Naproxen
General
Type : Drug || Naphthalen
Chemical_Nomenclature : (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
Canonical SMILES : CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O
InChI : InChI=1S\/C14H14O3\/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10\/h3-9H,1-2H3,(H,15,16)\/t9-\/m0\/s1
InChIKey : CMWTZPSULFXXJA-VIFPVBQESA-N
Other name(s) : (S)-Naproxen, (R)-Naproxen, (+)-Naproxen, Naprosyn, NPX, NPS, CHEBI:7476, CHEMBL154, SCHEMBL3046, ZINC105216, DB00788
Target
Families : 6_AlphaBeta_hydrolase, Canar_LipB, Lipase_3, Hormone-sensitive_lipase_like
References (10)
| Title : Biochemical and Structural Characterization of a novel thermophilic esterase EstD11 provide catalytic insights for the HSL family - Miguel-Ruano_2021_Comput.Struct.Biotechnol.J_19_1214 |
| Author(s) : Miguel-Ruano V , Rivera I , Rajkovic J , Knapik K , Torrado A , Otero JM , Beneventi E , Becerra M , Sanchez-Costa M , Hidalgo A , Berenguer J , Gonzalez-Siso MI , Cruces J , Rua ML , Hermoso JA |
| Ref : Comput Struct Biotechnol J , 19 :1214 , 2021 |
| Abstract : Miguel-Ruano_2021_Comput.Struct.Biotechnol.J_19_1214 |
| ESTHER : Miguel-Ruano_2021_Comput.Struct.Biotechnol.J_19_1214 |
| PubMedSearch : Miguel-Ruano_2021_Comput.Struct.Biotechnol.J_19_1214 |
| PubMedID: 33680362 |
| Gene_locus related to this paper: 9delt-EstD11 |
| Title : Enhanced Production of (S)-2-arylpropionic Acids by Protein Engineering and Whole-Cell Catalysis - Liu_2021_Front.Bioeng.Biotechnol_9_697677 |
| Author(s) : Liu X , Zhao M , Fan X , Fu Y |
| Ref : Front Bioeng Biotechnol , 9 :697677 , 2021 |
| Abstract : Liu_2021_Front.Bioeng.Biotechnol_9_697677 |
| ESTHER : Liu_2021_Front.Bioeng.Biotechnol_9_697677 |
| PubMedSearch : Liu_2021_Front.Bioeng.Biotechnol_9_697677 |
| PubMedID: 34307324 |
| Gene_locus related to this paper: 9zzzz-Est924 |
| Title : Crystal structures of two Bacillus carboxylesterases with different enantioselectivities - Rozeboom_2014_Biochim.Biophys.Acta_1844_567 |
| Author(s) : Rozeboom HJ , Godinho LF , Nardini M , Quax WJ , Dijkstra BW |
| Ref : Biochimica & Biophysica Acta , 1844 :567 , 2014 |
| Abstract : Rozeboom_2014_Biochim.Biophys.Acta_1844_567 |
| ESTHER : Rozeboom_2014_Biochim.Biophys.Acta_1844_567 |
| PubMedSearch : Rozeboom_2014_Biochim.Biophys.Acta_1844_567 |
| PubMedID: 24418394 |
| Gene_locus related to this paper: bacsu-cbxnp , bacsu-ybfk |
| Title : Residue Val237 is critical for the enantioselectivity of Penicillium expansum lipase - Tang_2014_Biotechnol.Lett_36_633 |
| Author(s) : Tang L , Su M , Chi L , Zhang J , Zhang H , Zhu L |
| Ref : Biotechnol Lett , 36 :633 , 2014 |
| Abstract : Tang_2014_Biotechnol.Lett_36_633 |
| ESTHER : Tang_2014_Biotechnol.Lett_36_633 |
| PubMedSearch : Tang_2014_Biotechnol.Lett_36_633 |
| PubMedID: 24338160 |
| Gene_locus related to this paper: penex-Q9HFW6 |
| Title : Substitution of Val72 residue alters the enantioselectivity and activity of Penicillium expansum lipase - Tang_2013_World.J.Microbiol.Biotechnol_29_145 |
| Author(s) : Tang L , Su M , Zhu L , Chi L , Zhang J , Zhou Q |
| Ref : World J Microbiol Biotechnol , 29 :145 , 2013 |
| Abstract : Tang_2013_World.J.Microbiol.Biotechnol_29_145 |
| ESTHER : Tang_2013_World.J.Microbiol.Biotechnol_29_145 |
| PubMedSearch : Tang_2013_World.J.Microbiol.Biotechnol_29_145 |
| PubMedID: 22972595 |
| Gene_locus related to this paper: penex-Q9HFW6 |
| Title : Immobilization of Candida rugosa lipase on glass beads for enantioselective hydrolysis of racemic naproxen methyl ester - Yilmaz_2011_Bioresour.Technol_102_499 |
| Author(s) : Yilmaz E , Can K , Sezgin M , Yilmaz M |
| Ref : Bioresour Technol , 102 :499 , 2011 |
| Abstract : Yilmaz_2011_Bioresour.Technol_102_499 |
| ESTHER : Yilmaz_2011_Bioresour.Technol_102_499 |
| PubMedSearch : Yilmaz_2011_Bioresour.Technol_102_499 |
| PubMedID: 20846857 |
| Gene_locus related to this paper: canru-1lipa |
| Title : Efficient production of (S)-naproxen with (R)-substrate recycling using an overexpressed carboxylesterase BsE-NP01 - Liu_2010_Appl.Biochem.Biotechnol_162_1574 |
| Author(s) : Liu X , Xu JH , Pan J , Zhao J |
| Ref : Appl Biochem Biotechnol , 162 :1574 , 2010 |
| Abstract : Liu_2010_Appl.Biochem.Biotechnol_162_1574 |
| ESTHER : Liu_2010_Appl.Biochem.Biotechnol_162_1574 |
| PubMedSearch : Liu_2010_Appl.Biochem.Biotechnol_162_1574 |
| PubMedID: 20237863 |
| Gene_locus related to this paper: bacsu-cbxnp |
| Title : Lipase-catalyzed esterification of (S)-naproxen ethyl ester in supercritical carbon dioxide - Kwon_2009_J.Microbiol.Biotechnol_19_1596 |
| Author(s) : Kwon CH , Lee JH , Kim SW , Kang JW |
| Ref : J Microbiol Biotechnol , 19 :1596 , 2009 |
| Abstract : Kwon_2009_J.Microbiol.Biotechnol_19_1596 |
| ESTHER : Kwon_2009_J.Microbiol.Biotechnol_19_1596 |
| PubMedSearch : Kwon_2009_J.Microbiol.Biotechnol_19_1596 |
| PubMedID: 20075625 |
| Gene_locus related to this paper: canar-LipB |
| Title : Hydrolytic resolution of (R,S)-naproxen 2,2,2-trifluoroethyl thioester by Carica papaya lipase in water-saturated organic solvents - Ng_2005_Biotechnol.Bioeng_89_88 |
| Author(s) : Ng IS , Tsai SW |
| Ref : Biotechnol Bioeng , 89 :88 , 2005 |
| Abstract : Ng_2005_Biotechnol.Bioeng_89_88 |
| ESTHER : Ng_2005_Biotechnol.Bioeng_89_88 |
| PubMedSearch : Ng_2005_Biotechnol.Bioeng_89_88 |
| PubMedID: 15543625 |
| Title : Lipase-catalyzed naproxen methyl ester hydrolysis in water-saturated ionic liquid: significantly enhanced enantioselectivity and stability - Xin_2005_World.J.Microbiol.Biotechnol_21_193 |
| Author(s) : Xin JY , Zhao YJ , Shi YG , Xia CG , Li SB |
| Ref : World J Microbiol Biotechnol , 21 :193 , 2005 |
| Abstract : Xin_2005_World.J.Microbiol.Biotechnol_21_193 |
| ESTHER : Xin_2005_World.J.Microbiol.Biotechnol_21_193 |
| PubMedSearch : Xin_2005_World.J.Microbiol.Biotechnol_21_193 |
| PubMedID: |