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Author Report for: Castro NG

Contact information:

Castro Newton G
Departamento de Farmacologia Basica e Clinica, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, RJ
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    Title: Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer's Disease
    de Freitas Silva M, Tardelli Lima E, Pruccoli L, Castro NG, Guimares MJR, F MRdS, Fonseca Nadur N, de Azevedo LL, Kummerle AE and Viegas C <4 more author(s)>
    Ref: Molecules, 25:, 2020 : PubMed


    Title: Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates
    Dias Viegas FP, de Freitas Silva M, Divino da Rocha M, Castelli MR, Riquiel MM, Machado RP, Vaz SM, Simoes de Lima LM, Mancini KC and Viegas C, Jr. <24 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 147:48, 2018 : PubMed


    Title: Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease
    Dias KS, de Paula CT, Dos Santos T, Souza IN, Boni MS, Guimaraes MJ, da Silva FM, Castro NG, Neves GA and Viegas C, Jr. <11 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 130:440, 2017 : PubMed


    Title: Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease
    Lemes LF, de Andrade Ramos G, de Oliveira AS, da Silva FM, de Castro Couto G, da Silva Boni M, Guimaraes MJ, Souza IN, Bartolini M and Romeiro LA <9 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 108:687, 2015 : PubMed


    Title: Design, synthesis, and evaluation of guanylhydrazones as potential inhibitors or reactivators of acetylcholinesterase
    Petronilho EC, Renno MD, Castro NG, da Silva FM, Pinto AD, Figueroa-Villar JD
    Ref: J Enzyme Inhib Med Chem, :1, 2015 : PubMed


    Title: Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via CaM kinase II signaling
    Diniz LP, Tortelli V, Garcia MN, Araujo AP, Melo HM, Seixas da Silva GS, De Felice FG, Alves-Leon SV, de Souza JM and Gomes FC <2 more author(s)>
    Ref: Glia, 62:1917, 2014 : PubMed


    Title: LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation
    Tributino JL, Santos ML, Mesquita CM, Lima CK, Silva LL, Maia RC, Duarte CD, Barreiro EJ, Fraga CA and Guimaraes MZ <2 more author(s)>
    Ref: British Journal of Pharmacology, 159:1716, 2010 : PubMed


    Title: Geissospermum vellosii stembark: anticholinesterase activity and improvement of scopolamine-induced memory deficits
    Lima JA, Costa RS, Epifanio RA, Castro NG, Rocha MS, Pinto AC
    Ref: Pharmacol Biochem Behav, 92:508, 2009 : PubMed


    Title: New potential AChE inhibitor candidates
    de Paula AA, Martins JB, dos Santos ML, Nascente Lde C, Romeiro LA, Areas TF, Vieira KS, Gamboa NF, Castro NG, Gargano R
    Ref: Eur Journal of Medicinal Chemistry, 44:3754, 2009 : PubMed


    Title: CNS-selective noncompetitive cholinesterase inhibitors derived from the natural piperidine alkaloid (-)-spectaline
    Castro NG, Costa RS, Pimentel LS, Danuello A, Romeiro NC, Viegas C, Jr., Barreiro EJ, Fraga CA, Bolzani VS, Rocha MS
    Ref: European Journal of Pharmacology, 580:339, 2008 : PubMed


    Title: The magnitude of alpha7 nicotinic receptor currents in rat hippocampal neurons is dependent upon GABAergic activity and depolarization
    Santos HR, Ribeiro HS, Setti-Perdigao P, Albuquerque EX, Castro NG
    Ref: Journal of Pharmacology & Experimental Therapeutics, 319:376, 2006 : PubMed


    Title: Binding of [3H]MK-801 in subcellular fractions of Schistosoma mansoni: evidence for interaction with nicotinic receptors
    Pessoa RF, Castro NG, Noel F
    Ref: Biochemical Pharmacology, 69:1509, 2005 : PubMed


    Title: New selective acetylcholinesterase inhibitors designed from natural piperidine alkaloids
    Viegas C, Jr., Bolzani VS, Pimentel LS, Castro NG, Cabral RF, Costa RS, Floyd C, Rocha MS, Young MC and Fraga CA <1 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry, 13:4184, 2005 : PubMed


    Title: Spine density and dendritic branching pattern of hippocampal CA1 pyramidal neurons in neonatal rats chronically exposed to the organophosphate paraoxon
    Santos HR, Cintra WM, Aracava Y, Maciel CM, Castro NG, Albuquerque EX
    Ref: Neurotoxicology, 25:481, 2004 : PubMed


    Title: Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: a new class of potent and selective acetylcholinesterase inhibitors
    Barreiro EJ, Camara CA, Verli H, Brazil-Mas L, Castro NG, Cintra WM, Aracava Y, Rodrigues CR, Fraga CA
    Ref: Journal of Medicinal Chemistry, 46:1144, 2003 : PubMed


    Title: Low concentrations of pyridostigmine prevent soman-induced inhibition of GABAergic transmission in the central nervous system: involvement of muscarinic receptors
    Santos MD, Pereira EF, Aracava Y, Castro NG, Fawcett WP, Randall WR, Albuquerque EX
    Ref: Journal of Pharmacology & Experimental Therapeutics, 304:254, 2003 : PubMed


    Title: A novel thienylhydrazone, (2-thienylidene)3,4-methylenedioxybenzoylhydrazine, increases inotropism and decreases fatigue of skeletal muscle
    Gonzalez-Serratos H, Chang R, Pereira EF, Castro NG, Aracava Y, Melo PA, Lima PC, Fraga CA, Barreiro EJ, Albuquerque EX
    Ref: Journal of Pharmacology & Experimental Therapeutics, 299:558, 2001 : PubMed


    Title: Choline and acetylcholine have similar kinetic properties of activation and desensitization on the alpha7 nicotinic receptors in rat hippocampal neurons
    Mike A, Castro NG, Albuquerque EX
    Ref: Brain Research, 882:155, 2000 : PubMed


    Title: Properties of neuronal nicotinic acetylcholine receptors: pharmacological characterization and modulation of synaptic function
    Albuquerque EX, Alkondon M, Pereira EF, Castro NG, Schrattenholz A, Barbosa CT, Bonfante-Cabarcas R, Aracava Y, Eisenberg HM, Maelicke A
    Ref: Journal of Pharmacology & Experimental Therapeutics, 280:1117, 1997 : PubMed


    Title: Nicotinic receptor function in the mammalian central nervous system
    Albuquerque EX, Pereira EF, Castro NG, Alkondon M, Reinhardt S, Schroder H, Maelicke A
    Ref: Annals of the New York Academy of Sciences, 757:48, 1995 : PubMed


    Title: alpha-Bungarotoxin-sensitive hippocampal nicotinic receptor channel has a high calcium permeability
    Castro NG, Albuquerque EX
    Ref: Biophysical Journal, 68:516, 1995 : PubMed


    Title: Brief-lifetime, fast-inactivating ion channels account for the alpha-bungarotoxin-sensitive nicotinic response in hippocampal neurons
    Castro NG, Albuquerque EX
    Ref: Neuroscience Letters, 164:137, 1993 : PubMed


    Title: A novel agonist binding site on nicotinic acetylcholine receptors
    Pereira EF, Alkondon M, Tano T, Castro NG, Froes-Ferrao MM, Rozental R, Aronstam RS, Schrattenholz A, Maelicke A, Albuquerque EX
    Ref: J Recept Res, 13:413, 1993 : PubMed


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