Type Inhibitor

Tree Display

AceDB Schema

XML Display

Feedback

Type_inhibitor Report for: Trifluoro

Building block for many synthetic inhibitors of enzymes. The trifluoromethyl group is a functional group that has the formula -CF3. The naming of is group is derived from the methyl group (which has the formula -CH3). The trifluoromethyl group is often used as a bioisostere to create derivatives by replacing a chloride or a methyl group. This can be used to adjust the steric and electronic properties of a lead compound, or to protect a reactive methyl group from metabolic oxidation.

InhibitorMain targeted enzyme familiesTypeStructure
3-amino-4-phenyl-pyrrolidine-15BDPP4N_Peptidase_S9 Pyridine | Pyrimidine | Pyrrolidine | Trifluoro
5ALR-8TMEpoxide_hydrolase Quinazoline | Sulfur Compound | Trifluoro
5LP1-71HPAF-Acetylhydrolase Pyrimidine | Sulfur Compound | Trifluoro
62-mEHEpoxide_hydrolase Sulfur Compound | Trifluoro
6AX1-cp3Monoglyceridelipase_lysophospholip Azetidin | Carbamate | Halo ketone | Oxadiazol | Trifluoro
6M07-BWOPAF-Acetylhydrolase Pyrrolidine | Trifluoro
6M08-BWLPAF-Acetylhydrolase Pyrrolidine | Trifluoro
6N3Z-4Epoxide_hydrolase Trifluoro | Urea derivative
ABD-1970Monoglyceridelipase_lysophospholip Azabicyclo | Carbamate | Piperazine | Trifluoro
ABD957ABHD17-depalmitoylase Azabicyclo | Piperazine | Pyrazole | Sulfonamide | Sulfur Compound | Trifluoro
ABT-341DPP4N_Peptidase_S9 Triazol | Trifluoro
ABX-1431Monoglyceridelipase_lysophospholip Carbamate | Piperazine | Pyrrolidine | Trifluoro
ARUK3000223Pectinacetylesterase-Notum Fragment inhibitor of Notum | Triazol | Trifluoro
ARUK3000438Pectinacetylesterase-Notum Fragment inhibitor of Notum | Triazol | Trifluoro
ARUK3001043Pectinacetylesterase-Notum Fragment inhibitor of Notum | Triazol | Trifluoro
ARUK3001185Pectinacetylesterase-Notum Triazol | Trifluoro
ARUK3003909Pectinacetylesterase-Notum Fragment inhibitor of Notum | Pyridazine | Sulfur Compound | Triazol | Trifluoro
ARUK3004876Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole | Trifluoro
ARUK3006560Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole | Trifluoro
ARUK3006561Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole | Trifluoro
ARUK3006562Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole | Trifluoro
Bisuracil-pentylammonium-2hACHE Trifluoro | Uracil derivative
CHEMBL2058971DPP4N_Peptidase_S9 Pyrrolidine | Quinoline | Sulfur Compound | Thiazolidine | Trifluoro
CHEMBL2147710DPP4N_Peptidase_S9 Pyrazole | Pyrrolidine | Sulfur Compound | Thiazolidine | Trifluoro
CHEMBL2313198Epoxide_hydrolase Carboxamide | Piperidine | Sulfonamide | Sulfur Compound | Trifluoro
CHEMBL233360DPP4N_Peptidase_S9 Triazol | Trifluoro
CHEMBL238787ABHD6-Lip | Carb_B_Chordata | Hormone-sensitive_lipase_like Carbamate | Piperidine | Trifluoro
CHEMBL2392714Epoxide_hydrolase Carboxamide | Piperidine | Triazine | Trifluoro
CHEMBL3087809ACHE Sulfonamide | Sulfur Compound | Trifluoro
CHEMBL3087815ACHE Benzenesulfonamide | Sulfonamide | Sulfur Compound | Trifluoro
CHEMBL3402236-49P-4Y2SEpoxide_hydrolase Pyrazole | Trifluoro
CHEMBL3792924PAF-Acetylhydrolase Sulfur Compound | Thiomorpholine | Trifluoro
CHEMBL3793506PAF-Acetylhydrolase Cyanide | Morpholine | Pyrimidine | Trifluoro
CHEMBL4076292PAF-Acetylhydrolase Cyanide | Sulfur Compound | Trifluoro
CHEMBL442384-S0E-3WK8Epoxide_hydrolase Benzothiazol | Not A/B H target | Sulfur Compound | Trifluoro
CHEMBL4451596Epoxide_hydrolase Pyridine | Sulfonamide | Sulfur Compound | Trifluoro
CHEMBL45663-49N-4Y2QEpoxide_hydrolase Piperazine | Pyridine | Trifluoro
CID155803782ABHD17-depalmitoylase | LYsophospholipase_carboxylesterase Morpholine | Piperazine | Pyrazole | Sulfonamide | Sulfur Compound | Trifluoro
CID155803786ABHD17-depalmitoylase Morpholine | Piperazine | Pyrazole | Sulfonamide | Sulfur Compound | Trifluoro
CID155803792ABHD17-depalmitoylase | LYsophospholipase_carboxylesterase Morpholine | Piperazine | Pyrazole | Sulfonamide | Sulfur Compound | Trifluoro
Carboxamide-triflurophenyl-D5CDPP4N_Peptidase_S9 Carboxamide | Trifluoro
Coumarinyl-ethyl-p-trifluoroacetamidophenylmethylphosphonateBCHE Coumarin | Halo ketone | Organophosphate | Trifluoro
Cyclic-Hydrazine-DerivativeDPP4N_Peptidase_S9 Azepane | Diazepan | Trifluoro
D3CDPP4N_Peptidase_S9 Carboxamide | Pyrrolidine | Trifluoro
DA-12166DPP4N_Peptidase_S9 Gliptin | Trifluoro
DA-12228DPP4N_Peptidase_S9 Gliptin | Piperazine | Trifluoro
DETFPCarb_B_Chordata | Carboxylesterase | Juvenile_hormone_esterase Halo ketone | Sulfur Compound | Trifluoro
DLIDPP4N_Peptidase_S9 Pyrimidine | Pyrrolidine | Sulfur Compound | Trifluoro
DO34Lipase_3 Carbamate | Piperazine | Trifluoro | tert-Butyl | tert-Butyloxycarbonyl
DarapladibPAF-Acetylhydrolase Pyrimidine | Sulfur Compound | Trifluoro
Diazepan-AJHDPP4N_Peptidase_S9 Azepane | Diazepan | Trifluoro
Diazepanone-Analog-1DPP4N_Peptidase_S9 Azepane | Diazepan | Trifluoro
Diazepanone-Analog-18DPP4N_Peptidase_S9 Azepane | Diazepan | Trifluoro
EC5026Epoxide_hydrolase Piperidine | Trifluoro | Urea derivative
EvogliptinDPP4N_Peptidase_S9 Drug | Gliptin | Trifluoro
FBQACHE Derivative of Tacrine | Quinoline | Sulfur Compound | Transition state analogue | Trifluoro
FEPADMonoglyceridelipase_lysophospholip Azetidin | PET probe | Piperazine | Sulfur Compound | Thiazolidine | Trifluoro
Fluphenazine Not A/B H target | Phenothiazine | Sulfur Compound | Trifluoro
FulvestrantEpoxide_hydrolase Drug | Not A/B H target | Phenanthrene | Sulfur Compound | Trifluoro
GTPL9797PAF-Acetylhydrolase Benzenesulfonamide | Piperidine | Sulfonamide | Sulfur Compound | Trifluoro
GemigliptinDPP4N_Peptidase_S9 Drug | Gliptin | Piperidine | Pyrimidine | Trifluoro
HL2DPP4N_Peptidase_S9 Cyanide | Trifluoro
HT-01ABHD6-Lip | Lipase_3 BODIPY-derivative | Boron compound | Carboxamide | Fluorescent Probe | Triazol | Trifluoro
HexafluoracetoneHydroxynitrile_lyase Halo ketone | Trifluoro
JW651Monoglyceridelipase_lysophospholip | Plasmodium_subtelomeric_PST-A Carbamate | Halo ketone | Piperazine | Trifluoro
KK073RsbQ-like Triazol | Trifluoro | Urea derivative
KML29Monoglyceridelipase_lysophospholip | Plasmodium_subtelomeric_PST-A Benzodioxo | Carbamate | Halo ketone | Piperidine | Trifluoro
LK864Epoxide_hydrolase Azaspiro | Sulfonyl | Sulfur Compound | Trifluoro | Urea derivative
MBTFPCutinase | Juvenile_hormone_esterase Halo ketone | Sulfur Compound | Transition state analogue | Trifluoro
ML348LYsophospholipase_carboxylesterase Piperazine | Trifluoro
NAFACHE Quaternary compound | Transition state analogue | Trifluoro
NeogliptinDPP4N_Peptidase_S9 Azabicyclo | Cyanide | Gliptin | Trifluoro
Nitrophenyl-trifluoroethyl-arsenocholineACHE Trifluoro | pNP
OTFPCutinase | Juvenile_hormone_esterase Halo ketone | Sulfur Compound | Trifluoro
OTFPdOHSO2Juvenile_hormone_esterase Halo ketone | Sulfonyl | Sulfur Compound | Trifluoro
OWW-6YL4Epoxide_hydrolase 5-Lipoxygenase inhibitor | Multitarget | Trifluoro
PETFPCutinase Sulfur Compound | Trifluoro
PF-06795071Monoglyceridelipase_lysophospholip Azabicyclo | Carbamate | PET probe | Pyrazole | Trifluoro
PTUPBEpoxide_hydrolase Multitarget | Pyrazole | Sulfonamide | Sulfur Compound | Trifluoro | Urea derivative
Piperidine-constrained-phenethylamine-42DPP4N_Peptidase_S9 Piperidine | Pyrimidine | Sulfur Compound | Trifluoro
Piperidine-fused-benzimidazole-25DPP4N_Peptidase_S9 Benzimidazole | Imidazole | Piperidine | Sulfonyl | Sulfur Compound | Trifluoro
Piperidine-fused-benzimidazole-34DPP4N_Peptidase_S9 Benzimidazole | Piperidine | Trifluoro
Piperidinone-constrained-phenethylamine-31DPP4N_Peptidase_S9 Benzodioxo | Piperidine | Trifluoro
PrusogliptinDPP4N_Peptidase_S9 Cyanide | Gliptin | Pyrrolidine | Trifluoro
Pyrrole-26-6YSKPectinacetylesterase-Notum Pyrrole_Pyrrolidine-derivative | Trifluoro
Pyrrole-5-6YUYPectinacetylesterase-Notum Pyrrole_Pyrrolidine-derivative | Trifluoro
RegorafenibEpoxide_hydrolase Carboxamide | Not A/B H target | Trifluoro | Urea derivative | multi-kinase inhibitor
RilapladibPAF-Acetylhydrolase Piperidine | Sulfur Compound | Trifluoro
RiluzolePectinacetylesterase-Notum Benzothiazol | Drug | Fragment inhibitor of Notum | Not A/B H target | Sulfur Compound | Trifluoro
SCHEMBL15272467Epoxide_hydrolase Piperidine | Trifluoro | Urea derivative
SCHEMBL19305555DPP4N_Peptidase_S9 Trifluoro
SCHEMBL21776992Pectinacetylesterase-Notum Oxadiazol | Oxadiazolone | Trifluoro
SCHEMBL22462761Monoglyceridelipase_lysophospholip Azetidin | PET probe | Trifluoro | Urea derivative
SR-3420CGI-58_ABHD5_ABHD4 Benzothiazepin | Sulfur Compound | Trifluoro | Urea derivative
SZCEpoxide_hydrolase Benzimidazole | Imidazole | Sulfonamide | Sulfur Compound | Trifluoro
SitagliptinDPP4N_Peptidase_S9 Drug | Gliptin | Piperidine | Triazol | Trifluoro
SorafenibEpoxide_hydrolase Carboxamide | Not A/B H target | Trifluoro | Urea derivative | multi-kinase inhibitor
Sulfonamide-D1CDPP4N_Peptidase_S9 Benzenesulfonamide | Sulfonamide | Sulfur Compound | Trifluoro
TBTFAACHE | BCHE Halo ketone | Transition state analogue | Trifluoro | tert-Butyl
TK90Epoxide_hydrolase Butyrate | Carboxamide | Multitarget | PPARgamma ligand | Trifluoro
TMTFAACHE Halo ketone | Quaternary compound | Transition state analogue | Trifluoro | Trimethylammonium
TPPUEpoxide_hydrolase Piperidine | Trifluoro | Urea derivative
TPPU-6-Chlorotacrine-12cACHE | Epoxide_hydrolase Alkyl linked bis-ligand | Derivative of Tacrine | Multitarget | Piperidine | Trifluoro | Urea derivative
TPPU-methylEpoxide_hydrolase Piperidine | Trifluoro | Urea derivative
TUPSEpoxide_hydrolase Piperidine | Sulfonamide | Sulfur Compound | Trifluoro | Urea derivative
Tr-EH-urea-13Epoxide_hydrolase Trifluoro | Urea derivative
Triazol-triflurophenyl-DC3DPP4N_Peptidase_S9 Triazol | Trifluoro
Triazolopiperazine-based-beta-amino-acidDPP4N_Peptidase_S9 Piperidine | Triazol | Trifluoro
Trifluoperazine Not A/B H target | Phenothiazine | Sulfur Compound | Trifluoro
Trifluoro-6-dimethyl-2-heptanoneACHE | BCHE Halo ketone | Trifluoro
Triflupromazine Not A/B H target | Phenothiazine | Sulfur Compound | Trifluoro
XEN445Lipoprotein_Lipase Pyridine | Trifluoro
ZINC02141756Carb_B_Chordata Sulfur Compound | Trifluoro
ZINC11709541ACHE Derivative of Donepezil | Trifluoro
ZINC11996936ACHE Derivative of Donepezil | Trifluoro
ZifrosiloneACHE Halo ketone | Transition state analogue | Trifluoro
beta-aminoacyl-thiazolidine-2daDPP4N_Peptidase_S9 Sulfur Compound | Thiazolidine | Trifluoro

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer