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| Title : Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP\/PS1 Mice - Viayna_2021_J.Med.Chem_64_812 |
| Author(s) : Viayna E , Coquelle N , Cieslikiewicz-Bouet M , Cisternas P , Oliva CA , Sanchez-Lopez E , Ettcheto M , Bartolini M , De Simone A , Ricchini M , Rendina M , Pons M , Firuzi O , Perez B , Saso L , Andrisano V , Nachon F , Brazzolotto X , Garcia ML , Camins A , Silman I , Jean L , Inestrosa NC , Colletier JP , Renard PY , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 64 :812 , 2021 |
| Abstract : Viayna_2021_J.Med.Chem_64_812 |
| ESTHER : Viayna_2021_J.Med.Chem_64_812 |
| PubMedSearch : Viayna_2021_J.Med.Chem_64_812 |
| PubMedID: 33356266 |
| Gene_locus related to this paper: human-ACHE |
| Title : Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes - Pajk_2020_J.Enzyme.Inhib.Med.Chem_35_498 |
| Author(s) : Pajk S , Knez D , Kosak U , Zorovic M , Brazzolotto X , Coquelle N , Nachon F , Colletier JP , Zivin M , Stojan J , Gobec S |
| Ref : J Enzyme Inhib Med Chem , 35 :498 , 2020 |
| Abstract : Pajk_2020_J.Enzyme.Inhib.Med.Chem_35_498 |
| ESTHER : Pajk_2020_J.Enzyme.Inhib.Med.Chem_35_498 |
| PubMedSearch : Pajk_2020_J.Enzyme.Inhib.Med.Chem_35_498 |
| PubMedID: 31914836 |
| Gene_locus related to this paper: human-BCHE |
| Title : Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 - Oukoloff_2019_Eur.J.Med.Chem_168_58 |
| Author(s) : Oukoloff K , Coquelle N , Bartolini M , Naldi M , Le Guevel R , Bach S , Josselin B , Ruchaud S , Catto M , Pisani L , Denora N , Iacobazzi RM , Silman I , Sussman JL , Buron F , Colletier JP , Jean L , Routier S , Renard PY |
| Ref : Eur Journal of Medicinal Chemistry , 168 :58 , 2019 |
| Abstract : Oukoloff_2019_Eur.J.Med.Chem_168_58 |
| ESTHER : Oukoloff_2019_Eur.J.Med.Chem_168_58 |
| PubMedSearch : Oukoloff_2019_Eur.J.Med.Chem_168_58 |
| PubMedID: 30798053 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities - Knez_2018_Eur.J.Med.Chem_156_598 |
| Author(s) : Knez D , Coquelle N , Pislar A , Zakelj S , Jukic M , Sova M , Mravljak J , Nachon F , Brazzolotto X , Kos J , Colletier JP , Gobec S |
| Ref : Eur Journal of Medicinal Chemistry , 156 :598 , 2018 |
| Abstract : Knez_2018_Eur.J.Med.Chem_156_598 |
| ESTHER : Knez_2018_Eur.J.Med.Chem_156_598 |
| PubMedSearch : Knez_2018_Eur.J.Med.Chem_156_598 |
| PubMedID: 30031971 |
| Gene_locus related to this paper: human-BCHE |
| Title : The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity - Kosak_2018_J.Med.Chem_61_119 |
| Author(s) : Kosak U , Brus B , Knez D , Zakelj S , Trontelj J , Pislar A , Sink R , Jukic M , Zivin M , Podkowa A , Nachon F , Brazzolotto X , Stojan J , Kos J , Coquelle N , Salat K , Colletier JP , Gobec S |
| Ref : Journal of Medicinal Chemistry , 61 :119 , 2018 |
| Abstract : Kosak_2018_J.Med.Chem_61_119 |
| ESTHER : Kosak_2018_J.Med.Chem_61_119 |
| PubMedSearch : Kosak_2018_J.Med.Chem_61_119 |
| PubMedID: 29227101 |
| Gene_locus related to this paper: human-BCHE |
| Title : Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis - Galdeano_2018_Molecules_23_ |
| Author(s) : Galdeano C , Coquelle N , Cieslikiewicz-Bouet M , Bartolini M , Perez B , Clos MV , Silman I , Jean L , Colletier JP , Renard PY , Munoz-Torrero D |
| Ref : Molecules , 23 : , 2018 |
| Abstract : Galdeano_2018_Molecules_23_ |
| ESTHER : Galdeano_2018_Molecules_23_ |
| PubMedSearch : Galdeano_2018_Molecules_23_ |
| PubMedID: 29534488 |
| Gene_locus related to this paper: torca-ACHE |
| Title : N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents - Kosak_2017_Bioorg.Med.Chem_25_633 |
| Author(s) : Kosak U , Knez D , Coquelle N , Brus B , Pislar A , Nachon F , Brazzolotto X , Kos J , Colletier JP , Gobec S |
| Ref : Bioorganic & Medicinal Chemistry , 25 :633 , 2017 |
| Abstract : Kosak_2017_Bioorg.Med.Chem_25_633 |
| ESTHER : Kosak_2017_Bioorg.Med.Chem_25_633 |
| PubMedSearch : Kosak_2017_Bioorg.Med.Chem_25_633 |
| PubMedID: 27908752 |
| Gene_locus related to this paper: human-BCHE |
| Title : Development of an in-vivo active reversible butyrylcholinesterase inhibitor - Kosak_2016_Sci.Rep_6_39495 |
| Author(s) : Kosak U , Brus B , Knez D , Sink R , Zakelj S , Trontelj J , Pislar A , Slenc J , Gobec M , Zivin M , Tratnjek L , Perse M , Salat K , Podkowa A , Filipek B , Nachon F , Brazzolotto X , Wieckowska A , Malawska B , Stojan J , Rascan IM , Kos J , Coquelle N , Colletier JP , Gobec S |
| Ref : Sci Rep , 6 :39495 , 2016 |
| Abstract : Kosak_2016_Sci.Rep_6_39495 |
| ESTHER : Kosak_2016_Sci.Rep_6_39495 |
| PubMedSearch : Kosak_2016_Sci.Rep_6_39495 |
| PubMedID: 28000737 |
| Gene_locus related to this paper: human-BCHE |
| Title : Serial Femtosecond Crystallography and Ultrafast Absorption Spectroscopy of the Photoswitchable Fluorescent Protein IrisFP - Colletier_2016_J.Phys.Chem.Lett_7_882 |
| Author(s) : Colletier JP , Sliwa M , Gallat FX , Sugahara M , Guillon V , Schiro G , Coquelle N , Woodhouse J , Roux L , Gotthard G , Royant A , Uriarte LM , Ruckebusch C , Joti Y , Byrdin M , Mizohata E , Nango E , Tanaka T , Tono K , Yabashi M , Adam V , Cammarata M , Schlichting I , Bourgeois D , Weik M |
| Ref : J Phys Chem Lett , 7 :882 , 2016 |
| Abstract : Colletier_2016_J.Phys.Chem.Lett_7_882 |
| ESTHER : Colletier_2016_J.Phys.Chem.Lett_7_882 |
| PubMedSearch : Colletier_2016_J.Phys.Chem.Lett_7_882 |
| PubMedID: 26866390 |
| Title : Poster: Multi-target directed ligands: Electrophysiological characterization of an anticholinesterase inhibitor coupled to an agonist of alpha7 nicotinic acetylcholine receptor - |
| Author(s) : Araoz R , Bouet m , Bartolini M , Coquelle N , Colletier JP , Servent D , Molgo J , Jean L , Renard PY |
| Ref : Biochemical Pharmacology , 97 :621 , 2015 |
| PubMedID: |
| Title : Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents - Knez_2015_Bioorg.Med.Chem_23_4442 |
| Author(s) : Knez D , Brus B , Coquelle N , Sosic I , Sink R , Brazzolotto X , Mravljak J , Colletier JP , Gobec S |
| Ref : Bioorganic & Medicinal Chemistry , 23 :4442 , 2015 |
| Abstract : Knez_2015_Bioorg.Med.Chem_23_4442 |
| ESTHER : Knez_2015_Bioorg.Med.Chem_23_4442 |
| PubMedSearch : Knez_2015_Bioorg.Med.Chem_23_4442 |
| PubMedID: 26116179 |
| Gene_locus related to this paper: human-BCHE |
| Title : Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor - Brus_2014_J.Med.Chem_57_8167 |
| Author(s) : Brus B , Kosak U , Turk S , Pislar A , Coquelle N , Kos J , Stojan J , Colletier JP , Gobec S |
| Ref : Journal of Medicinal Chemistry , 57 :8167 , 2014 |
| Abstract : Brus_2014_J.Med.Chem_57_8167 |
| ESTHER : Brus_2014_J.Med.Chem_57_8167 |
| PubMedSearch : Brus_2014_J.Med.Chem_57_8167 |
| PubMedID: 25226236 |
| Gene_locus related to this paper: human-BCHE |