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| Title : Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning - Stewart_2004_J.Med.Chem_47_2348 |
| Author(s) : Stewart AO , Cowart MD , Moreland RB , Latshaw SP , Matulenko MA , Bhatia PA , Wang X , Daanen JF , Nelson SL , Terranova MA , Namovic MT , Donnelly-Roberts D , Miller LN , Nakane M , Sullivan JP , Brioni JD |
| Ref : Journal of Medicinal Chemistry , 47 :2348 , 2004 |
| Abstract : Stewart_2004_J.Med.Chem_47_2348 |
| ESTHER : Stewart_2004_J.Med.Chem_47_2348 |
| PubMedSearch : Stewart_2004_J.Med.Chem_47_2348 |
| PubMedID: 15084133 |
| Title : Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction - Cowart_2004_J.Med.Chem_47_3853 |
| Author(s) : Cowart M , Latshaw SP , Bhatia P , Daanen JF , Rohde J , Nelson SL , Patel M , Kolasa T , Nakane M , Uchic ME , Miller LN , Terranova MA , Chang R , Donnelly-Roberts D , Namovic MT , Hollingsworth PR , Martino BR , Lynch JJ, 3rd , Sullivan JP , Hsieh GC , Moreland RB , Brioni JD , Stewart AO |
| Ref : Journal of Medicinal Chemistry , 47 :3853 , 2004 |
| Abstract : Cowart_2004_J.Med.Chem_47_3853 |
| ESTHER : Cowart_2004_J.Med.Chem_47_3853 |
| PubMedSearch : Cowart_2004_J.Med.Chem_47_3853 |
| PubMedID: 15239663 |
| Title : Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice - Holladay_1998_Bioorg.Med.Chem.Lett_8_2797 |
| Author(s) : Holladay MW , Bai H , Li Y , Lin NH , Daanen JF , Ryther KB , Wasicak JT , Kincaid JF , He Y , Hettinger AM , Huang P , Anderson DJ , Bannon AW , Buckley MJ , Campbell JE , Donnelly-Roberts D , Gunther KL , Kim DJ , Kuntzweiler TA , Sullivan JP , Decker MW , Arneric SP |
| Ref : Bioorganic & Medicinal Chemistry Lett , 8 :2797 , 1998 |
| Abstract : Holladay_1998_Bioorg.Med.Chem.Lett_8_2797 |
| ESTHER : Holladay_1998_Bioorg.Med.Chem.Lett_8_2797 |
| PubMedSearch : Holladay_1998_Bioorg.Med.Chem.Lett_8_2797 |
| PubMedID: 9873625 |
| Title : ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys - Decker_1997_J.Pharmacol.Exp.Ther_283_247 |
| Author(s) : Decker MW , Bannon AW , Curzon P , Gunther KL , Brioni JD , Holladay MW , Lin NH , Li Y , Daanen JF , Buccafusco JJ , Prendergast MA , Jackson WJ , Arneric SP |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 283 :247 , 1997 |
| Abstract : Decker_1997_J.Pharmacol.Exp.Ther_283_247 |
| ESTHER : Decker_1997_J.Pharmacol.Exp.Ther_283_247 |
| PubMedSearch : Decker_1997_J.Pharmacol.Exp.Ther_283_247 |
| PubMedID: 9336330 |