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Title: A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genomeMural RJ , Adams MD , Myers EW , Smith HO , Miklos GL , Wides R , Halpern A , Li PW , Sutton GG and Stephenson LD <169 more author(s)> Mural RJ , Adams MD , Myers EW , Smith HO , Miklos GL , Wides R , Halpern A , Li PW , Sutton GG , Nadeau J , Salzberg SL , Holt RA , Kodira CD , Lu F , Chen L , Deng Z , Evangelista CC , Gan W , Heiman TJ , Li J , Li Z , Merkulov GV , Milshina NV , Naik AK , Qi R , Shue BC , Wang A , Wang J , Wang X , Yan X , Ye J , Yooseph S , Zhao Q , Zheng L , Zhu SC , Biddick K , Bolanos R , Delcher AL , Dew IM , Fasulo D , Flanigan MJ , Huson DH , Kravitz SA , Miller JR , Mobarry CM , Reinert K , Remington KA , Zhang Q , Zheng XH , Nusskern DR , Lai Z , Lei Y , Zhong W , Yao A , Guan P , Ji RR , Gu Z , Wang ZY , Zhong F , Xiao C , Chiang CC , Yandell M , Wortman JR , Amanatides PG , Hladun SL , Pratts EC , Johnson JE , Dodson KL , Woodford KJ , Evans CA , Gropman B , Rusch DB , Venter E , Wang M , Smith TJ , Houck JT , Tompkins DE , Haynes C , Jacob D , Chin SH , Allen DR , Dahlke CE , Sanders R , Li K , Liu X , Levitsky AA , Majoros WH , Chen Q , Xia AC , Lopez JR , Donnelly MT , Newman MH , Glodek A , Kraft CL , Nodell M , Ali F , An HJ , Baldwin-Pitts D , Beeson KY , Cai S , Carnes M , Carver A , Caulk PM , Center A , Chen YH , Cheng ML , Coyne MD , Crowder M , Danaher S , Davenport LB , Desilets R , Dietz SM , Doup L , Dullaghan P , Ferriera S , Fosler CR , Gire HC , Gluecksmann A , Gocayne JD , Gray J , Hart B , Haynes J , Hoover J , Howland T , Ibegwam C , Jalali M , Johns D , Kline L , Ma DS , MacCawley S , Magoon A , Mann F , May D , McIntosh TC , Mehta S , Moy L , Moy MC , Murphy BJ , Murphy SD , Nelson KA , Nuri Z , Parker KA , Prudhomme AC , Puri VN , Qureshi H , Raley JC , Reardon MS , Regier MA , Rogers YH , Romblad DL , Schutz J , Scott JL , Scott R , Sitter CD , Smallwood M , Sprague AC , Stewart E , Strong RV , Suh E , Sylvester K , Thomas R , Tint NN , Tsonis C , Wang G , Williams MS , Williams SM , Windsor SM , Wolfe K , Wu MM , Zaveri J , Chaturvedi K , Gabrielian AE , Ke Z , Sun J , Subramanian G , Venter JC , Pfannkoch CM , Barnstead M , Stephenson LD (- 169) Ref: Science, 296 :1661, 2002 : PubMed Abstract ESTHER: Mural_2002_Science_296_1661 PubMedSearch: Mural 2002 Science 296 1661 PubMedID: 12040188 Gene_locus related to this paper: mouse-ABH15 ,
mouse-Ces3b ,
mouse-Ces4a ,
mouse-dpp4 ,
mouse-FAP ,
mouse-Lipg ,
mouse-Q8C1A9 ,
mouse-rbbp9 ,
mouse-SERHL ,
mouse-SPG21 ,
mouse-w4vsp6 Abstract
The high degree of similarity between the mouse and human genomes is demonstrated through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a whole-genome shotgun assembly of the mouse genome. The mouse genome is about 10% smaller than the human genome, owing to a lower repetitive DNA content. Comparison of the structure and protein-coding potential of Mmu 16 with that of the homologous segments of the human genome identifies regions of conserved synteny with human chromosomes (Hsa) 3, 8, 12, 16, 21, and 22. Gene content and order are highly conserved between Mmu 16 and the syntenic blocks of the human genome. Of the 731 predicted genes on Mmu 16, 509 align with orthologs on the corresponding portions of the human genome, 44 are likely paralogous to these genes, and 164 genes have homologs elsewhere in the human genome; there are 14 genes for which we could find no human counterpart.
Title: The genome sequence of Drosophila melanogasterAdams MD , Celniker SE , Holt RA , Evans CA , Gocayne JD , Amanatides PG , Scherer SE , Li PW , Hoskins RA and Venter JC <185 more author(s)> Adams MD , Celniker SE , Holt RA , Evans CA , Gocayne JD , Amanatides PG , Scherer SE , Li PW , Hoskins RA , Galle RF , George RA , Lewis SE , Richards S , Ashburner M , Henderson SN , Sutton GG , Wortman JR , Yandell MD , Zhang Q , Chen LX , Brandon RC , Rogers YH , Blazej RG , Champe M , Pfeiffer BD , Wan KH , Doyle C , Baxter EG , Helt G , Nelson CR , Gabor GL , Abril JF , Agbayani A , An HJ , Andrews-Pfannkoch C , Baldwin D , Ballew RM , Basu A , Baxendale J , Bayraktaroglu L , Beasley EM , Beeson KY , Benos PV , Berman BP , Bhandari D , Bolshakov S , Borkova D , Botchan MR , Bouck J , Brokstein P , Brottier P , Burtis KC , Busam DA , Butler H , Cadieu E , Center A , Chandra I , Cherry JM , Cawley S , Dahlke C , Davenport LB , Davies P , de Pablos B , Delcher A , Deng Z , Mays AD , Dew I , Dietz SM , Dodson K , Doup LE , Downes M , Dugan-Rocha S , Dunkov BC , Dunn P , Durbin KJ , Evangelista CC , Ferraz C , Ferriera S , Fleischmann W , Fosler C , Gabrielian AE , Garg NS , Gelbart WM , Glasser K , Glodek A , Gong F , Gorrell JH , Gu Z , Guan P , Harris M , Harris NL , Harvey D , Heiman TJ , Hernandez JR , Houck J , Hostin D , Houston KA , Howland TJ , Wei MH , Ibegwam C , Jalali M , Kalush F , Karpen GH , Ke Z , Kennison JA , Ketchum KA , Kimmel BE , Kodira CD , Kraft C , Kravitz S , Kulp D , Lai Z , Lasko P , Lei Y , Levitsky AA , Li J , Li Z , Liang Y , Lin X , Liu X , Mattei B , McIntosh TC , McLeod MP , McPherson D , Merkulov G , Milshina NV , Mobarry C , Morris J , Moshrefi A , Mount SM , Moy M , Murphy B , Murphy L , Muzny DM , Nelson DL , Nelson DR , Nelson KA , Nixon K , Nusskern DR , Pacleb JM , Palazzolo M , Pittman GS , Pan S , Pollard J , Puri V , Reese MG , Reinert K , Remington K , Saunders RD , Scheeler F , Shen H , Shue BC , Siden-Kiamos I , Simpson M , Skupski MP , Smith T , Spier E , Spradling AC , Stapleton M , Strong R , Sun E , Svirskas R , Tector C , Turner R , Venter E , Wang AH , Wang X , Wang ZY , Wassarman DA , Weinstock GM , Weissenbach J , Williams SM , WoodageT , Worley KC , Wu D , Yang S , Yao QA , Ye J , Yeh RF , Zaveri JS , Zhan M , Zhang G , Zhao Q , Zheng L , Zheng XH , Zhong FN , Zhong W , Zhou X , Zhu S , Zhu X , Smith HO , Gibbs RA , Myers EW , Rubin GM , Venter JC (- 185) Ref: Science, 287 :2185, 2000 : PubMed Abstract ESTHER: Adams_2000_Science_287_2185 PubMedSearch: Adams 2000 Science 287 2185 PubMedID: 10731132 Gene_locus related to this paper: drome-1vite ,
drome-2vite ,
drome-3vite ,
drome-a1z6g9 ,
drome-abhd2 ,
drome-ACHE ,
drome-b6idz4 ,
drome-BEM46 ,
drome-CG5707 ,
drome-CG5704 ,
drome-CG1309 ,
drome-CG1882 ,
drome-CG1986 ,
drome-CG2059 ,
drome-CG2493 ,
drome-CG2528 ,
drome-CG2772 ,
drome-CG3160 ,
drome-CG3344 ,
drome-CG3523 ,
drome-CG3524 ,
drome-CG3734 ,
drome-CG3739 ,
drome-CG3744 ,
drome-CG3841 ,
drome-CG4267 ,
drome-CG4382 ,
drome-CG4390 ,
drome-CG4572 ,
drome-CG4582 ,
drome-CG4851 ,
drome-CG4979 ,
drome-CG5068 ,
drome-CG5162 ,
drome-CG5355 ,
drome-CG5377 ,
drome-CG5397 ,
drome-CG5412 ,
drome-CG5665 ,
drome-CG5932 ,
drome-CG5966 ,
drome-CG6018 ,
drome-CG6113 ,
drome-CG6271 ,
drome-CG6283 ,
drome-CG6295 ,
drome-CG6296 ,
drome-CG6414 ,
drome-CG6431 ,
drome-CG6472 ,
drome-CG6567 ,
drome-CG6675 ,
drome-CG6753 ,
drome-CG6847 ,
drome-CG7329 ,
drome-CG7367 ,
drome-CG7529 ,
drome-CG7632 ,
drome-CG8058 ,
drome-CG8093 ,
drome-CG8233 ,
drome-CG8424 ,
drome-CG8425 ,
drome-CG9059 ,
drome-CG9186 ,
drome-CG9287 ,
drome-CG9289 ,
drome-CG9542 ,
drome-CG9858 ,
drome-CG9953 ,
drome-CG9966 ,
drome-CG10116 ,
drome-CG10163 ,
drome-CG10175 ,
drome-CG10339 ,
drome-CG10357 ,
drome-CG10982 ,
drome-CG11034 ,
drome-CG11055 ,
drome-CG11309 ,
drome-CG11319 ,
drome-CG11406 ,
drome-CG11598 ,
drome-CG11600 ,
drome-CG11608 ,
drome-CG11626 ,
drome-CG11935 ,
drome-CG12108 ,
drome-CG12869 ,
drome-CG13282 ,
drome-CG13562 ,
drome-CG13772 ,
drome-CG14034 ,
drome-nlg3 ,
drome-CG14717 ,
drome-CG15101 ,
drome-CG15102 ,
drome-CG15106 ,
drome-CG15111 ,
drome-CG15820 ,
drome-CG15821 ,
drome-CG15879 ,
drome-CG17097 ,
drome-CG17099 ,
drome-CG17101 ,
drome-CG17191 ,
drome-CG17192 ,
drome-CG17292 ,
drome-CG18258 ,
drome-CG18284 ,
drome-CG18301 ,
drome-CG18302 ,
drome-CG18493 ,
drome-CG18530 ,
drome-CG18641 ,
drome-CG18815 ,
drome-CG31089 ,
drome-CG31091 ,
drome-CG32333 ,
drome-CG32483 ,
drome-CG33174 ,
drome-dnlg1 ,
drome-este4 ,
drome-este6 ,
drome-GH02384 ,
drome-GH02439 ,
drome-glita ,
drome-KRAKEN ,
drome-lip1 ,
drome-LIP2 ,
drome-lip3 ,
drome-MESK2 ,
drome-nrtac ,
drome-OME ,
drome-q7k274 ,
drome-Q9VJN0 ,
drome-Q8IP31 ,
drome-q9vux3 Abstract
The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the approximately 120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps; however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes approximately 13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.
