Fluostatin-C
General
Type : Epoxide
Chemical_Nomenclature : (3R,4S,6S)-3,10,13-trihydroxy-6-methyl-5-oxapentacyclo[9.7.0.02,8.04,6.012,17]octadeca-1,8,10,12(17),13,15-hexaene-7,18-dione
Canonical SMILES : CC12C(O1)C(C3=C4C(=C(C=C3C2=O)O)C5=C(C4=O)C=CC=C5O)O
InChI : InChI=1S\/C18H12O6\/c1-18-16(23)7-5-9(20)12-10-6(3-2-4-8(10)19)14(21)13(12)11(7)15(22)17(18)24-18\/h2-5,15,17,19-20,22H,1H3\/t15-,17+,18-\/m1\/s1
InChIKey : CXDDSWUAYSPFRJ-BPQIPLTHSA-N
Other name(s) : Fluostatin C, Fluostatins C, CHEMBL2164974
MW : 324.3
Formula : C18H12O6
CAS_number :
PubChem :
UniChem :
Iuphar :
Target
Families : CFTR-inhibitory-factor_Cif
References (2)
| Title : Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the alpha\/beta-fold epoxide hydrolase Alp1U - Zhang_2020_J.Biol.Chem_295_16987 |
| Author(s) : Zhang L , De BC , Zhang W , Mandi A , Fang Z , Yang C , Zhu Y , Kurtan T , Zhang C |
| Ref : Journal of Biological Chemistry , 295 :16987 , 2020 |
| Abstract : Zhang_2020_J.Biol.Chem_295_16987 |
| ESTHER : Zhang_2020_J.Biol.Chem_295_16987 |
| PubMedSearch : Zhang_2020_J.Biol.Chem_295_16987 |
| PubMedID: 33004437 |
| Gene_locus related to this paper: stram-q1rqu8 |
| Title : Fluostatins C-E, novel members of the fluostatin family produced by Streptomyces strain Acta 1383 - Baur_2006_J.Antibiot.(Tokyo)_59_293 |
| Author(s) : Baur S , Niehaus J , Karagouni AD , Katsifas EA , Chalkou K , Meintanis C , Jones AL , Goodfellow M , Ward AC , Beil W , Schneider K , Sussmuth RD , Fiedler HP |
| Ref : J Antibiot (Tokyo) , 59 :293 , 2006 |
| Abstract : Baur_2006_J.Antibiot.(Tokyo)_59_293 |
| ESTHER : Baur_2006_J.Antibiot.(Tokyo)_59_293 |
| PubMedSearch : Baur_2006_J.Antibiot.(Tokyo)_59_293 |
| PubMedID: 16883779 |