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Author Report for: Danks MK

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    Title: Stem and progenitor cell-mediated tumor selective gene therapy
    Aboody KS, Najbauer J, Danks MK
    Ref: Gene Therapy, 15:739, 2008 : PubMed

            

    Title: An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11
    Wierdl M, Tsurkan L, Hyatt JL, Edwards CC, Hatfield MJ, Morton CL, Houghton PJ, Danks MK, Redinbo MR, Potter PM
    Ref: Cancer Gene Therapy, 15:183, 2008 : PubMed

            

    Title: Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma
    Danks MK, Yoon KJ, Bush RA, Remack JS, Wierdl M, Tsurkan L, Kim SU, Garcia E, Metz MZ and Aboody KS <2 more author(s)>
    Ref: Cancer Research, 67:22, 2007 : PubMed

            

    Title: Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1
    Hyatt JL, Wadkins RM, Tsurkan L, Hicks LD, Hatfield MJ, Edwards CC, Ross CR, 2nd, Cantalupo SA, Crundwell G and Potter PM <2 more author(s)>
    Ref: Journal of Medicinal Chemistry, 50:5727, 2007 : PubMed

            

    Title: Selective inhibition of carboxylesterases by isatins, indole-2,3-diones
    Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM
    Ref: Journal of Medicinal Chemistry, 50:1876, 2007 : PubMed

            

    Title: Development of a tumor-selective approach to treat metastatic cancer
    Aboody KS, Bush RA, Garcia E, Metz MZ, Najbauer J, Justus KA, Phelps DA, Remack JS, Yoon KJ and Danks MK <4 more author(s)>
    Ref: PLoS ONE, 1:e23, 2006 : PubMed

            

    Title: Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity
    Hyatt JL, Tsurkan L, Wierdl M, Edwards CC, Danks MK, Potter PM
    Ref: Mol Cancer Ther, 5:2281, 2006 : PubMed

            

    Title: Development of an etoposide prodrug for dual prodrug-enzyme antitumor therapy
    Yoon KJ, Qi J, Remack JS, Virga KG, Hatfield MJ, Potter PM, Lee RE, Danks MK
    Ref: Mol Cancer Ther, 5:1577, 2006 : PubMed

            

    Title: Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety
    Hyatt JL, Stacy V, Wadkins RM, Yoon KJ, Wierdl M, Edwards CC, Zeller M, Hunter AD, Danks MK and Potter PM <1 more author(s)>
    Ref: Journal of Medicinal Chemistry, 48:5543, 2005 : PubMed

            

    Title: Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice
    Morton CL, Iacono L, Hyatt JL, Taylor KR, Cheshire PJ, Houghton PJ, Danks MK, Stewart CF, Potter PM
    Ref: Cancer Chemother Pharmacol, 56:629, 2005 : PubMed

            

    Title: Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan
    Tyminski E, Leroy S, Terada K, Finkelstein DM, Hyatt JL, Danks MK, Potter PM, Saeki Y, Chiocca EA
    Ref: Cancer Research, 65:6850, 2005 : PubMed

            

    Title: Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases
    Wadkins RM, Hyatt JL, Wei X, Yoon KJ, Wierdl M, Edwards CC, Morton CL, Obenauer JC, Damodaran K and Potter PM <2 more author(s)>
    Ref: Journal of Medicinal Chemistry, 48:2906, 2005 : PubMed

            

    Title: Development of prodrugs for enzyme-mediated, tumor-selective therapy
    Yoon KJ, Potter PM, Danks MK
    Ref: Curr Med Chem Anticancer Agents, 5:107, 2005 : PubMed

            

    Title: Enzyme-prodrug systems: carboxylesterase/CPT-11
    Danks MK, Potter PM
    Ref: Methods Mol Med, 90:247, 2004 : PubMed

            

    Title: Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity
    Wadkins RM, Hyatt JL, Yoon KJ, Morton CL, Lee RE, Damodaran K, Beroza P, Danks MK, Potter PM
    Ref: Molecular Pharmacology, 65:1336, 2004 : PubMed

            

    Title: Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application
    Yoon KJ, Hyatt JL, Morton CL, Lee RE, Potter PM, Danks MK
    Ref: Mol Cancer Ther, 3:903, 2004 : PubMed

            

    Title: Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition
    Bencharit S, Morton CL, Hyatt JL, Kuhn P, Danks MK, Potter PM, Redinbo MR
    Ref: Chemical Biology, 10:341, 2003 : PubMed

            

    Title: A prodrug strategy using ONYX-015-based replicating adenoviruses to deliver rabbit carboxylesterase to tumor cells for conversion of CPT-11 to SN-38
    Stubdal H, Perin N, Lemmon M, Holman P, Bauzon M, Potter PM, Danks MK, Fattaey A, Dubensky T, Johnson L
    Ref: Cancer Research, 63:6900, 2003 : PubMed

            

    Title: p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11)
    Wierdl M, Morton CL, Harris LC, Danks MK, Schuetz JD, Potter PM
    Ref: Journal of Pharmacology & Experimental Therapeutics, 304:699, 2003 : PubMed

            

    Title: Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance
    Wierdl M, Wall A, Morton CL, Sampath J, Danks MK, Schuetz JD, Potter PM
    Ref: Molecular Pharmacology, 64:279, 2003 : PubMed

            

    Title: Activation of a camptothecin prodrug by specific carboxylesterases as predicted by quantitative structure-activity relationship and molecular docking studies
    Yoon KJ, Krull EJ, Morton CL, Bornmann WG, Lee RE, Potter PM, Danks MK
    Ref: Mol Cancer Ther, 2:1171, 2003 : PubMed

            

    Title: Synthesis and evaluation of esters and carbamates to identify critical functional groups for esterase-specific metabolism
    Yoon KJ, Morton CL, Potter PM, Danks MK, Lee RE
    Ref: Bioorganic & Medicinal Chemistry, 11:3237, 2003 : PubMed

            

    Title: Structural insights into CPT-11 activation by mammalian carboxylesterases
    Bencharit S, Morton CL, Howard-Williams EL, Danks MK, Potter PM, Redinbo MR
    Ref: Nat Struct Biol, 9:337, 2002 : PubMed

            

    Title: Efficacy and toxicity of a virus-directed enzyme prodrug therapy purging method: preclinical assessment and application to bone marrow samples from neuroblastoma patients
    Wagner LM, Guichard SM, Burger RA, Morton CL, Straign CM, Ashmun RA, Harris LC, Houghton PJ, Potter PM, Danks MK
    Ref: Cancer Research, 62:5001, 2002 : PubMed

            

    Title: Use of a modified ornithine decarboxylase promoter to achieve efficient c-MYC- or N-MYC-regulated protein expression
    Iyengar RV, Pawlik CA, Krull EJ, Phelps DA, Burger RA, Harris LC, Potter PM, Danks MK
    Ref: Cancer Research, 61:3045, 2001 : PubMed

            

    Title: A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11
    Meck MM, Wierdl M, Wagner LM, Burger RA, Guichard SM, Krull EJ, Harris LC, Potter PM, Danks MK
    Ref: Cancer Research, 61:5083, 2001 : PubMed

            

    Title: Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases
    Wadkins RM, Morton CL, Weeks JK, Oliver L, Wierdl M, Danks MK, Potter PM
    Ref: Molecular Pharmacology, 60:355, 2001 : PubMed

            

    Title: Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase
    Wierdl M, Morton CL, Weeks JK, Danks MK, Harris LC, Potter PM
    Ref: Cancer Research, 61:5078, 2001 : PubMed

            

    Title: Proficient metabolism of irinotecan by a human intestinal carboxylesterase
    Khanna R, Morton CL, Danks MK, Potter PM
    Ref: Cancer Research, 60:4725, 2000 : PubMed

            

    Title: Activation of CPT-11 in mice: identification and analysis of a highly effective plasma esterase
    Morton CL, Wierdl M, Oliver L, Ma MK, Danks MK, Stewart CF, Eiseman JL, Potter PM
    Ref: Cancer Research, 60:4206, 2000 : PubMed

            

    Title: Use of the ornithine decarboxylase promoter to achieve N-MYC-mediated overexpression of a rabbit carboxylesterase to sensitize neuroblastoma cells to CPT-11
    Pawlik CA, Iyengar RV, Krull EJ, Mason SE, Khanna R, Harris LC, Potter PM, Danks MK, Guichard SM
    Ref: Mol Ther, 1:457, 2000 : PubMed

            

    Title: Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation
    Wierdl M, Morton CL, Danks MK, Potter PM
    Ref: Biochemical Pharmacology, 59:773, 2000 : PubMed

            

    Title: Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy
    Danks MK, Morton CL, Krull EJ, Cheshire PJ, Richmond LB, Naeve CW, Pawlik CA, Houghton PJ, Potter PM
    Ref: Clin Cancer Research, 5:917, 1999 : PubMed

            

    Title: The anticancer prodrug CPT-11 is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to SN-38 by butyrylcholinesterase
    Morton CL, Wadkins RM, Danks MK, Potter PM
    Ref: Cancer Research, 59:1458, 1999 : PubMed

            

    Title: Overexpression of a rabbit liver carboxylesterase sensitizes human tumor cells to CPT-11
    Danks MK, Morton CL, Pawlik CA, Potter PM
    Ref: Cancer Research, 58:20, 1998 : PubMed

            

    Title: Conversion of the CPT-11 metabolite APC to SN-38 by rabbit liver carboxylesterase
    Guichard SM, Morton CL, Krull EJ, Stewart CF, Danks MK, Potter PM
    Ref: Clin Cancer Research, 4:3089, 1998 : PubMed

            

    Title: Cellular localization domains of a rabbit and a human carboxylesterase: influence on irinotecan (CPT-11) metabolism by the rabbit enzyme
    Potter PM, Wolverton JS, Morton CL, Wierdl M, Danks MK
    Ref: Cancer Research, 58:3627, 1998 : PubMed

            

    Title: Isolation and partial characterization of a cDNA encoding a rabbit liver carboxylesterase that activates the prodrug irinotecan (CPT-11)
    Potter PM, Pawlik CA, Morton CL, Naeve CW, Danks MK
    Ref: Cancer Research, 58:2646, 1998 : PubMed

            

    Title: In situ subcellular localization of epitope-tagged human and rabbit carboxylesterases
    Potter PM, Wolverton JS, Morton CL, Whipple DO, Danks MK
    Ref: Cytometry, 32:223, 1998 : PubMed

            


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