Report for Conn PJ

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References (36)

Title : Ventral tegmental area M5 muscarinic receptors mediate effort-choice responding and nucleus accumbens dopamine in a sex-specific manner - Nunes_2023_J.Pharmacol.Exp.Ther__
Author(s) : Nunes EJ , Kebede N , Haight JL , Foster DJ , Lindsley C , Conn PJ , Addy N
Ref : Journal of Pharmacology & Experimental Therapeutics , : , 2023
Abstract : Nunes_2023_J.Pharmacol.Exp.Ther__
ESTHER : Nunes_2023_J.Pharmacol.Exp.Ther__
PubMedSearch : Nunes_2023_J.Pharmacol.Exp.Ther__
PubMedID: 36828630

Title : Modulation of arousal and sleep\/wake architecture by M(1) PAM VU0453595 across young and aged rodents and nonhuman primates - Gould_2020_Neuropsychopharmacology_45_2219
Author(s) : Gould RW , Russell JK , Nedelcovych MT , Bubser M , Blobaum AL , Bridges TM , Newhouse PA , Lindsley CW , Conn PJ , Nader MA , Jones CK
Ref : Neuropsychopharmacology , 45 :2219 , 2020
Abstract : Gould_2020_Neuropsychopharmacology_45_2219
ESTHER : Gould_2020_Neuropsychopharmacology_45_2219
PubMedSearch : Gould_2020_Neuropsychopharmacology_45_2219
PubMedID: 32868847

Title : Examining the role of muscarinic M5 receptors in VTA cholinergic modulation of depressive-like and anxiety-related behaviors in rats - Nunes_2020_Neuropharmacol__108089
Author(s) : Nunes EJ , Rupprecht LE , Foster DJ , Lindsley CW , Conn PJ , Addy NA
Ref : Neuropharmacology , :108089 , 2020
Abstract : Nunes_2020_Neuropharmacol__108089
ESTHER : Nunes_2020_Neuropharmacol__108089
PubMedSearch : Nunes_2020_Neuropharmacol__108089
PubMedID: 32268153

Title : M4 mAChR-Mediated Modulation of Glutamatergic Transmission at Corticostriatal Synapses - Pancani_2014_ACS.Chem.Neurosci_5_318
Author(s) : Pancani T , Bolarinwa C , Smith Y , Lindsley CW , Conn PJ , Xiang Z
Ref : ACS Chem Neurosci , 5 :318 , 2014
Abstract : Pancani_2014_ACS.Chem.Neurosci_5_318
ESTHER : Pancani_2014_ACS.Chem.Neurosci_5_318
PubMedSearch : Pancani_2014_ACS.Chem.Neurosci_5_318
PubMedID: 24528004

Title : Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2\/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence - Dhanya_2014_J.Med.Chem_57_4154
Author(s) : Dhanya RP , Sheffler DJ , Dahl R , Davis M , Lee PS , Yang L , Nickols HH , Cho HP , Smith LH , D'Souza MS , Conn PJ , Der-Avakian A , Markou A , Cosford ND
Ref : Journal of Medicinal Chemistry , 57 :4154 , 2014
Abstract : Dhanya_2014_J.Med.Chem_57_4154
ESTHER : Dhanya_2014_J.Med.Chem_57_4154
PubMedSearch : Dhanya_2014_J.Med.Chem_57_4154
PubMedID: 24735492

Title : Development of allosteric modulators of GPCRs for treatment of CNS disorders - Nickols_2014_Neurobiol.Dis_61_55
Author(s) : Nickols HH , Conn PJ
Ref : Neurobiol Dis , 61 :55 , 2014
Abstract : Nickols_2014_Neurobiol.Dis_61_55
ESTHER : Nickols_2014_Neurobiol.Dis_61_55
PubMedSearch : Nickols_2014_Neurobiol.Dis_61_55
PubMedID: 24076101

Title : Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models - Digby_2012_J.Neurosci_32_8532
Author(s) : Digby GJ , Noetzel MJ , Bubser M , Utley TJ , Walker AG , Byun NE , LeBois EP , Xiang Z , Sheffler DJ , Cho HP , Davis AA , Nemirovsky NE , Mennenga SE , Camp BW , Bimonte-Nelson HA , Bode J , Italiano K , Morrison R , Daniels JS , Niswender CM , Olive MF , Lindsley CW , Jones CK , Conn PJ
Ref : Journal of Neuroscience , 32 :8532 , 2012
Abstract : Digby_2012_J.Neurosci_32_8532
ESTHER : Digby_2012_J.Neurosci_32_8532
PubMedSearch : Digby_2012_J.Neurosci_32_8532
PubMedID: 22723693

Title : Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012 - Melancon_2012_Bioorg.Med.Chem.Lett_22_1044
Author(s) : Melancon BJ , Lamers AP , Bridges TM , Sulikowski GA , Utley TJ , Sheffler DJ , Noetzel MJ , Morrison RD , Daniels JS , Niswender CM , Jones CK , Conn PJ , Lindsley CW , Wood MR
Ref : Bioorganic & Medicinal Chemistry Lett , 22 :1044 , 2012
Abstract : Melancon_2012_Bioorg.Med.Chem.Lett_22_1044
ESTHER : Melancon_2012_Bioorg.Med.Chem.Lett_22_1044
PubMedSearch : Melancon_2012_Bioorg.Med.Chem.Lett_22_1044
PubMedID: 22197142

Title : Emerging approaches for treatment of schizophrenia: modulation of cholinergic signaling - Foster_2012_Discov.Med_14_413
Author(s) : Foster DJ , Jones CK , Conn PJ
Ref : Discov Med , 14 :413 , 2012
Abstract : Foster_2012_Discov.Med_14_413
ESTHER : Foster_2012_Discov.Med_14_413
PubMedSearch : Foster_2012_Discov.Med_14_413
PubMedID: 23272693

Title : Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor - Salovich_2012_Bioorg.Med.Chem.Lett_22_5084
Author(s) : Salovich JM , Vinson PN , Sheffler DJ , Lamsal A , Utley TJ , Blobaum AL , Bridges TM , Le U , Jones CK , Wood MR , Daniels JS , Conn PJ , Niswender CM , Lindsley CW , Hopkins CR
Ref : Bioorganic & Medicinal Chemistry Lett , 22 :5084 , 2012
Abstract : Salovich_2012_Bioorg.Med.Chem.Lett_22_5084
ESTHER : Salovich_2012_Bioorg.Med.Chem.Lett_22_5084
PubMedSearch : Salovich_2012_Bioorg.Med.Chem.Lett_22_5084
PubMedID: 22738637

Title : Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery -
Author(s) : Melancon BJ , Hopkins CR , Wood MR , Emmitte KA , Niswender CM , Christopoulos A , Conn PJ , Lindsley CW
Ref : Journal of Medicinal Chemistry , 55 :1445 , 2012
PubMedID: 22148748

Title : The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease - Jones_2012_J.Pharmacol.Exp.Ther_340_404
Author(s) : Jones CK , Bubser M , Thompson AD , Dickerson JW , Turle-Lorenzo N , Amalric M , Blobaum AL , Bridges TM , Morrison RD , Jadhav S , Engers DW , Italiano K , Bode J , Daniels JS , Lindsley CW , Hopkins CR , Conn PJ , Niswender CM
Ref : Journal of Pharmacology & Experimental Therapeutics , 340 :404 , 2012
Abstract : Jones_2012_J.Pharmacol.Exp.Ther_340_404
ESTHER : Jones_2012_J.Pharmacol.Exp.Ther_340_404
PubMedSearch : Jones_2012_J.Pharmacol.Exp.Ther_340_404
PubMedID: 22088953

Title : Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence - Sidique_2012_J.Med.Chem_55_9434
Author(s) : Sidique S , Dhanya RP , Sheffler DJ , Nickols HH , Yang L , Dahl R , Mangravita-Novo A , Smith LH , D'Souza MS , Semenova S , Conn PJ , Markou A , Cosford ND
Ref : Journal of Medicinal Chemistry , 55 :9434 , 2012
Abstract : Sidique_2012_J.Med.Chem_55_9434
ESTHER : Sidique_2012_J.Med.Chem_55_9434
PubMedSearch : Sidique_2012_J.Med.Chem_55_9434
PubMedID: 23009245

Title : Roles of the M1 muscarinic acetylcholine receptor subtype in the regulation of basal ganglia function and implications for the treatment of Parkinson's disease - Xiang_2012_J.Pharmacol.Exp.Ther_340_595
Author(s) : Xiang Z , Thompson AD , Jones CK , Lindsley CW , Conn PJ
Ref : Journal of Pharmacology & Experimental Therapeutics , 340 :595 , 2012
Abstract : Xiang_2012_J.Pharmacol.Exp.Ther_340_595
ESTHER : Xiang_2012_J.Pharmacol.Exp.Ther_340_595
PubMedSearch : Xiang_2012_J.Pharmacol.Exp.Ther_340_595
PubMedID: 22135383

Title : Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe - Reid_2011_Bioorg.Med.Chem.Lett_21_2697
Author(s) : Reid PR , Bridges TM , Sheffler DJ , Cho HP , Lewis LM , Days E , Daniels JS , Jones CK , Niswender CM , Weaver CD , Conn PJ , Lindsley CW , Wood MR
Ref : Bioorganic & Medicinal Chemistry Lett , 21 :2697 , 2011
Abstract : Reid_2011_Bioorg.Med.Chem.Lett_21_2697
ESTHER : Reid_2011_Bioorg.Med.Chem.Lett_21_2697
PubMedSearch : Reid_2011_Bioorg.Med.Chem.Lett_21_2697
PubMedID: 21194936

Title : Differential effects of allosteric M(1) muscarinic acetylcholine receptor agonists on receptor activation, arrestin 3 recruitment, and receptor downregulation - Davis_2010_ACS.Chem.Neurosci_1_542
Author(s) : Davis AA , Heilman CJ , Brady AE , Miller NR , Fuerstenau-Sharp M , Hanson BJ , Lindsley CW , Conn PJ , Lah JJ , Levey AI
Ref : ACS Chem Neurosci , 1 :542 , 2010
Abstract : Davis_2010_ACS.Chem.Neurosci_1_542
ESTHER : Davis_2010_ACS.Chem.Neurosci_1_542
PubMedSearch : Davis_2010_ACS.Chem.Neurosci_1_542
PubMedID: 20835371

Title : Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders - Digby_2010_Mol.Biosyst_6_1345
Author(s) : Digby GJ , Shirey JK , Conn PJ
Ref : Mol Biosyst , 6 :1345 , 2010
Abstract : Digby_2010_Mol.Biosyst_6_1345
ESTHER : Digby_2010_Mol.Biosyst_6_1345
PubMedSearch : Digby_2010_Mol.Biosyst_6_1345
PubMedID: 20582339

Title : Attenuation of cocaine's reinforcing and discriminative stimulus effects via muscarinic M1 acetylcholine receptor stimulation - Thomsen_2010_J.Pharmacol.Exp.Ther_332_959
Author(s) : Thomsen M , Conn PJ , Lindsley C , Wess J , Boon JY , Fulton BS , Fink-Jensen A , Caine SB
Ref : Journal of Pharmacology & Experimental Therapeutics , 332 :959 , 2010
Abstract : Thomsen_2010_J.Pharmacol.Exp.Ther_332_959
ESTHER : Thomsen_2010_J.Pharmacol.Exp.Ther_332_959
PubMedSearch : Thomsen_2010_J.Pharmacol.Exp.Ther_332_959
PubMedID: 19996296

Title : Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system - Lebois_2010_ACS.Chem.Neurosci_1_104
Author(s) : LeBois EP , Bridges TM , Lewis LM , Dawson ES , Kane AS , Xiang Z , Jadhav SB , Yin H , Kennedy JP , Meiler J , Niswender CM , Jones CK , Conn PJ , Weaver CD , Lindsley CW
Ref : ACS Chem Neurosci , 1 :104 , 2010
Abstract : Lebois_2010_ACS.Chem.Neurosci_1_104
ESTHER : Lebois_2010_ACS.Chem.Neurosci_1_104
PubMedSearch : Lebois_2010_ACS.Chem.Neurosci_1_104
PubMedID: 21961051

Title : The antipsychotic potential of muscarinic allosteric modulation - Bridges_2010_Drug.News.Perspect_23_229
Author(s) : Bridges TM , LeBois EP , Hopkins CR , Wood MR , Jones CK , Conn PJ , Lindsley CW
Ref : Drug News Perspect , 23 :229 , 2010
Abstract : Bridges_2010_Drug.News.Perspect_23_229
ESTHER : Bridges_2010_Drug.News.Perspect_23_229
PubMedSearch : Bridges_2010_Drug.News.Perspect_23_229
PubMedID: 20520852

Title : A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning - Shirey_2009_J.Neurosci_29_14271
Author(s) : Shirey JK , Brady AE , Jones PJ , Davis AA , Bridges TM , Kennedy JP , Jadhav SB , Menon UN , Xiang Z , Watson ML , Christian EP , Doherty JJ , Quirk MC , Snyder DH , Lah JJ , Levey AI , Nicolle MM , Lindsley CW , Conn PJ
Ref : Journal of Neuroscience , 29 :14271 , 2009
Abstract : Shirey_2009_J.Neurosci_29_14271
ESTHER : Shirey_2009_J.Neurosci_29_14271
PubMedSearch : Shirey_2009_J.Neurosci_29_14271
PubMedID: 19906975

Title : A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning - Sheffler_2009_Mol.Pharmacol_76_356
Author(s) : Sheffler DJ , Williams R , Bridges TM , Xiang Z , Kane AS , Byun NE , Jadhav S , Mock MM , Zheng F , Lewis LM , Jones CK , Niswender CM , Weaver CD , Lindsley CW , Conn PJ
Ref : Molecular Pharmacology , 76 :356 , 2009
Abstract : Sheffler_2009_Mol.Pharmacol_76_356
ESTHER : Sheffler_2009_Mol.Pharmacol_76_356
PubMedSearch : Sheffler_2009_Mol.Pharmacol_76_356
PubMedID: 19407080

Title : Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor -
Author(s) : Kennedy JP , Bridges TM , Gentry PR , Brogan JT , Kane AS , Jones CK , Brady AE , Shirey JK , Conn PJ , Lindsley CW
Ref : ChemMedChem , 4 :1600 , 2009
PubMedID: 19705385

Title : Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity - Marlo_2009_Mol.Pharmacol_75_577
Author(s) : Marlo JE , Niswender CM , Days EL , Bridges TM , Xiang Y , Rodriguez AL , Shirey JK , Brady AE , Nalywajko T , Luo Q , Austin CA , Williams MB , Kim K , Williams R , Orton D , Brown HA , Lindsley CW , Weaver CD , Conn PJ
Ref : Molecular Pharmacology , 75 :577 , 2009
Abstract : Marlo_2009_Mol.Pharmacol_75_577
ESTHER : Marlo_2009_Mol.Pharmacol_75_577
PubMedSearch : Marlo_2009_Mol.Pharmacol_75_577
PubMedID: 19047481

Title : Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins - Bridges_2009_J.Med.Chem_52_3445
Author(s) : Bridges TM , Marlo JE , Niswender CM , Jones CK , Jadhav SB , Gentry PR , Plumley HC , Weaver CD , Conn PJ , Lindsley CW
Ref : Journal of Medicinal Chemistry , 52 :3445 , 2009
Abstract : Bridges_2009_J.Med.Chem_52_3445
ESTHER : Bridges_2009_J.Med.Chem_52_3445
PubMedSearch : Bridges_2009_J.Med.Chem_52_3445
PubMedID: 19438238

Title : Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe - Weaver_2009_Curr.Top.Med.Chem_9_1217
Author(s) : Weaver CD , Sheffler DJ , Lewis LM , Bridges TM , Williams R , Nalywajko NT , Kennedy JP , Mulder MM , Jadhav S , Aldrich LA , Jones CK , Marlo JE , Niswender CM , Mock MM , Zheng F , Conn PJ , Lindsley CW
Ref : Curr Top Med Chem , 9 :1217 , 2009
Abstract : Weaver_2009_Curr.Top.Med.Chem_9_1217
ESTHER : Weaver_2009_Curr.Top.Med.Chem_9_1217
PubMedSearch : Weaver_2009_Curr.Top.Med.Chem_9_1217
PubMedID: 19807667

Title : Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders - Conn_2009_Trends.Pharmacol.Sci_30_148
Author(s) : Conn PJ , Jones CK , Lindsley CW
Ref : Trends in Pharmacological Sciences , 30 :148 , 2009
Abstract : Conn_2009_Trends.Pharmacol.Sci_30_148
ESTHER : Conn_2009_Trends.Pharmacol.Sci_30_148
PubMedSearch : Conn_2009_Trends.Pharmacol.Sci_30_148
PubMedID: 19201489

Title : An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission - Shirey_2008_Nat.Chem.Biol_4_42
Author(s) : Shirey JK , Xiang Z , Orton D , Brady AE , Johnson KA , Williams R , Ayala JE , Rodriguez AL , Wess J , Weaver D , Niswender CM , Conn PJ
Ref : Nat Chemical Biology , 4 :42 , 2008
Abstract : Shirey_2008_Nat.Chem.Biol_4_42
ESTHER : Shirey_2008_Nat.Chem.Biol_4_42
PubMedSearch : Shirey_2008_Nat.Chem.Biol_4_42
PubMedID: 18059262

Title : Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats - Jones_2008_J.Neurosci_28_10422
Author(s) : Jones CK , Brady AE , Davis AA , Xiang Z , Bubser M , Tantawy MN , Kane AS , Bridges TM , Kennedy JP , Bradley SR , Peterson TE , Ansari MS , Baldwin RM , Kessler RM , Deutch AY , Lah JJ , Levey AI , Lindsley CW , Conn PJ
Ref : Journal of Neuroscience , 28 :10422 , 2008
Abstract : Jones_2008_J.Neurosci_28_10422
ESTHER : Jones_2008_J.Neurosci_28_10422
PubMedSearch : Jones_2008_J.Neurosci_28_10422
PubMedID: 18842902

Title : Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats - Brady_2008_J.Pharmacol.Exp.Ther_327_941
Author(s) : Brady AE , Jones CK , Bridges TM , Kennedy JP , Thompson AD , Heiman JU , Breininger ML , Gentry PR , Yin H , Jadhav SB , Shirey JK , Conn PJ , Lindsley CW
Ref : Journal of Pharmacology & Experimental Therapeutics , 327 :941 , 2008
Abstract : Brady_2008_J.Pharmacol.Exp.Ther_327_941
ESTHER : Brady_2008_J.Pharmacol.Exp.Ther_327_941
PubMedSearch : Brady_2008_J.Pharmacol.Exp.Ther_327_941
PubMedID: 18772318

Title : Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties - Bridges_2008_Bioorg.Med.Chem.Lett_18_5439
Author(s) : Bridges TM , Brady AE , Kennedy JP , Daniels RN , Miller NR , Kim K , Breininger ML , Gentry PR , Brogan JT , Jones CK , Conn PJ , Lindsley CW
Ref : Bioorganic & Medicinal Chemistry Lett , 18 :5439 , 2008
Abstract : Bridges_2008_Bioorg.Med.Chem.Lett_18_5439
ESTHER : Bridges_2008_Bioorg.Med.Chem.Lett_18_5439
PubMedSearch : Bridges_2008_Bioorg.Med.Chem.Lett_18_5439
PubMedID: 18805692

Title : Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen - Miller_2008_Bioorg.Med.Chem.Lett_18_5443
Author(s) : Miller NR , Daniels RN , Bridges TM , Brady AE , Conn PJ , Lindsley CW
Ref : Bioorganic & Medicinal Chemistry Lett , 18 :5443 , 2008
Abstract : Miller_2008_Bioorg.Med.Chem.Lett_18_5443
ESTHER : Miller_2008_Bioorg.Med.Chem.Lett_18_5443
PubMedSearch : Miller_2008_Bioorg.Med.Chem.Lett_18_5443
PubMedID: 18829311

Title : Muscarinic-induced modulation of potassium conductances is unchanged in mouse hippocampal pyramidal cells that lack functional M1 receptors - Rouse_2000_Neurosci.Lett_278_61
Author(s) : Rouse ST , Hamilton SE , Potter LT , Nathanson NM , Conn PJ
Ref : Neuroscience Letters , 278 :61 , 2000
Abstract : Rouse_2000_Neurosci.Lett_278_61
ESTHER : Rouse_2000_Neurosci.Lett_278_61
PubMedSearch : Rouse_2000_Neurosci.Lett_278_61
PubMedID: 10643801

Title : Muscarinic receptor subtypes involved in hippocampal circuits - Rouse_1999_Life.Sci_64(6-7)_501
Author(s) : Rouse ST , Marino MJ , Potter LT , Conn PJ , Levey AI
Ref : Life Sciences , 64 :501 , 1999
Abstract : Rouse_1999_Life.Sci_64(6-7)_501
ESTHER : Rouse_1999_Life.Sci_64(6-7)_501
PubMedSearch : Rouse_1999_Life.Sci_64(6-7)_501
PubMedID: 10069516

Title : Poster: Muscarinic modulation of hippocampal function in m1 knockout mice -
Author(s) : Rouse ST , Hamilton SE , Potter LT , Nathanson NM , Conn PJ
Ref : Life Sciences , 64 :588 , 1999
PubMedID:

Title : Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells - Marino_1998_Proc.Natl.Acad.Sci.U.S.A_95_11465
Author(s) : Marino MJ , Rouse ST , Levey AI , Potter LT , Conn PJ
Ref : Proc Natl Acad Sci U S A , 95 :11465 , 1998
Abstract : Marino_1998_Proc.Natl.Acad.Sci.U.S.A_95_11465
ESTHER : Marino_1998_Proc.Natl.Acad.Sci.U.S.A_95_11465
PubMedSearch : Marino_1998_Proc.Natl.Acad.Sci.U.S.A_95_11465
PubMedID: 9736760