Kim JC, Malhotra S, Wu J, Hwang EC, Lee SW
    Ref: J Microbiol Biotechnol, 21:1203, 2011 : PubMed