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Title : A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence - Jiang_2023_Nat.Commun_14_8039 |
Author(s) : Jiang M , Huizenga MCW , Wirt JL , Paloczi J , Amedi A , van den Berg R , Benz J , Collin L , Deng H , Di X , Driever WF , Florea BI , Grether U , Janssen APA , Hankemeier T , Heitman LH , Lam TW , Mohr F , Pavlovic A , Ruf I , van den Hurk H , Stevens AF , van der Vliet D , van der Wel T , Wittwer MB , van Boeckel CAA , Pacher P , Hohmann AG , van der Stelt M |
Ref : Nat Commun , 14 :8039 , 2023 |
Abstract : Jiang_2023_Nat.Commun_14_8039 |
ESTHER : Jiang_2023_Nat.Commun_14_8039 |
PubMedSearch : Jiang_2023_Nat.Commun_14_8039 |
PubMedID: 38052772 |
Title : ( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes - Liu_2018_J.Med.Chem_61_8639 |
Author(s) : Liu Y , Ji L , Eno M , Kudalkar S , Li AL , Schimpgen M , Benchama O , Morales P , Xu S , Hurst D , Wu S , Mohammad KA , Wood JT , Zvonok N , Papahatjis DP , Zhou H , Honrao C , Mackie K , Reggio P , Hohmann AG , Marnett LJ , Makriyannis A , Nikas SP |
Ref : Journal of Medicinal Chemistry , 61 :8639 , 2018 |
Abstract : Liu_2018_J.Med.Chem_61_8639 |
ESTHER : Liu_2018_J.Med.Chem_61_8639 |
PubMedSearch : Liu_2018_J.Med.Chem_61_8639 |
PubMedID: 30196704 |
Title : Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment - Guindon_2013_Pharmacol.Res_67_94 |
Author(s) : Guindon J , Lai Y , Takacs SM , Bradshaw HB , Hohmann AG |
Ref : Pharmacol Res , 67 :94 , 2013 |
Abstract : Guindon_2013_Pharmacol.Res_67_94 |
ESTHER : Guindon_2013_Pharmacol.Res_67_94 |
PubMedSearch : Guindon_2013_Pharmacol.Res_67_94 |
PubMedID: 23127915 |
Title : Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-alpha initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia - Gregg_2012_J.Neurosci_32_9457 |
Author(s) : Gregg LC , Jung KM , Spradley JM , Nyilas R , Suplita RL, 2nd , Zimmer A , Watanabe M , Mackie K , Katona I , Piomelli D , Hohmann AG |
Ref : Journal of Neuroscience , 32 :9457 , 2012 |
Abstract : Gregg_2012_J.Neurosci_32_9457 |
ESTHER : Gregg_2012_J.Neurosci_32_9457 |
PubMedSearch : Gregg_2012_J.Neurosci_32_9457 |
PubMedID: 22787031 |
Gene_locus related to this paper: human-DAGLA |
Title : Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats - Sciolino_2011_Pharmacol.Res_64_226 |
Author(s) : Sciolino NR , Zhou W , Hohmann AG |
Ref : Pharmacol Res , 64 :226 , 2011 |
Abstract : Sciolino_2011_Pharmacol.Res_64_226 |
ESTHER : Sciolino_2011_Pharmacol.Res_64_226 |
PubMedSearch : Sciolino_2011_Pharmacol.Res_64_226 |
PubMedID: 21600985 |
Title : Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain - Guindon_2011_Br.J.Pharmacol_163_1464 |
Author(s) : Guindon J , Guijarro A , Piomelli D , Hohmann AG |
Ref : British Journal of Pharmacology , 163 :1464 , 2011 |
Abstract : Guindon_2011_Br.J.Pharmacol_163_1464 |
ESTHER : Guindon_2011_Br.J.Pharmacol_163_1464 |
PubMedSearch : Guindon_2011_Br.J.Pharmacol_163_1464 |
PubMedID: 21198549 |
Title : Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms - Spradley_2010_Pharmacol.Res_62_249 |
Author(s) : Spradley JM , Guindon J , Hohmann AG |
Ref : Pharmacol Res , 62 :249 , 2010 |
Abstract : Spradley_2010_Pharmacol.Res_62_249 |
ESTHER : Spradley_2010_Pharmacol.Res_62_249 |
PubMedSearch : Spradley_2010_Pharmacol.Res_62_249 |
PubMedID: 20416378 |
Title : A physiological role for endocannabinoid-derived products of cyclooxygenase-2-mediated oxidative metabolism - Guindon_2008_Br.J.Pharmacol_153_1341 |
Author(s) : Guindon J , Hohmann AG |
Ref : British Journal of Pharmacology , 153 :1341 , 2008 |
Abstract : Guindon_2008_Br.J.Pharmacol_153_1341 |
ESTHER : Guindon_2008_Br.J.Pharmacol_153_1341 |
PubMedSearch : Guindon_2008_Br.J.Pharmacol_153_1341 |
PubMedID: 18297102 |
Title : Inhibitors of monoacylglycerol lipase as novel analgesics - Hohmann_2007_Br.J.Pharmacol_150_673 |
Author(s) : Hohmann AG |
Ref : British Journal of Pharmacology , 150 :673 , 2007 |
Abstract : Hohmann_2007_Br.J.Pharmacol_150_673 |
ESTHER : Hohmann_2007_Br.J.Pharmacol_150_673 |
PubMedSearch : Hohmann_2007_Br.J.Pharmacol_150_673 |
PubMedID: 17293886 |