Full name : Ekstrom Fredrik
First name : Fredrik
Mail : CBRN Defence and Security\; Swedish Defence Research Agency\; 90182 Umea
Zip Code :
City :
Country : Sweden
Email : fredrik.ekstrom@foi.se
Phone : +4690106815
Fax :
Website : \/\/www.researchgate.net\/profile\/Fredrik_Ekstroem
Directory :
| Title : Structure-Activity Relationships Reveal Beneficial Selectivity Profiles of Inhibitors Targeting Acetylcholinesterase of Disease-Transmitting Mosquitoes - Vidal-Albalat_2023_J.Med.Chem__ |
| Author(s) : Vidal-Albalat A , Kindahl T , Rajeshwari R , Lindgren C , Forsgren N , Kitur S , Tengo LS , Ekstrom F , Kamau L , Linusson A |
| Ref : Journal of Medicinal Chemistry , : , 2023 |
| Abstract : Vidal-Albalat_2023_J.Med.Chem__ |
| ESTHER : Vidal-Albalat_2023_J.Med.Chem__ |
| PubMedSearch : Vidal-Albalat_2023_J.Med.Chem__ |
| PubMedID: 37094110 |
| Title : Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures - Ekstrom_2022_ACS.Med.Chem.Lett_13_499 |
| Author(s) : Ekstrom F , Gottinger A , Forsgren N , Catto M , Iacovino LG , Pisani P , Binda C |
| Ref : ACS Med Chem Lett , 13 :499 , 2022 |
| Abstract : Ekstrom_2022_ACS.Med.Chem.Lett_13_499 |
| ESTHER : Ekstrom_2022_ACS.Med.Chem.Lett_13_499 |
| PubMedSearch : Ekstrom_2022_ACS.Med.Chem.Lett_13_499 |
| PubMedID: 35300078 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Physical Mechanisms Governing Substituent Effects on Arene-Arene Interactions in a Protein Milieu - Andersson_2020_J.Phys.Chem.B_124_6529 |
| Author(s) : Andersson CD , Mishra BK , Forsgren N , Ekstrom F , Linusson A |
| Ref : J Phys Chem B , 124 :6529 , 2020 |
| Abstract : Andersson_2020_J.Phys.Chem.B_124_6529 |
| ESTHER : Andersson_2020_J.Phys.Chem.B_124_6529 |
| PubMedSearch : Andersson_2020_J.Phys.Chem.B_124_6529 |
| PubMedID: 32610016 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Noncovalent Inhibitors of Mosquito Acetylcholinesterase 1 with Resistance-Breaking Potency - Knutsson_2018_J.Med.Chem_61_10545 |
| Author(s) : Knutsson S , Engdahl C , Kumari R , Forsgren N , Lindgren C , Kindahl T , Kitur S , Wachira L , Kamau L , Ekstrom F , Linusson A |
| Ref : Journal of Medicinal Chemistry , 61 :10545 , 2018 |
| Abstract : Knutsson_2018_J.Med.Chem_61_10545 |
| ESTHER : Knutsson_2018_J.Med.Chem_61_10545 |
| PubMedSearch : Knutsson_2018_J.Med.Chem_61_10545 |
| PubMedID: 30339371 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Influence of Enantiomeric Inhibitors on the Dynamics of Acetylcholinesterase Measured by Elastic Incoherent Neutron Scattering - Andersson_2018_J.Phys.Chem.B_122_8516 |
| Author(s) : Andersson CD , Martinez N , Zeller D , Allgardsson A , Koza MM , Frick B , Ekstrom F , Peters J , Linusson A |
| Ref : J Phys Chem B , 122 :8516 , 2018 |
| Abstract : Andersson_2018_J.Phys.Chem.B_122_8516 |
| ESTHER : Andersson_2018_J.Phys.Chem.B_122_8516 |
| PubMedSearch : Andersson_2018_J.Phys.Chem.B_122_8516 |
| PubMedID: 30110543 |
| Title : N-Aryl-N'-ethyleneaminothioureas effectively inhibit acetylcholinesterase 1 from disease-transmitting mosquitoes - Knutsson_2017_Eur.J.Med.Chem_134_415 |
| Author(s) : Knutsson S , Kindahl T , Engdahl C , Nikjoo D , Forsgren N , Kitur S , Ekstrom F , Kamau L , Linusson A |
| Ref : Eur Journal of Medicinal Chemistry , 134 :415 , 2017 |
| Abstract : Knutsson_2017_Eur.J.Med.Chem_134_415 |
| ESTHER : Knutsson_2017_Eur.J.Med.Chem_134_415 |
| PubMedSearch : Knutsson_2017_Eur.J.Med.Chem_134_415 |
| PubMedID: 28433681 |
| Gene_locus related to this paper: anoga-ACHE1 |
| Title : An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet - Allgardsson_2017_Molecules_22_ |
| Author(s) : Allgardsson A , David Andersson C , Akfur C , Worek F , Linusson A , Ekstrom F |
| Ref : Molecules , 22 : , 2017 |
| Abstract : Allgardsson_2017_Molecules_22_ |
| ESTHER : Allgardsson_2017_Molecules_22_ |
| PubMedSearch : Allgardsson_2017_Molecules_22_ |
| PubMedID: 28867801 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6 - Allgardsson_2016_Proc.Natl.Acad.Sci.U.S.A_113_5514 |
| Author(s) : Allgardsson A , Berg L , Akfur C , Hornberg A , Worek F , Linusson A , Ekstrom F |
| Ref : Proc Natl Acad Sci U S A , 113 :5514 , 2016 |
| Abstract : Allgardsson_2016_Proc.Natl.Acad.Sci.U.S.A_113_5514 |
| ESTHER : Allgardsson_2016_Proc.Natl.Acad.Sci.U.S.A_113_5514 |
| PubMedSearch : Allgardsson_2016_Proc.Natl.Acad.Sci.U.S.A_113_5514 |
| PubMedID: 27140636 |
| Gene_locus related to this paper: human-ACHE |
| Title : Discovery of Selective Inhibitors Targeting Acetylcholinesterase 1 from Disease-Transmitting Mosquitoes - Engdahl_2016_J.Med.Chem_59_9409 |
| Author(s) : Engdahl C , Knutsson S , Ekstrom F , Linusson A |
| Ref : Journal of Medicinal Chemistry , 59 :9409 , 2016 |
| Abstract : Engdahl_2016_J.Med.Chem_59_9409 |
| ESTHER : Engdahl_2016_J.Med.Chem_59_9409 |
| PubMedSearch : Engdahl_2016_J.Med.Chem_59_9409 |
| PubMedID: 27598521 |
| Gene_locus related to this paper: anoga-ACHE1 , mouse-ACHE |
| Title : The Nature of Activated Non-classical Hydrogen Bonds: A Case Study on Acetylcholinesterase-Ligand Complexes - Berg_2016_Chemistry_22_2672 |
| Author(s) : Berg L , Mishra BK , Andersson CD , Ekstrom F , Linusson A |
| Ref : Chemistry , 22 :2672 , 2016 |
| Abstract : Berg_2016_Chemistry_22_2672 |
| ESTHER : Berg_2016_Chemistry_22_2672 |
| PubMedSearch : Berg_2016_Chemistry_22_2672 |
| PubMedID: 26751405 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Benefits of statistical molecular design, covariance analysis, and reference models in QSAR: a case study on acetylcholinesterase - Andersson_2015_J.Comput.Aided.Mol.Des_29_199 |
| Author(s) : Andersson CD , Hillgren JM , Lindgren C , Qian W , Akfur C , Berg L , Ekstrom F , Linusson A |
| Ref : J Comput Aided Mol Des , 29 :199 , 2015 |
| Abstract : Andersson_2015_J.Comput.Aided.Mol.Des_29_199 |
| ESTHER : Andersson_2015_J.Comput.Aided.Mol.Des_29_199 |
| PubMedSearch : Andersson_2015_J.Comput.Aided.Mol.Des_29_199 |
| PubMedID: 25351962 |
| Title : Acetylcholinesterases from the Disease Vectors Aedes aegypti and Anopheles gambiae: Functional Characterization and Comparisons with Vertebrate Orthologues - Engdahl_2015_PLoS.One_10_e0138598 |
| Author(s) : Engdahl C , Knutsson S , Fredriksson SA , Linusson A , Bucht G , Ekstrom F |
| Ref : PLoS ONE , 10 :e0138598 , 2015 |
| Abstract : Engdahl_2015_PLoS.One_10_e0138598 |
| ESTHER : Engdahl_2015_PLoS.One_10_e0138598 |
| PubMedSearch : Engdahl_2015_PLoS.One_10_e0138598 |
| PubMedID: 26447952 |
| Gene_locus related to this paper: aedae-ACHE1 , anoga-ACHE1 |
| Title : Divergent Structure-Activity Relationships of Structurally Similar Acetylcholinesterase Inhibitors - Andersson_2013_J.Med.Chem_56_7615 |
| Author(s) : Andersson CD , Forsgren N , Akfur C , Allgardsson A , Berg L , Engdahl C , Qian W , Ekstrom F , Linusson A |
| Ref : Journal of Medicinal Chemistry , 56 :7615 , 2013 |
| Abstract : Andersson_2013_J.Med.Chem_56_7615 |
| ESTHER : Andersson_2013_J.Med.Chem_56_7615 |
| PubMedSearch : Andersson_2013_J.Med.Chem_56_7615 |
| PubMedID: 23984975 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: possible implications for the HI-6 antidote substrate specificity - Artursson_2013_Biochem.Pharmacol_85_1389 |
| Author(s) : Artursson E , Andersson PO , Akfur C , Linusson A , Borjegren S , Ekstrom F |
| Ref : Biochemical Pharmacology , 85 :1389 , 2013 |
| Abstract : Artursson_2013_Biochem.Pharmacol_85_1389 |
| ESTHER : Artursson_2013_Biochem.Pharmacol_85_1389 |
| PubMedSearch : Artursson_2013_Biochem.Pharmacol_85_1389 |
| PubMedID: 23376121 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Effects of Anticholinesterases on Catalysis and Induced Conformational Change of the Peripheral Anionic Site of Murine Acetylcholinesterase - Tong_2013_Pestic.Biochem.Physiol_106_79 |
| Author(s) : Tong F , Islam RM , Carlier PR , Ma M , Ekstrom F , Bloomquist JR |
| Ref : Pesticide Biochemistry and Physiology , 106 :79 , 2013 |
| Abstract : Tong_2013_Pestic.Biochem.Physiol_106_79 |
| ESTHER : Tong_2013_Pestic.Biochem.Physiol_106_79 |
| PubMedSearch : Tong_2013_Pestic.Biochem.Physiol_106_79 |
| PubMedID: 24003261 |
| Title : Evaluation of novel carbamate insecticides for neurotoxicity to non-target species - Jiang_2013_Pestic.Biochem.Physiol_106_156 |
| Author(s) : Jiang Y , Swale D , Carlier PR , Hartsel JA , Ma M , Ekstrom F , Bloomquist JR |
| Ref : Pesticide Biochemistry and Physiology , 106 :156 , 2013 |
| Abstract : Jiang_2013_Pestic.Biochem.Physiol_106_156 |
| ESTHER : Jiang_2013_Pestic.Biochem.Physiol_106_156 |
| PubMedSearch : Jiang_2013_Pestic.Biochem.Physiol_106_156 |
| PubMedID: |
| Title : Similar but different: thermodynamic and structural characterization of a pair of enantiomers binding to acetylcholinesterase - Berg_2012_Angew.Chem.Int.Ed.Engl_51_12716 |
| Author(s) : Berg L , Niemiec MS , Qian W , Andersson CD , Wittung-Stafshede P , Ekstrom F , Linusson A |
| Ref : Angew Chem Int Ed Engl , 51 :12716 , 2012 |
| Abstract : Berg_2012_Angew.Chem.Int.Ed.Engl_51_12716 |
| ESTHER : Berg_2012_Angew.Chem.Int.Ed.Engl_51_12716 |
| PubMedSearch : Berg_2012_Angew.Chem.Int.Ed.Engl_51_12716 |
| PubMedID: 23161758 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Targeting acetylcholinesterase: identification of chemical leads by high throughput screening, structure determination and molecular modeling - Berg_2011_PLoS.One_6_e26039 |
| Author(s) : Berg L , Andersson CD , Artursson E , Hornberg A , Tunemalm AK , Linusson A , Ekstrom F |
| Ref : PLoS ONE , 6 :e26039 , 2011 |
| Abstract : Berg_2011_PLoS.One_6_e26039 |
| ESTHER : Berg_2011_PLoS.One_6_e26039 |
| PubMedSearch : Berg_2011_PLoS.One_6_e26039 |
| PubMedID: 22140425 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Crystal structures of oxime-bound fenamiphos-acetylcholinesterases: reactivation involving flipping of the His447 ring to form a reactive Glu334-His447-oxime triad - Hornberg_2010_Biochem.Pharmacol_79_507 |
| Author(s) : Hornberg A , Artursson E , Warme R , Pang YP , Ekstrom F |
| Ref : Biochemical Pharmacology , 79 :507 , 2010 |
| Abstract : Hornberg_2010_Biochem.Pharmacol_79_507 |
| ESTHER : Hornberg_2010_Biochem.Pharmacol_79_507 |
| PubMedSearch : Hornberg_2010_Biochem.Pharmacol_79_507 |
| PubMedID: 19732756 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds - Wille_2010_Biochem.Pharmacol_80_941 |
| Author(s) : Wille T , Ekstrom F , Lee JC , Pang YP , Thiermann H , Worek F |
| Ref : Biochemical Pharmacology , 80 :941 , 2010 |
| Abstract : Wille_2010_Biochem.Pharmacol_80_941 |
| ESTHER : Wille_2010_Biochem.Pharmacol_80_941 |
| PubMedSearch : Wille_2010_Biochem.Pharmacol_80_941 |
| PubMedID: 20510679 |
| Title : Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases - Pang_2009_PLoS.One_4_e6851 |
| Author(s) : Pang YP , Ekstrom F , Polsinelli GA , Gao Y , Rana S , Hua DH , Andersson B , Andersson PO , Peng L , Singh SK , Mishra RK , Zhu KY , Fallon AM , Ragsdale DW , Brimijoin S |
| Ref : PLoS ONE , 4 :e6851 , 2009 |
| Abstract : Pang_2009_PLoS.One_4_e6851 |
| ESTHER : Pang_2009_PLoS.One_4_e6851 |
| PubMedSearch : Pang_2009_PLoS.One_4_e6851 |
| PubMedID: 19714254 |
| Gene_locus related to this paper: mouse-ACHE , mouse-acnt1 |
| Title : Structure of HI-6*sarin-acetylcholinesterase determined by X-ray crystallography and molecular dynamics simulation: reactivator mechanism and design - Ekstrom_2009_PLoS.One_4_e5957 |
| Author(s) : Ekstrom F , Hornberg A , Artursson E , Hammarstrom LG , Schneider G , Pang YP |
| Ref : PLoS ONE , 4 :e5957 , 2009 |
| Abstract : Ekstrom_2009_PLoS.One_4_e5957 |
| ESTHER : Ekstrom_2009_PLoS.One_4_e5957 |
| PubMedSearch : Ekstrom_2009_PLoS.One_4_e5957 |
| PubMedID: 19536291 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Reactivation of tabun-hAChE investigated by structurally analogous oximes and mutagenesis - Artursson_2009_Toxicology_265_108 |
| Author(s) : Artursson E , Akfur C , Hornberg A , Worek F , Ekstrom F |
| Ref : Toxicology , 265 :108 , 2009 |
| Abstract : Artursson_2009_Toxicology_265_108 |
| ESTHER : Artursson_2009_Toxicology_265_108 |
| PubMedSearch : Artursson_2009_Toxicology_265_108 |
| PubMedID: 19761810 |
| Title : Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation - Carletti_2008_J.Am.Chem.Soc_130_16011 |
| Author(s) : Carletti E , Li H , Li B , Ekstrom F , Nicolet Y , Loiodice M , Gillon E , Froment MT , Lockridge O , Schopfer LM , Masson P , Nachon F |
| Ref : Journal of the American Chemical Society , 130 :16011 , 2008 |
| Abstract : Carletti_2008_J.Am.Chem.Soc_130_16011 |
| ESTHER : Carletti_2008_J.Am.Chem.Soc_130_16011 |
| PubMedSearch : Carletti_2008_J.Am.Chem.Soc_130_16011 |
| PubMedID: 18975951 |
| Gene_locus related to this paper: human-BCHE , mouse-ACHE |
| Title : Novel nerve-agent antidote design based on crystallographic and mass spectrometric analyses of tabun-conjugated acetylcholinesterase in complex with antidotes - Ekstrom_2007_Clin.Pharmacol.Ther_82_282 |
| Author(s) : Ekstrom F , Astot C , Pang YP |
| Ref : Clinical Pharmacology & Therapeutics , 82 :282 , 2007 |
| Abstract : Ekstrom_2007_Clin.Pharmacol.Ther_82_282 |
| ESTHER : Ekstrom_2007_Clin.Pharmacol.Ther_82_282 |
| PubMedSearch : Ekstrom_2007_Clin.Pharmacol.Ther_82_282 |
| PubMedID: 17443135 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Crystal structures of acetylcholinesterase in complex with organophosphorus compounds suggest that the acyl pocket modulates the aging reaction by precluding the formation of the trigonal bipyramidal transition state - Hornberg_2007_Biochemistry_46_4815 |
| Author(s) : Hornberg A , Tunemalm AK , Ekstrom F |
| Ref : Biochemistry , 46 :4815 , 2007 |
| Abstract : Hornberg_2007_Biochemistry_46_4815 |
| ESTHER : Hornberg_2007_Biochemistry_46_4815 |
| PubMedSearch : Hornberg_2007_Biochemistry_46_4815 |
| PubMedID: 17402711 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates - Ekstrom_2006_Biochem.Pharmacol_72_597 |
| Author(s) : Ekstrom F , Pang YP , Boman M , Artursson E , Akfur C , Borjegren S |
| Ref : Biochemical Pharmacology , 72 :597 , 2006 |
| Abstract : Ekstrom_2006_Biochem.Pharmacol_72_597 |
| ESTHER : Ekstrom_2006_Biochem.Pharmacol_72_597 |
| PubMedSearch : Ekstrom_2006_Biochem.Pharmacol_72_597 |
| PubMedID: 16876764 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Structural changes of phenylalanine 338 and histidine 447 revealed by the crystal structures of tabun-inhibited murine acetylcholinesterase - Ekstrom_2006_Biochemistry_45_74 |
| Author(s) : Ekstrom F , Akfur C , Tunemalm AK , Lundberg S |
| Ref : Biochemistry , 45 :74 , 2006 |
| Abstract : Ekstrom_2006_Biochemistry_45_74 |
| ESTHER : Ekstrom_2006_Biochemistry_45_74 |
| PubMedSearch : Ekstrom_2006_Biochemistry_45_74 |
| PubMedID: 16388582 |
| Gene_locus related to this paper: mouse-ACHE |