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Author Report for: Hepnarova V

Contact information:

Hepnarova Vendula
Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01; Biomedical Research Centre, University Hospital, Sokolska 581, 500 05, Hradec Kralove
Czech Republic
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    Title: Non-covalent acetylcholinesterase inhibitors: In vitro screening and molecular modeling for novel selective insecticides
    Hepnarova V, Hrabinova M, Muckova L, Kucera T, Schmidt M, Dolezal R, Gorecki L, Hrabcova V, Korabecny J and Pejchal J <2 more author(s)>
    Ref: Toxicol In Vitro, :105463, 2022 : PubMed


    Title: Toxicity, pharmacokinetics, and effectiveness of the ortho-chlorinated bispyridinium oxime, K870
    Karasova JZ, Kassa J, Hepnarova V, Pejchal J, Junova L, Andrys R, Malinak D, Bzonek P, Kohoutova Z, Musilek K
    Ref: Food & Chemical Toxicology, :113236, 2022 : PubMed


    Title: Development of versatile and potent monoquaternary reactivators of acetylcholinesterase
    Gorecki L, Hepnarova V, Karasova JZ, Hrabinova M, Courageux C, Dias J, Kucera T, Kobrlova T, Muckova L and Korabecny J <7 more author(s)>
    Ref: Archives of Toxicology, :, 2021 : PubMed


    Title: Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease
    Gorecki L, Uliassi E, Bartolini M, Janockova J, Hrabinova M, Hepnarova V, Prchal L, Muckova L, Pejchal J and Bolognesi ML <8 more author(s)>
    Ref: ACS Chem Neurosci, :, 2021 : PubMed


    Title: Design and synthesis of novel tacrine-indole hybrids as potential multitarget-directed ligands for the treatment of Alzheimer's disease
    Hamulakova S, Kudlickova Z, Janovec L, Mezencev R, Deckner ZJ, Chernoff YO, Janockova J, Ihnatova V, Bzonek P and Kuca K <6 more author(s)>
    Ref: Future Med Chem, :, 2021 : PubMed


    Title: (+/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease
    Ismaili L, Monnin J, Etievant A, Arribas RL, Viejo L, Refouvelet B, Soukup O, Janockova J, Hepnarova V and Haffen E <12 more author(s)>
    Ref: ACS Chem Neurosci, :, 2021 : PubMed


    Title: 7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo
    Kaniakova M, Korabecny J, Holubova K, Kleteckova L, Chvojkova M, Hakenova K, Prchal L, Novak M, Dolezal R and Soukup O <7 more author(s)>
    Ref: Biochemical Pharmacology, :114460, 2021 : PubMed


    Title: A Comparison of the Neuroprotective and Reactivating Efficacy of a Novel Bispyridinium Oxime K870 with Commonly Used Pralidoxime and the Oxime HI-6 in Tabun-Poisoned Rats
    Kassa J, Hatlapatkova J, arova Karasova J, Hepnarova V, Caisberger F, Pejchal J
    Ref: Acta Medica (Hradec Kralove), 64:145, 2021 : PubMed


    Title: Huprine Y - tryptophan heterodimers with potential implication to Alzheimer's disease treatment
    Mezeiova E, Hrabinova M, Hepnarova V, Jun D, Janockova J, Muckova L, Prchal L, Kristofikova Z, Kucera T and Korabecny J <5 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, :128100, 2021 : PubMed


    Title: Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors
    Gorecki L, Andrys R, Schmidt M, Kucera T, Psotka M, Svobodova B, Hrabcova V, Hepnarova V, Bzonek P and Musilek K <3 more author(s)>
    Ref: ACS Med Chem Lett, 11:65, 2020 : PubMed


    Title: Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators
    Malinak D, Dolezal R, Hepnarova V, Hozova M, Andrys R, Bzonek P, Racakova V, Korabecny J, Gorecki L and Musilek K <4 more author(s)>
    Ref: J Enzyme Inhib Med Chem, 35:478, 2020 : PubMed


    Title: Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimes drugs dealing with cholinergic, amyloid and mitochondrial systems
    Nepovimova E, Svobodova L, Dolezal R, Hepnarova V, Junova L, Jun D, Korabecny J, Kucera T, Gazova Z and Kuca K <20 more author(s)>
    Ref: Bioorg Chem, 107:104596, 2020 : PubMed


    Title: Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile
    Sobolova K, Hrabinova M, Hepnarova V, Kucera T, Kobrlova T, Benkova M, Janockova J, Dolezal R, Prchal L and Korabecny J <4 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 203:112593, 2020 : PubMed


    Title: Encapsulation of oxime K027 into cucurbit[7]uril: In vivo evaluation of safety, absorption, brain distribution and reactivation effectiveness
    Zdarova Karasova J, Hepnarova V, Andrys R, Lisa M, Jost P, Muckova L, Pejchal J, Herman D, Jun D and Kuca K <1 more author(s)>
    Ref: Toxicol Lett, 320:64, 2020 : PubMed


    Title: Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
    Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ and Kuca K <25 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 168:491, 2019 : PubMed


    Title: Tacroximes: novel unique compounds for the recovery of organophosphorus-inhibited acetylcholinesterase
    Gorecki L, Junova L, Kucera T, Hepnarova V, Prchal L, Kobrlova T, Muckova L, Soukup O, Korabecny J
    Ref: Future Med Chem, 11:2625, 2019 : PubMed


    Title: Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators
    Hepnarova V, Muckova L, Ring A, Pejchal J, Herman D, Misik J, Hrabinova M, Jun D, Soukup O
    Ref: Toxicol Appl Pharmacol, :114776, 2019 : PubMed


    Title: Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease
    Kaniakova M, Nepovimova E, Kleteckova L, Skrenkova K, Holubova K, Chrienova Z, Hepnarova V, Kucera T, Kobrlova T and Horak M <3 more author(s)>
    Ref: Curr Alzheimer Res, 16:821, 2019 : PubMed


    Title: N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer's Disease Therapy
    Nepovimova E, Korabecny J, Hepnarova V, Jun D, Dolezal R, Muckova L, Jost P, Soukup O, Janockova J and Kuca K <3 more author(s)>
    Ref: Curr Alzheimer Res, 16:333, 2019 : PubMed


    Title: Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors
    Svobodova B, Mezeiova E, Hepnarova V, Hrabinova M, Muckova L, Kobrlova T, Jun D, Soukup O, Jimeno ML and Korabecny J <1 more author(s)>
    Ref: Biomolecules, 9:, 2019 : PubMed


    Title: Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats
    Zdarova Karasova J, Soukup O, Korabecny J, Hroch M, Krejciova M, Hrabinova M, Misik J, Novotny L, Hepnarova V, Kuca K
    Ref: Drug & Chemical Toxicology, :1, 2019 : PubMed


    Title: The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease
    Hepnarova V, Korabecny J, Matouskova L, Jost P, Muckova L, Hrabinova M, Vykoukalova N, Kerhartova M, Kucera T and Soukup O <9 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 150:292, 2018 : PubMed


    Title: Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods
    Janockova J, Dolezal R, Nepovimova E, Kobrlova T, Benkova M, Kuca K, Konecny J, Mezeiova E, Melikova M and Korabecny J <3 more author(s)>
    Ref: Molecules, 23:, 2018 : PubMed


    Title: In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?
    Soukup O, Korabecny J, Malinak D, Nepovimova E, Pham NL, Musilek K, Hrabinova M, Hepnarova V, Dolezal R and Kuca K <12 more author(s)>
    Ref: Med Chem, 14:281, 2018 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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