Full name : Gopalakrishnan Murali
First name : Murali
Mail : Department of Neuroscience Research, Abbott Laboratories, Abbott Park, Illinois
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Country : USA
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| Title : Effects of the novel alpha7 nicotinic acetylcholine receptor agonist ABT-107 on sensory gating in DBA\/2 mice: pharmacodynamic characterization - Radek_2012_J.Pharmacol.Exp.Ther_343_736 |
| Author(s) : Radek RJ , Robb HM , Stevens KE , Gopalakrishnan M , Bitner RS |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 343 :736 , 2012 |
| Abstract : Radek_2012_J.Pharmacol.Exp.Ther_343_736 |
| ESTHER : Radek_2012_J.Pharmacol.Exp.Ther_343_736 |
| PubMedSearch : Radek_2012_J.Pharmacol.Exp.Ther_343_736 |
| PubMedID: 22988063 |
| Title : Effects of alpha7 nicotinic acetylcholine receptor agonists on antipsychotic efficacy in a preclinical mouse model of psychosis - Kohlhaas_2012_Psychopharmacology.(Berl)_220_823 |
| Author(s) : Kohlhaas KL , Bitner RS , Gopalakrishnan M , Rueter LE |
| Ref : Psychopharmacology (Berl) , 220 :823 , 2012 |
| Abstract : Kohlhaas_2012_Psychopharmacology.(Berl)_220_823 |
| ESTHER : Kohlhaas_2012_Psychopharmacology.(Berl)_220_823 |
| PubMedSearch : Kohlhaas_2012_Psychopharmacology.(Berl)_220_823 |
| PubMedID: 22038534 |
| Title : SAR of alpha7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore - Schrimpf_2012_Bioorg.Med.Chem.Lett_22_1633 |
| Author(s) : Schrimpf MR , Sippy KB , Briggs CA , Anderson DJ , Li T , Ji J , Frost JM , Surowy CS , Bunnelle WH , Gopalakrishnan M , Meyer MD |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :1633 , 2012 |
| Abstract : Schrimpf_2012_Bioorg.Med.Chem.Lett_22_1633 |
| ESTHER : Schrimpf_2012_Bioorg.Med.Chem.Lett_22_1633 |
| PubMedSearch : Schrimpf_2012_Bioorg.Med.Chem.Lett_22_1633 |
| PubMedID: 22281189 |
| Title : Poster: A-582941, a pro-cognitive alpha7 nAChR agonist, differentially modulates mitochondrial membrane potential - |
| Author(s) : Namovic M , Hu M , Abraham V , Towne D , Lee C-H , Gopalakrishnan M , Esbenshade T , Donnelly-Roberts D |
| Ref : Biochemical Pharmacology , 82 :1027 , 2011 |
| PubMedID: |
| Title : Functional characterization and high-throughput screening of positive allosteric modulators of alpha7 nicotinic acetylcholine receptors in IMR-32 neuroblastoma cells - Gopalakrishnan_2011_Assay.Drug.Dev.Technol_9_635 |
| Author(s) : Gopalakrishnan SM , Philip BM , Gronlien JH , Malysz J , Anderson DJ , Gopalakrishnan M , Warrior U , Burns DJ |
| Ref : Assay Drug Dev Technol , 9 :635 , 2011 |
| Abstract : Gopalakrishnan_2011_Assay.Drug.Dev.Technol_9_635 |
| ESTHER : Gopalakrishnan_2011_Assay.Drug.Dev.Technol_9_635 |
| PubMedSearch : Gopalakrishnan_2011_Assay.Drug.Dev.Technol_9_635 |
| PubMedID: 21309712 |
| Title : Structure-activity studies of diazabicyclo[3.3.0]octane-substituted pyrazines and pyridines as potent alpha4beta2 nicotinic acetylcholine receptor ligands - Scanio_2011_J.Med.Chem_54_7678 |
| Author(s) : Scanio MJ , Shi L , Bunnelle WH , Anderson DJ , Helfrich RJ , Malysz J , Thorin-Hagene KK , Van Handel CE , Marsh KC , Lee CH , Gopalakrishnan M |
| Ref : Journal of Medicinal Chemistry , 54 :7678 , 2011 |
| Abstract : Scanio_2011_J.Med.Chem_54_7678 |
| ESTHER : Scanio_2011_J.Med.Chem_54_7678 |
| PubMedSearch : Scanio_2011_J.Med.Chem_54_7678 |
| PubMedID: 21962147 |
| Title : alpha4beta2 neuronal nicotinic receptor positive allosteric modulation: an approach for improving the therapeutic index of alpha4beta2 nAChR agonists in pain - Lee_2011_Biochem.Pharmacol_82(8)_959 |
| Author(s) : Lee CH , Zhu C , Malysz J , Campbell T , Shaughnessy T , Honore P , Polakowski J , Gopalakrishnan M |
| Ref : Biochemical Pharmacology , 82 :959 , 2011 |
| Abstract : Lee_2011_Biochem.Pharmacol_82(8)_959 |
| ESTHER : Lee_2011_Biochem.Pharmacol_82(8)_959 |
| PubMedSearch : Lee_2011_Biochem.Pharmacol_82(8)_959 |
| PubMedID: 21763685 |
| Title : Role of alpha7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-alpha (TNF-alpha) as revealed by subtype selective agonists - Li_2011_J.Neuroimmunol_239_37 |
| Author(s) : Li J , Mathieu SL , Harris R , Ji J , Anderson DJ , Malysz J , Bunnelle WH , Waring JF , Marsh KC , Murtaza A , Olson LM , Gopalakrishnan M |
| Ref : Journal of Neuroimmunology , 239 :37 , 2011 |
| Abstract : Li_2011_J.Neuroimmunol_239_37 |
| ESTHER : Li_2011_J.Neuroimmunol_239_37 |
| PubMedSearch : Li_2011_J.Neuroimmunol_239_37 |
| PubMedID: 21911260 |
| Title : Potentiation of analgesic efficacy but not side effects: co-administration of an alpha4beta2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats - Zhu_2011_Biochem.Pharmacol_82(8)_967 |
| Author(s) : Zhu CZ , Chin CL , Rustay NR , Zhong C , Mikusa J , Chandran P , Salyers A , Gomez E , Simler G , Lewis LG , Gauvin D , Baker S , Pai M , Tovcimak A , Brown J , Komater V , Fox GB , Decker MW , Jacobson PB , Gopalakrishnan M , Lee CH , Honore P |
| Ref : Biochemical Pharmacology , 82 :967 , 2011 |
| Abstract : Zhu_2011_Biochem.Pharmacol_82(8)_967 |
| ESTHER : Zhu_2011_Biochem.Pharmacol_82(8)_967 |
| PubMedSearch : Zhu_2011_Biochem.Pharmacol_82(8)_967 |
| PubMedID: 21620806 |
| Title : Poster: In Vitro neuroprotective effects of ABT-779, a positive allosteric modulator of alpha7 nAChRs - |
| Author(s) : Hu M , Li J , Malysz J , Esbenshade TA , Lee C-H , Gopalakrishnan M |
| Ref : Biochemical Pharmacology , 82 :1042 , 2011 |
| PubMedID: |
| Title : Poster: alpha7 NNR allosteric modulation in behavioral models of cognition - |
| Author(s) : Kohlhaas KL , Robb H , Roderwald V , Markosyan S , Salte K , Bitner RS , Mohler E , Terry AV, Jr. , Buccafusco JJ , Rueter LE , Lee L , Gopalakrishnan M |
| Ref : Biochemical Pharmacology , 82 :1042 , 2011 |
| PubMedID: |
| Title : Nicotinic acetylcholine receptors as therapeutic targets: emerging frontiers in basic research and clinical science--Editorial Comments - |
| Author(s) : Donnelly-Roberts D , Bertrand D , Gopalakrishnan M |
| Ref : Biochemical Pharmacology , 82 :797 , 2011 |
| PubMedID: 21600889 |
| Title : Poster: In vitro pharmacological characterization of ABT-779, a novel positive allosteric modulator of alpha7 nAChRs - |
| Author(s) : Malysz J , Gronlien JH , Briggs CA , Anderson DJ , El-Kouhen R , Drescher K , Ween H , Thorin-Hagene K , Mortell K , Lee C-H , Gopalakrishnan M |
| Ref : Biochemical Pharmacology , 82 :1030 , 2011 |
| PubMedID: |
| Title : In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107 - Malysz_2010_J.Pharmacol.Exp.Ther_334_863 |
| Author(s) : Malysz J , Anderson DJ , Gronlien JH , Ji J , Bunnelle WH , Hakerud M , Thorin-Hagene K , Ween H , Helfrich R , Hu M , Gubbins E , Gopalakrishnan S , Puttfarcken PS , Briggs CA , Li J , Meyer MD , Dyhring T , Ahring PK , Nielsen EO , Peters D , Timmermann DB , Gopalakrishnan M |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 334 :863 , 2010 |
| Abstract : Malysz_2010_J.Pharmacol.Exp.Ther_334_863 |
| ESTHER : Malysz_2010_J.Pharmacol.Exp.Ther_334_863 |
| PubMedSearch : Malysz_2010_J.Pharmacol.Exp.Ther_334_863 |
| PubMedID: 20504915 |
| Title : Importance of M2-M3 loop in governing properties of genistein at the alpha7 nicotinic acetylcholine receptor inferred from alpha7\/5-HT3A chimera - Gronlien_2010_Eur.J.Pharmacol_647_37 |
| Author(s) : Gronlien JH , Ween H , Thorin-Hagene K , Cassar S , Li J , Briggs CA , Gopalakrishnan M , Malysz J |
| Ref : European Journal of Pharmacology , 647 :37 , 2010 |
| Abstract : Gronlien_2010_Eur.J.Pharmacol_647_37 |
| ESTHER : Gronlien_2010_Eur.J.Pharmacol_647_37 |
| PubMedSearch : Gronlien_2010_Eur.J.Pharmacol_647_37 |
| PubMedID: 20816816 |
| Title : Alpha7 nAChR-mediated activation of MAP kinase pathways in PC12 cells - Gubbins_2010_Brain.Res_1328_1 |
| Author(s) : Gubbins EJ , Gopalakrishnan M , Li J |
| Ref : Brain Research , 1328 :1 , 2010 |
| Abstract : Gubbins_2010_Brain.Res_1328_1 |
| ESTHER : Gubbins_2010_Brain.Res_1328_1 |
| PubMedSearch : Gubbins_2010_Brain.Res_1328_1 |
| PubMedID: 20211606 |
| Title : Alpha3* and alpha 7 nAChR-mediated Ca2+ transient generation in IMR-32 neuroblastoma cells - Ween_2010_Neurochem.Int_57_269 |
| Author(s) : Ween H , Thorin-Hagene K , Andersen E , Gronlien JH , Lee CH , Gopalakrishnan M , Malysz J |
| Ref : Neurochem Int , 57 :269 , 2010 |
| Abstract : Ween_2010_Neurochem.Int_57_269 |
| ESTHER : Ween_2010_Neurochem.Int_57_269 |
| PubMedSearch : Ween_2010_Neurochem.Int_57_269 |
| PubMedID: 20558224 |
| Title : In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease - Bitner_2010_J.Pharmacol.Exp.Ther_334_875 |
| Author(s) : Bitner RS , Bunnelle WH , Decker MW , Drescher KU , Kohlhaas KL , Markosyan S , Marsh KC , Nikkel AL , Browman K , Radek R , Anderson DJ , Buccafusco JJ , Gopalakrishnan M |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 334 :875 , 2010 |
| Abstract : Bitner_2010_J.Pharmacol.Exp.Ther_334_875 |
| ESTHER : Bitner_2010_J.Pharmacol.Exp.Ther_334_875 |
| PubMedSearch : Bitner_2010_J.Pharmacol.Exp.Ther_334_875 |
| PubMedID: 20504913 |
| Title : Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands - Li_2010_Bioorg.Med.Chem.Lett_20_3636 |
| Author(s) : Li T , Bunnelle WH , Ryther KB , Anderson DJ , Malysz J , Helfrich R , Gronlien JH , Hakerud M , Peters D , Schrimpf MR , Gopalakrishnan M , Ji J |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :3636 , 2010 |
| Abstract : Li_2010_Bioorg.Med.Chem.Lett_20_3636 |
| ESTHER : Li_2010_Bioorg.Med.Chem.Lett_20_3636 |
| PubMedSearch : Li_2010_Bioorg.Med.Chem.Lett_20_3636 |
| PubMedID: 20472430 |
| Title : Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor - Mortell_2010_Bioorg.Med.Chem.Lett_20_104 |
| Author(s) : Mortell KH , Schrimpf MR , Bunnelle WH , Anderson DJ , Gronlien JH , Hagene KT , Gopalakrishnan M |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :104 , 2010 |
| Abstract : Mortell_2010_Bioorg.Med.Chem.Lett_20_104 |
| ESTHER : Mortell_2010_Bioorg.Med.Chem.Lett_20_104 |
| PubMedSearch : Mortell_2010_Bioorg.Med.Chem.Lett_20_104 |
| PubMedID: 19954975 |
| Title : Poster: Profile of A-716096, a novel thiazolylidine positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor - |
| Author(s) : Donnelly-Roberts D , Malysz J , Faghih R , Gronlien H , Haakerud M , Thorin-Hagne K , Ween H , Gopalakrishnan SM , Hu M , Li J , Anderson DJ , Kohlhaas KL , Namovic M , Radek R , Robb H , Briggs CA , Bitner RS , Bunnelle WH , Gopalakrishnan M |
| Ref : Biochemical Pharmacology , 78 :912 , 2009 |
| PubMedID: |
| Title : Poster: Positive allosteric modulation of alpha4\/beta2 nicotinic receptors potentiates some CNS effects of the alpha4\/beta2 agonist, ABT-594 - |
| Author(s) : Franklin SR , Mohler EG , Komater VA , Robb H , Radek RJ , Rustay NR , Brown JW , Gopalakrishnan M , Decker MW , Rueter LE |
| Ref : Biochemical Pharmacology , 78 :921 , 2009 |
| PubMedID: |
| Title : Pharmacology of alpha7 nicotinic acetylcholine receptor mediated extracellular signal-regulated kinase signalling in PC12 cells - El Kouhen_2009_Br.J.Pharmacol_156_638 |
| Author(s) : El Kouhen R , Hu M , Anderson DJ , Li J , Gopalakrishnan M |
| Ref : British Journal of Pharmacology , 156 :638 , 2009 |
| Abstract : El Kouhen_2009_Br.J.Pharmacol_156_638 |
| ESTHER : El Kouhen_2009_Br.J.Pharmacol_156_638 |
| PubMedSearch : El Kouhen_2009_Br.J.Pharmacol_156_638 |
| PubMedID: 19226255 |
| Title : Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor - Faghih_2009_J.Med.Chem_52_3377 |
| Author(s) : Faghih R , Gopalakrishnan SM , Gronlien JH , Malysz J , Briggs CA , Wetterstrand C , Ween H , Curtis MP , Sarris KA , Gfesser GA , El-Kouhen R , Robb HM , Radek RJ , Marsh KC , Bunnelle WH , Gopalakrishnan M |
| Ref : Journal of Medicinal Chemistry , 52 :3377 , 2009 |
| Abstract : Faghih_2009_J.Med.Chem_52_3377 |
| ESTHER : Faghih_2009_J.Med.Chem_52_3377 |
| PubMedSearch : Faghih_2009_J.Med.Chem_52_3377 |
| PubMedID: 19419141 |
| Title : Poster: Positive allosteric modulation of alpha7 neuronal nicotinic acetylcholine receptors: Lack of mechanism-based evidence for cytotoxicity in PC12 cells and rat primary cortical neurons - |
| Author(s) : Hu M , Gopalakrishnan M , Li J |
| Ref : Biochemical Pharmacology , 78 :904 , 2009 |
| PubMedID: |
| Title : Poster: Improving the efficacy-tolerability profile of nAChR agonists for the treatment of neuropathic pain in combination with positive allosteric modulators - |
| Author(s) : Lee C-H , Zhu C , Campbell T , Shaughnessy T , Honore P , Polakowski J , Gopalakrishnan M |
| Ref : Biochemical Pharmacology , 78 :920 , 2009 |
| PubMedID: |
| Title : Poster: Role of alpha-7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-alpha (TNF-alpha) as Revealed by subtype selective agonists - |
| Author(s) : Li J , Mathieu SL , Harris R , Ji J , Anderson DJ , Malysz J , Bunnelle WH , Waring JF , Marsh KC , Murtaza A , Olson LM , Gopalakrishnan M |
| Ref : Biochemical Pharmacology , 78 :924 , 2009 |
| PubMedID: |
| Title : Poster: In vitro pharmacological profile of a novel alpha4\/beta2 positive allosteric modulator NS9283 (A-969933) - |
| Author(s) : Malysz J , Dyhring T , Ahring PK , Olsen GM , Peters D , Gronlien JH , Wetterstrand C , Ween H , Haakerud M , Thorin-Hagene K , Andersen E , Anderson DJ , Hu M , Kroeger PE , Lee CHL , Gopalakrishnan M , Timmermann DB |
| Ref : Biochemical Pharmacology , 78 :919 , 2009 |
| PubMedID: |
| Title : Poster: Selectivity of ABT-089 for alpha4\/beta2* and alpha6\/beta2 nicotinic acetylcholine receptors in brain - |
| Author(s) : Marks MJ , Wageman CR , Grady SR , Gopalakrishnan M , Briggs CA |
| Ref : Biochemical Pharmacology , 78 :910 , 2009 |
| PubMedID: |
| Title : Positive allosteric modulation of alpha7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons - Hu_2009_Br.J.Pharmacol_158_1857 |
| Author(s) : Hu M , Gopalakrishnan M , Li J |
| Ref : British Journal of Pharmacology , 158 :1857 , 2009 |
| Abstract : Hu_2009_Br.J.Pharmacol_158_1857 |
| ESTHER : Hu_2009_Br.J.Pharmacol_158_1857 |
| PubMedSearch : Hu_2009_Br.J.Pharmacol_158_1857 |
| PubMedID: 20050184 |
| Title : Stimulation of dopamine release by nicotinic acetylcholine receptor ligands in rat brain slices correlates with the profile of high, but not low, sensitivity alpha4beta2 subunit combination - Anderson_2009_Biochem.Pharmacol_78(7)_844 |
| Author(s) : Anderson DJ , Malysz J , Gronlien JH , El Kouhen R , Hakerud M , Wetterstrand C , Briggs CA , Gopalakrishnan M |
| Ref : Biochemical Pharmacology , 78 :844 , 2009 |
| Abstract : Anderson_2009_Biochem.Pharmacol_78(7)_844 |
| ESTHER : Anderson_2009_Biochem.Pharmacol_78(7)_844 |
| PubMedSearch : Anderson_2009_Biochem.Pharmacol_78(7)_844 |
| PubMedID: 19555668 |
| Title : Poster: alpha3* and alpha7* nAChR mediated Ca2+ transient generation in neuroblastoma IMR-32 cells - |
| Author(s) : Ween H , Thorin-Hagene K , Andersen E , Gronlien JH , Lee L , Gopalakrishnan M , Malysz J |
| Ref : Biochemical Pharmacology , 78 :904 , 2009 |
| PubMedID: |
| Title : Nicotinic acetylcholine receptors as therapeutic targets: emerging frontiers in basic research and clinical science--editorial perspective - |
| Author(s) : Bertrand D , Gopalakrishnan M , Donnelly-Roberts D |
| Ref : Biochemical Pharmacology , 78 :657 , 2009 |
| PubMedID: 19576180 |
| Title : Poster: In vivo characterization of the co-administration of alpha4\/beta2 neuronal nicotinic receptor agonist and positive allosteric modulator in experimental pain in rats - |
| Author(s) : Zhu CZ , Chin C-l , Zhong C , Mikusa J , Chandran P , Salyers A , Wensink E , Silmer G , Lewis LG , Gauvin D , Baker S , Tovcimak A , Brown J , Rustay N , Fox GB , Decker MW , Lee C-H , Gopalakrishnan M , Honore P |
| Ref : Biochemical Pharmacology , 78 :920 , 2009 |
| PubMedID: |
| Title : Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo - Bitner_2009_Brain.Res_1265_65 |
| Author(s) : Bitner RS , Nikkel AL , Markosyan S , Otte S , Puttfarcken P , Gopalakrishnan M |
| Ref : Brain Research , 1265 :65 , 2009 |
| Abstract : Bitner_2009_Brain.Res_1265_65 |
| ESTHER : Bitner_2009_Brain.Res_1265_65 |
| PubMedSearch : Bitner_2009_Brain.Res_1265_65 |
| PubMedID: 19230830 |
| Title : Role of channel activation in cognitive enhancement mediated by alpha7 nicotinic acetylcholine receptors - Briggs_2009_Br.J.Pharmacol_158_1486 |
| Author(s) : Briggs CA , Gronlien JH , Curzon P , Timmermann DB , Ween H , Thorin-Hagene K , Kerr P , Anderson DJ , Malysz J , Dyhring T , Olsen GM , Peters D , Bunnelle WH , Gopalakrishnan M |
| Ref : British Journal of Pharmacology , 158 :1486 , 2009 |
| Abstract : Briggs_2009_Br.J.Pharmacol_158_1486 |
| ESTHER : Briggs_2009_Br.J.Pharmacol_158_1486 |
| PubMedSearch : Briggs_2009_Br.J.Pharmacol_158_1486 |
| PubMedID: 19845675 |
| Title : In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile - Malysz_2009_J.Pharmacol.Exp.Ther_330_257 |
| Author(s) : Malysz J , Gronlien JH , Anderson DJ , Hakerud M , Thorin-Hagene K , Ween H , Wetterstrand C , Briggs CA , Faghih R , Bunnelle WH , Gopalakrishnan M |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 330 :257 , 2009 |
| Abstract : Malysz_2009_J.Pharmacol.Exp.Ther_330_257 |
| ESTHER : Malysz_2009_J.Pharmacol.Exp.Ther_330_257 |
| PubMedSearch : Malysz_2009_J.Pharmacol.Exp.Ther_330_257 |
| PubMedID: 19389923 |
| Title : Evaluation of alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators using the parallel oocyte electrophysiology test station - Malysz_2009_Assay.Drug.Dev.Technol_7_374 |
| Author(s) : Malysz J , Gronlien JH , Timmermann DB , Hakerud M , Thorin-Hagene K , Ween H , Trumbull JD , Xiong Y , Briggs CA , Ahring PK , Dyhring T , Gopalakrishnan M |
| Ref : Assay Drug Dev Technol , 7 :374 , 2009 |
| Abstract : Malysz_2009_Assay.Drug.Dev.Technol_7_374 |
| ESTHER : Malysz_2009_Assay.Drug.Dev.Technol_7_374 |
| PubMedSearch : Malysz_2009_Assay.Drug.Dev.Technol_7_374 |
| PubMedID: 19689206 |
| Title : Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain - Marks_2009_Biochem.Pharmacol_78(7)_795 |
| Author(s) : Marks MJ , Wageman CR , Grady SR , Gopalakrishnan M , Briggs CA |
| Ref : Biochemical Pharmacology , 78 :795 , 2009 |
| Abstract : Marks_2009_Biochem.Pharmacol_78(7)_795 |
| ESTHER : Marks_2009_Biochem.Pharmacol_78(7)_795 |
| PubMedSearch : Marks_2009_Biochem.Pharmacol_78(7)_795 |
| PubMedID: 19481067 |
| Title : Poster: Radioligand binding characterization of [3H]-A-998679: A novel positive allosteric modulator of alpha4\/beta2 nAChRs - |
| Author(s) : Anderson DJ , Vaidyanathan S , Namovic M , Donnelly-Roberts D , Lee L , Gopalakrishnan M |
| Ref : Biochemical Pharmacology , 78 :903 , 2009 |
| PubMedID: |
| Title : Allosteric modulators of the alpha7 nicotinic acetylcholine receptor - |
| Author(s) : Faghih R , Gopalakrishnan M , Briggs CA |
| Ref : Journal of Medicinal Chemistry , 51 :701 , 2008 |
| PubMedID: 18198823 |
| Title : [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]hept ane], a novel high-affinity alpha7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain - Anderson_2008_J.Pharmacol.Exp.Ther_324_179 |
| Author(s) : Anderson DJ , Bunnelle W , Surber B , Du J , Surowy C , Tribollet E , Marguerat A , Bertrand D , Gopalakrishnan M |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 324 :179 , 2008 |
| Abstract : Anderson_2008_J.Pharmacol.Exp.Ther_324_179 |
| ESTHER : Anderson_2008_J.Pharmacol.Exp.Ther_324_179 |
| PubMedSearch : Anderson_2008_J.Pharmacol.Exp.Ther_324_179 |
| PubMedID: 17959745 |
| Title : Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells - Hu_2008_J.Neurochem_106_1371 |
| Author(s) : Hu M , Waring JF , Gopalakrishnan M , Li J |
| Ref : Journal of Neurochemistry , 106 :1371 , 2008 |
| Abstract : Hu_2008_J.Neurochem_106_1371 |
| ESTHER : Hu_2008_J.Neurochem_106_1371 |
| PubMedSearch : Hu_2008_J.Neurochem_106_1371 |
| PubMedID: 18485099 |
| Title : Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties - Tietje_2008_CNS.Neurosci.Ther_14_65 |
| Author(s) : Tietje KR , Anderson DJ , Bitner RS , Blomme EA , Brackemeyer PJ , Briggs CA , Browman KE , Bury D , Curzon P , Drescher KU , Frost JM , Fryer RM , Fox GB , Gronlien JH , Hakerud M , Gubbins EJ , Halm S , Harris R , Helfrich RJ , Kohlhaas KL , Law D , Malysz J , Marsh KC , Martin RL , Meyer MD , Molesky AL , Nikkel AL , Otte S , Pan L , Puttfarcken PS , Radek RJ , Robb HM , Spies E , Thorin-Hagene K , Waring JF , Ween H , Xu H , Gopalakrishnan M , Bunnelle WH |
| Ref : CNS Neurosci Ther , 14 :65 , 2008 |
| Abstract : Tietje_2008_CNS.Neurosci.Ther_14_65 |
| ESTHER : Tietje_2008_CNS.Neurosci.Ther_14_65 |
| PubMedSearch : Tietje_2008_CNS.Neurosci.Ther_14_65 |
| PubMedID: 18482100 |
| Title : Positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor: ligand interactions with distinct binding sites and evidence for a prominent role of the M2-M3 segment - Bertrand_2008_Mol.Pharmacol_74_1407 |
| Author(s) : Bertrand D , Bertrand S , Cassar S , Gubbins E , Li J , Gopalakrishnan M |
| Ref : Molecular Pharmacology , 74 :1407 , 2008 |
| Abstract : Bertrand_2008_Mol.Pharmacol_74_1407 |
| ESTHER : Bertrand_2008_Mol.Pharmacol_74_1407 |
| PubMedSearch : Bertrand_2008_Mol.Pharmacol_74_1407 |
| PubMedID: 18678621 |
| Title : Analysis of gene expression profiles in rat hippocampus following treatment with nicotine and an alpha7 nAChR selective agonist - Waring_2008_Neurosci.Res_60_266 |
| Author(s) : Waring JF , Abel S , Li J , Bitner RS , Nikkel AL , Blomme EA , Anderson DJ , Gopalakrishnan M |
| Ref : Neurosci Res , 60 :266 , 2008 |
| Abstract : Waring_2008_Neurosci.Res_60_266 |
| ESTHER : Waring_2008_Neurosci.Res_60_266 |
| PubMedSearch : Waring_2008_Neurosci.Res_60_266 |
| PubMedID: 18164502 |
| Title : alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues - Briggs_2008_Br.J.Pharmacol_153_1054 |
| Author(s) : Briggs CA , Schrimpf MR , Anderson DJ , Gubbins EJ , Gronlien JH , Hakerud M , Ween H , Thorin-Hagene K , Malysz J , Li J , Bunnelle WH , Gopalakrishnan M , Meyer MD |
| Ref : British Journal of Pharmacology , 153 :1054 , 2008 |
| Abstract : Briggs_2008_Br.J.Pharmacol_153_1054 |
| ESTHER : Briggs_2008_Br.J.Pharmacol_153_1054 |
| PubMedSearch : Briggs_2008_Br.J.Pharmacol_153_1054 |
| PubMedID: 18157163 |
| Title : The potential of neuronal nicotinic acetylcholine receptor agonists for treating CNS conditions - Decker_2008_Expert.Opin.Drug.Discov_3_1027 |
| Author(s) : Decker MW , Gopalakrishnan M , Meyer MD |
| Ref : Expert Opin Drug Discov , 3 :1027 , 2008 |
| Abstract : Decker_2008_Expert.Opin.Drug.Discov_3_1027 |
| ESTHER : Decker_2008_Expert.Opin.Drug.Discov_3_1027 |
| PubMedSearch : Decker_2008_Expert.Opin.Drug.Discov_3_1027 |
| PubMedID: 23506178 |
| Title : Advances in the discovery of novel positive allosteric modulators of the alpha7 nicotinic acetylcholine receptor - Faghih_2007_Recent.Pat.CNS.Drug.Discov_2_99 |
| Author(s) : Faghih R , Gfesser GA , Gopalakrishnan M |
| Ref : Recent Pat CNS Drug Discov , 2 :99 , 2007 |
| Abstract : Faghih_2007_Recent.Pat.CNS.Drug.Discov_2_99 |
| ESTHER : Faghih_2007_Recent.Pat.CNS.Drug.Discov_2_99 |
| PubMedSearch : Faghih_2007_Recent.Pat.CNS.Drug.Discov_2_99 |
| PubMedID: 18221220 |
| Title : Nicotinic acetylcholine receptors as therapeutic targets: emerging frontiers in basic research and clinical science - editorial comments - |
| Author(s) : Gopalakrishnan M , Bertrand D , Williams M |
| Ref : Biochemical Pharmacology , 74 :1091 , 2007 |
| PubMedID: 17889037 |
| Title : Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes - Gronlien_2007_Mol.Pharmacol_72_715 |
| Author(s) : Gronlien JH , Hakerud M , Ween H , Thorin-Hagene K , Briggs CA , Gopalakrishnan M , Malysz J |
| Ref : Molecular Pharmacology , 72 :715 , 2007 |
| Abstract : Gronlien_2007_Mol.Pharmacol_72_715 |
| ESTHER : Gronlien_2007_Mol.Pharmacol_72_715 |
| PubMedSearch : Gronlien_2007_Mol.Pharmacol_72_715 |
| PubMedID: 17565004 |
| Title : High content screen microscopy analysis of A beta 1-42-induced neurite outgrowth reduction in rat primary cortical neurons: neuroprotective effects of alpha 7 neuronal nicotinic acetylcholine receptor ligands - Hu_2007_Brain.Res_1151_227 |
| Author(s) : Hu M , Schurdak ME , Puttfarcken PS , El Kouhen R , Gopalakrishnan M , Li J |
| Ref : Brain Research , 1151 :227 , 2007 |
| Abstract : Hu_2007_Brain.Res_1151_227 |
| ESTHER : Hu_2007_Brain.Res_1151_227 |
| PubMedSearch : Hu_2007_Brain.Res_1151_227 |
| PubMedID: 17449017 |
| Title : An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo - Timmermann_2007_J.Pharmacol.Exp.Ther_323_294 |
| Author(s) : Timmermann DB , Gronlien JH , Kohlhaas KL , Nielsen EO , Dam E , Jorgensen TD , Ahring PK , Peters D , Holst D , Christensen JK , Malysz J , Briggs CA , Gopalakrishnan M , Olsen GM |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 323 :294 , 2007 |
| Abstract : Timmermann_2007_J.Pharmacol.Exp.Ther_323_294 |
| ESTHER : Timmermann_2007_J.Pharmacol.Exp.Ther_323_294 |
| PubMedSearch : Timmermann_2007_J.Pharmacol.Exp.Ther_323_294 |
| PubMedID: 17625074 |
| Title : Allosteric modulation of nicotinic acetylcholine receptors - Bertrand_2007_Biochem.Pharmacol_74(8)_1155 |
| Author(s) : Bertrand D , Gopalakrishnan M |
| Ref : Biochemical Pharmacology , 74 :1155 , 2007 |
| Abstract : Bertrand_2007_Biochem.Pharmacol_74(8)_1155 |
| ESTHER : Bertrand_2007_Biochem.Pharmacol_74(8)_1155 |
| PubMedSearch : Bertrand_2007_Biochem.Pharmacol_74(8)_1155 |
| PubMedID: 17707779 |
| Title : Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1\/2 and CREB phosphorylation pathways - Bitner_2007_J.Neurosci_27_10578 |
| Author(s) : Bitner RS , Bunnelle WH , Anderson DJ , Briggs CA , Buccafusco JJ , Curzon P , Decker MW , Frost JM , Gronlien JH , Gubbins E , Li J , Malysz J , Markosyan S , Marsh K , Meyer MD , Nikkel AL , Radek RJ , Robb HM , Timmermann DB , Sullivan JP , Gopalakrishnan M |
| Ref : Journal of Neuroscience , 27 :10578 , 2007 |
| Abstract : Bitner_2007_J.Neurosci_27_10578 |
| ESTHER : Bitner_2007_J.Neurosci_27_10578 |
| PubMedSearch : Bitner_2007_J.Neurosci_27_10578 |
| PubMedID: 17898229 |
| Title : Profile of nicotinic acetylcholine receptor agonists ABT-594 and A-582941, with differential subtype selectivity, on delayed matching accuracy by young monkeys - Buccafusco_2007_Biochem.Pharmacol_74(8)_1202 |
| Author(s) : Buccafusco JJ , Terry AV, Jr. , Decker MW , Gopalakrishnan M |
| Ref : Biochemical Pharmacology , 74 :1202 , 2007 |
| Abstract : Buccafusco_2007_Biochem.Pharmacol_74(8)_1202 |
| ESTHER : Buccafusco_2007_Biochem.Pharmacol_74(8)_1202 |
| PubMedSearch : Buccafusco_2007_Biochem.Pharmacol_74(8)_1202 |
| PubMedID: 17706609 |
| Title : Alpha4beta2 nicotinic receptor stimulation contributes to the effects of nicotine in the DBA\/2 mouse model of sensory gating - Radek_2006_Psychopharmacology.(Berl)_187_47 |
| Author(s) : Radek RJ , Miner HM , Bratcher NA , Decker MW , Gopalakrishnan M , Bitner RS |
| Ref : Psychopharmacology (Berl) , 187 :47 , 2006 |
| Abstract : Radek_2006_Psychopharmacology.(Berl)_187_47 |
| ESTHER : Radek_2006_Psychopharmacology.(Berl)_187_47 |
| PubMedSearch : Radek_2006_Psychopharmacology.(Berl)_187_47 |
| PubMedID: 16767415 |
| Title : Antisense knockdown of the rat alpha7 nicotinic acetylcholine receptor produces spatial memory impairment - Curzon_2006_Neurosci.Lett_410_15 |
| Author(s) : Curzon P , Anderson DJ , Nikkel AL , Fox GB , Gopalakrishnan M , Decker MW , Bitner RS |
| Ref : Neuroscience Letters , 410 :15 , 2006 |
| Abstract : Curzon_2006_Neurosci.Lett_410_15 |
| ESTHER : Curzon_2006_Neurosci.Lett_410_15 |
| PubMedSearch : Curzon_2006_Neurosci.Lett_410_15 |
| PubMedID: 17055644 |
| Title : ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders - Rueter_2004_CNS.Drug.Rev_10_167 |
| Author(s) : Rueter LE , Anderson DJ , Briggs CA , Donnelly-Roberts D , Gintant GA , Gopalakrishnan M , Lin NH , Osinski MA , Reinhart GA , Buckley MJ , Martin RL , McDermott JS , Preusser LC , Seifert TR , Su Z , Cox BF , Decker MW , Sullivan JP |
| Ref : CNS Drug Rev , 10 :167 , 2004 |
| Abstract : Rueter_2004_CNS.Drug.Rev_10_167 |
| ESTHER : Rueter_2004_CNS.Drug.Rev_10_167 |
| PubMedSearch : Rueter_2004_CNS.Drug.Rev_10_167 |
| PubMedID: 15179445 |
| Title : Neuronal nicotinic receptors: filling the void? - |
| Author(s) : Gopalakrishnan M , Bitner RS |
| Ref : American Journal of Physiology Regul Integr Comp Physiol , 285 :R21 , 2003 |
| PubMedID: 12793987 |
| Title : Gain of function mutation of the alpha7 nicotinic receptor: distinct pharmacology of the human alpha7V274T variant - Briggs_1999_Eur.J.Pharmacol_366_301 |
| Author(s) : Briggs CA , McKenna DG , Monteggia LM , Touma E , Roch JM , Arneric SP , Gopalakrishnan M , Sullivan JP |
| Ref : European Journal of Pharmacology , 366 :301 , 1999 |
| Abstract : Briggs_1999_Eur.J.Pharmacol_366_301 |
| ESTHER : Briggs_1999_Eur.J.Pharmacol_366_301 |
| PubMedSearch : Briggs_1999_Eur.J.Pharmacol_366_301 |
| PubMedID: 10082212 |
| Title : Up-regulation of human alpha7 nicotinic receptors by chronic treatment with activator and antagonist ligands - Molinari_1998_Eur.J.Pharmacol_347_131 |
| Author(s) : Molinari EJ , Delbono O , Messi ML , Renganathan M , Arneric SP , Sullivan JP , Gopalakrishnan M |
| Ref : European Journal of Pharmacology , 347 :131 , 1998 |
| Abstract : Molinari_1998_Eur.J.Pharmacol_347_131 |
| ESTHER : Molinari_1998_Eur.J.Pharmacol_347_131 |
| PubMedSearch : Molinari_1998_Eur.J.Pharmacol_347_131 |
| PubMedID: 9650859 |
| Title : Regulation of human alpha4beta2 neuronal nicotinic acetylcholine receptors by cholinergic channel ligands and second messenger pathways - Gopalakrishnan_1997_Mol.Pharmacol_52_524 |
| Author(s) : Gopalakrishnan M , Molinari EJ , Sullivan JP |
| Ref : Molecular Pharmacology , 52 :524 , 1997 |
| Abstract : Gopalakrishnan_1997_Mol.Pharmacol_52_524 |
| ESTHER : Gopalakrishnan_1997_Mol.Pharmacol_52_524 |
| PubMedSearch : Gopalakrishnan_1997_Mol.Pharmacol_52_524 |
| PubMedID: 9281615 |
| Title : ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties - Sullivan_1997_J.Pharmacol.Exp.Ther_283_235 |
| Author(s) : Sullivan JP , Donnelly-Roberts D , Briggs CA , Anderson DJ , Gopalakrishnan M , Xue IC , Piattoni-Kaplan M , Molinari E , Campbell JE , McKenna DG , Gunn DE , Lin NH , Ryther KB , He Y , Holladay MW , Wonnacott S , Williams M , Arneric SP |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 283 :235 , 1997 |
| Abstract : Sullivan_1997_J.Pharmacol.Exp.Ther_283_235 |
| ESTHER : Sullivan_1997_J.Pharmacol.Exp.Ther_283_235 |
| PubMedSearch : Sullivan_1997_J.Pharmacol.Exp.Ther_283_235 |
| PubMedID: 9336329 |
| Title : Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo - Briggs_1997_Pharmacol.Biochem.Behav_57_231 |
| Author(s) : Briggs CA , Anderson DJ , Brioni JD , Buccafusco JJ , Buckley MJ , Campbell JE , Decker MW , Donnelly-Roberts D , Elliott RL , Gopalakrishnan M , Holladay MW , Hui YH , Jackson WJ , Kim DJ , Marsh KC , O'Neill A , Prendergast MA , Ryther KB , Sullivan JP , Arneric SP |
| Ref : Pharmacol Biochem Behav , 57 :231 , 1997 |
| Abstract : Briggs_1997_Pharmacol.Biochem.Behav_57_231 |
| ESTHER : Briggs_1997_Pharmacol.Biochem.Behav_57_231 |
| PubMedSearch : Briggs_1997_Pharmacol.Biochem.Behav_57_231 |
| PubMedID: 9164577 |
| Title : Activation of the recombinant human alpha 7 nicotinic acetylcholine receptor significantly raises intracellular free calcium - Delbono_1997_J.Pharmacol.Exp.Ther_280_428 |
| Author(s) : Delbono O , Gopalakrishnan M , Renganathan M , Monteggia LM , Messi ML , Sullivan JP |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 280 :428 , 1997 |
| Abstract : Delbono_1997_J.Pharmacol.Exp.Ther_280_428 |
| ESTHER : Delbono_1997_J.Pharmacol.Exp.Ther_280_428 |
| PubMedSearch : Delbono_1997_J.Pharmacol.Exp.Ther_280_428 |
| PubMedID: 8996225 |
| Title : Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor - Gopalakrishnan_1996_J.Pharmacol.Exp.Ther_276_289 |
| Author(s) : Gopalakrishnan M , Monteggia LM , Anderson DJ , Molinari EJ , Piattoni-Kaplan M , Donnelly-Roberts D , Arneric SP , Sullivan JP |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 276 :289 , 1996 |
| Abstract : Gopalakrishnan_1996_J.Pharmacol.Exp.Ther_276_289 |
| ESTHER : Gopalakrishnan_1996_J.Pharmacol.Exp.Ther_276_289 |
| PubMedSearch : Gopalakrishnan_1996_J.Pharmacol.Exp.Ther_276_289 |
| PubMedID: 8558445 |
| Title : A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand - Sullivan_1996_Neuropharmacol_35_725 |
| Author(s) : Sullivan JP , Donnelly-Roberts D , Briggs CA , Anderson DJ , Gopalakrishnan M , Piattoni-Kaplan M , Campbell JE , McKenna DG , Molinari E , Hettinger AM , Garvey DS , Wasicak JT , Holladay MW , Williams M , Arneric SP |
| Ref : Neuropharmacology , 35 :725 , 1996 |
| Abstract : Sullivan_1996_Neuropharmacol_35_725 |
| ESTHER : Sullivan_1996_Neuropharmacol_35_725 |
| PubMedSearch : Sullivan_1996_Neuropharmacol_35_725 |
| PubMedID: 8887981 |
| Title : Human alpha4beta2 neuronal nicotinic acetylcholine receptor in HEK 293 cells: A patch-clamp study - Buisson_1996_J.Neurosci_16_7880 |
| Author(s) : Buisson B , Gopalakrishnan M , Arneric SP , Sullivan JP , Bertrand D |
| Ref : Journal of Neuroscience , 16 :7880 , 1996 |
| Abstract : Buisson_1996_J.Neurosci_16_7880 |
| ESTHER : Buisson_1996_J.Neurosci_16_7880 |
| PubMedSearch : Buisson_1996_J.Neurosci_16_7880 |
| PubMedID: 8987816 |
| Title : Stable expression and pharmacological properties of the human alpha 7 nicotinic acetylcholine receptor - Gopalakrishnan_1995_Eur.J.Pharmacol_290_237 |
| Author(s) : Gopalakrishnan M , Buisson B , Touma E , Giordano T , Campbell JE , Hu IC , Donnelly-Roberts D , Arneric SP , Bertrand D , Sullivan JP |
| Ref : European Journal of Pharmacology , 290 :237 , 1995 |
| Abstract : Gopalakrishnan_1995_Eur.J.Pharmacol_290_237 |
| ESTHER : Gopalakrishnan_1995_Eur.J.Pharmacol_290_237 |
| PubMedSearch : Gopalakrishnan_1995_Eur.J.Pharmacol_290_237 |
| PubMedID: 7589218 |
| Title : Cloning and transient expression of genes encoding the human alpha 4 and beta 2 neuronal nicotinic acetylcholine receptor (nAChR) subunits - Monteggia_1995_Gene_155_189 |
| Author(s) : Monteggia LM , Gopalakrishnan M , Touma E , Idler KB , Nash N , Arneric SP , Sullivan JP , Giordano T |
| Ref : Gene , 155 :189 , 1995 |
| Abstract : Monteggia_1995_Gene_155_189 |
| ESTHER : Monteggia_1995_Gene_155_189 |
| PubMedSearch : Monteggia_1995_Gene_155_189 |
| PubMedID: 7721089 |