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| Title : N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward an alpha7 nicotinic acetylcholine receptor agonist preclinical candidate - Zanaletti_2012_J.Med.Chem_55_10277 |
| Author(s) : Zanaletti R , Bettinetti L , Castaldo C , Ceccarelli I , Cocconcelli G , Comery TA , Dunlop J , Genesio E , Ghiron C , Haydar SN , Jow F , Maccari L , Micco I , Nencini A , Pratelli C , Scali C , Turlizzi E , Valacchi M |
| Ref : Journal of Medicinal Chemistry , 55 :10277 , 2012 |
| Abstract : Zanaletti_2012_J.Med.Chem_55_10277 |
| ESTHER : Zanaletti_2012_J.Med.Chem_55_10277 |
| PubMedSearch : Zanaletti_2012_J.Med.Chem_55_10277 |
| PubMedID: 23083093 |
| Title : Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789) - Zanaletti_2012_J.Med.Chem_55_4806 |
| Author(s) : Zanaletti R , Bettinetti L , Castaldo C , Cocconcelli G , Comery T , Dunlop J , Gaviraghi G , Ghiron C , Haydar SN , Jow F , Maccari L , Micco I , Nencini A , Scali C , Turlizzi E , Valacchi M |
| Ref : Journal of Medicinal Chemistry , 55 :4806 , 2012 |
| Abstract : Zanaletti_2012_J.Med.Chem_55_4806 |
| ESTHER : Zanaletti_2012_J.Med.Chem_55_4806 |
| PubMedSearch : Zanaletti_2012_J.Med.Chem_55_4806 |
| PubMedID: 22468936 |
| Title : Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914\/SEN34625 - Marquis_2011_Psychopharmacology.(Berl)_218_635 |
| Author(s) : Marquis KL , Comery TA , Jow F , Navarra RL , Grauer SM , Pulicicchio C , Kelley C , Brennan JA , Roncarati R , Scali C , Haydar S , Ghiron C , Terstappen GC , Dunlop J |
| Ref : Psychopharmacology (Berl) , 218 :635 , 2011 |
| Abstract : Marquis_2011_Psychopharmacology.(Berl)_218_635 |
| ESTHER : Marquis_2011_Psychopharmacology.(Berl)_218_635 |
| PubMedSearch : Marquis_2011_Psychopharmacology.(Berl)_218_635 |
| PubMedID: 21643676 |
| Title : Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625\/WYE-103914) - Ghiron_2010_J.Med.Chem_53_4379 |
| Author(s) : Ghiron C , Haydar SN , Aschmies S , Bothmann H , Castaldo C , Cocconcelli G , Comery TA , Di L , Dunlop J , Lock T , Kramer A , Kowal D , Jow F , Grauer S , Harrison B , La Rosa S , Maccari L , Marquis KL , Micco I , Nencini A , Quinn J , Robichaud AJ , Roncarati R , Scali C , Terstappen GC , Turlizzi E , Valacchi M , Varrone M , Zanaletti R , Zanelli U |
| Ref : Journal of Medicinal Chemistry , 53 :4379 , 2010 |
| Abstract : Ghiron_2010_J.Med.Chem_53_4379 |
| ESTHER : Ghiron_2010_J.Med.Chem_53_4379 |
| PubMedSearch : Ghiron_2010_J.Med.Chem_53_4379 |
| PubMedID: 20465311 |
| Title : Poster: In vitro pharmacological characterization and pro-cognitive effects of the selective alpha-7 nicotinic agonist WYE-103914 - |
| Author(s) : Dunlop J , Comery TA , Lock T , Kramer A , Kowal D , Yeola S , Jow F , Aschmies S , Lin Q , Beyer CE , Brennan J , Kelley C , Roncarati R , Scali C , Haydar S , Ghiron C , Marquis KL , Harrison B , Robichaud A , Terstappen GC |
| Ref : Biochemical Pharmacology , 78 :911 , 2009 |
| PubMedID: |
| Title : Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders - Roncarati_2009_J.Pharmacol.Exp.Ther_329_459 |
| Author(s) : Roncarati R , Scali C , Comery TA , Grauer SM , Aschmi S , Bothmann H , Jow B , Kowal D , Gianfriddo M , Kelley C , Zanelli U , Ghiron C , Haydar S , Dunlop J , Terstappen GC |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 329 :459 , 2009 |
| Abstract : Roncarati_2009_J.Pharmacol.Exp.Ther_329_459 |
| ESTHER : Roncarati_2009_J.Pharmacol.Exp.Ther_329_459 |
| PubMedSearch : Roncarati_2009_J.Pharmacol.Exp.Ther_329_459 |
| PubMedID: 19223665 |
| Title : Poster: Characterization of the alpha-7 nicotinic receptor agonist WYE-103914 in models relevant to schizophrenia and interaction with antipsychotics - |
| Author(s) : Marquis KL , Comery TA , Navarra RL , Leiser S , Grauer SM , Pulicicchio C , Kelley C , Roncarati R , Scali C , Haydar S , Ghiron C , Harrison B , Robichaud A , Terstappen GC , Dunlop J |
| Ref : Biochemical Pharmacology , 78 :911 , 2009 |
| PubMedID: |
| Title : SAR and biological evaluation of SEN12333\/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist - Haydar_2009_Bioorg.Med.Chem_17_5247 |
| Author(s) : Haydar SN , Ghiron C , Bettinetti L , Bothmann H , Comery TA , Dunlop J , La Rosa S , Micco I , Pollastrini M , Quinn J , Roncarati R , Scali C , Valacchi M , Varrone M , Zanaletti R |
| Ref : Bioorganic & Medicinal Chemistry , 17 :5247 , 2009 |
| Abstract : Haydar_2009_Bioorg.Med.Chem_17_5247 |
| ESTHER : Haydar_2009_Bioorg.Med.Chem_17_5247 |
| PubMedSearch : Haydar_2009_Bioorg.Med.Chem_17_5247 |
| PubMedID: 19515567 |