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| Title : alpha4beta2 neuronal nicotinic receptor positive allosteric modulation: an approach for improving the therapeutic index of alpha4beta2 nAChR agonists in pain - Lee_2011_Biochem.Pharmacol_82(8)_959 |
| Author(s) : Lee CH , Zhu C , Malysz J , Campbell T , Shaughnessy T , Honore P , Polakowski J , Gopalakrishnan M |
| Ref : Biochemical Pharmacology , 82 :959 , 2011 |
| Abstract : Lee_2011_Biochem.Pharmacol_82(8)_959 |
| ESTHER : Lee_2011_Biochem.Pharmacol_82(8)_959 |
| PubMedSearch : Lee_2011_Biochem.Pharmacol_82(8)_959 |
| PubMedID: 21763685 |
| Title : Potentiation of analgesic efficacy but not side effects: co-administration of an alpha4beta2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats - Zhu_2011_Biochem.Pharmacol_82(8)_967 |
| Author(s) : Zhu CZ , Chin CL , Rustay NR , Zhong C , Mikusa J , Chandran P , Salyers A , Gomez E , Simler G , Lewis LG , Gauvin D , Baker S , Pai M , Tovcimak A , Brown J , Komater V , Fox GB , Decker MW , Jacobson PB , Gopalakrishnan M , Lee CH , Honore P |
| Ref : Biochemical Pharmacology , 82 :967 , 2011 |
| Abstract : Zhu_2011_Biochem.Pharmacol_82(8)_967 |
| ESTHER : Zhu_2011_Biochem.Pharmacol_82(8)_967 |
| PubMedSearch : Zhu_2011_Biochem.Pharmacol_82(8)_967 |
| PubMedID: 21620806 |
| Title : Poster: Improving the efficacy-tolerability profile of nAChR agonists for the treatment of neuropathic pain in combination with positive allosteric modulators - |
| Author(s) : Lee C-H , Zhu C , Campbell T , Shaughnessy T , Honore P , Polakowski J , Gopalakrishnan M |
| Ref : Biochemical Pharmacology , 78 :920 , 2009 |
| PubMedID: |
| Title : The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1alphabeta knockout mice - Honore_2009_Behav.Brain.Res_204_77 |
| Author(s) : Honore P , Donnelly-Roberts D , Namovic M , Zhong C , Wade C , Chandran P , Zhu C , Carroll W , Perez-Medrano A , Iwakura Y , Jarvis MF |
| Ref : Behavioural Brain Research , 204 :77 , 2009 |
| Abstract : Honore_2009_Behav.Brain.Res_204_77 |
| ESTHER : Honore_2009_Behav.Brain.Res_204_77 |
| PubMedSearch : Honore_2009_Behav.Brain.Res_204_77 |
| PubMedID: 19464323 |
| Title : Poster: In vivo characterization of the co-administration of alpha4\/beta2 neuronal nicotinic receptor agonist and positive allosteric modulator in experimental pain in rats - |
| Author(s) : Zhu CZ , Chin C-l , Zhong C , Mikusa J , Chandran P , Salyers A , Wensink E , Silmer G , Lewis LG , Gauvin D , Baker S , Tovcimak A , Brown J , Rustay N , Fox GB , Decker MW , Lee C-H , Gopalakrishnan M , Honore P |
| Ref : Biochemical Pharmacology , 78 :920 , 2009 |
| PubMedID: |
| Title : Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain - Perez-Medrano_2009_J.Med.Chem_52_3366 |
| Author(s) : Perez-Medrano A , Donnelly-Roberts D , Honore P , Hsieh GC , Namovic MT , Peddi S , Shuai Q , Wang Y , Faltynek CR , Jarvis MF , Carroll WA |
| Ref : Journal of Medicinal Chemistry , 52 :3366 , 2009 |
| Abstract : Perez-Medrano_2009_J.Med.Chem_52_3366 |
| ESTHER : Perez-Medrano_2009_J.Med.Chem_52_3366 |
| PubMedSearch : Perez-Medrano_2009_J.Med.Chem_52_3366 |
| PubMedID: 19397270 |
| Title : Painful purinergic receptors - Donnelly-Roberts_2008_J.Pharmacol.Exp.Ther_324_409 |
| Author(s) : Donnelly-Roberts D , McGaraughty S , Shieh CC , Honore P , Jarvis MF |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 324 :409 , 2008 |
| Abstract : Donnelly-Roberts_2008_J.Pharmacol.Exp.Ther_324_409 |
| ESTHER : Donnelly-Roberts_2008_J.Pharmacol.Exp.Ther_324_409 |
| PubMedSearch : Donnelly-Roberts_2008_J.Pharmacol.Exp.Ther_324_409 |
| PubMedID: 18042830 |
| Title : Structure-activity relationship studies on N'-aryl carbohydrazide P2X7 antagonists - Nelson_2008_J.Med.Chem_51_3030 |
| Author(s) : Nelson DW , Sarris K , Kalvin DM , Namovic MT , Grayson G , Donnelly-Roberts D , Harris R , Honore P , Jarvis MF , Faltynek CR , Carroll WA |
| Ref : Journal of Medicinal Chemistry , 51 :3030 , 2008 |
| Abstract : Nelson_2008_J.Med.Chem_51_3030 |
| ESTHER : Nelson_2008_J.Med.Chem_51_3030 |
| PubMedSearch : Nelson_2008_J.Med.Chem_51_3030 |
| PubMedID: 18438986 |
| Title : Novel and potent 3-(2,3-dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 antagonists - Carroll_2007_Bioorg.Med.Chem.Lett_17_4044 |
| Author(s) : Carroll WA , Kalvin DM , Perez Medrano A , Florjancic AS , Wang Y , Donnelly-Roberts D , Namovic MT , Grayson G , Honore P , Jarvis MF |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :4044 , 2007 |
| Abstract : Carroll_2007_Bioorg.Med.Chem.Lett_17_4044 |
| ESTHER : Carroll_2007_Bioorg.Med.Chem.Lett_17_4044 |
| PubMedSearch : Carroll_2007_Bioorg.Med.Chem.Lett_17_4044 |
| PubMedID: 17482819 |
| Title : P2X7-related modulation of pathological nociception in rats - McGaraughty_2007_Neurosci_146_1817 |
| Author(s) : McGaraughty S , Chu KL , Namovic MT , Donnelly-Roberts D , Harris RR , Zhang XF , Shieh CC , Wismer CT , Zhu CZ , Gauvin DM , Fabiyi AC , Honore P , Gregg RJ , Kort ME , Nelson DW , Carroll WA , Marsh K , Faltynek CR , Jarvis MF |
| Ref : Neuroscience , 146 :1817 , 2007 |
| Abstract : McGaraughty_2007_Neurosci_146_1817 |
| ESTHER : McGaraughty_2007_Neurosci_146_1817 |
| PubMedSearch : McGaraughty_2007_Neurosci_146_1817 |
| PubMedID: 17478048 |
| Title : A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat - Honore_2006_J.Pharmacol.Exp.Ther_319_1376 |
| Author(s) : Honore P , Donnelly-Roberts D , Namovic MT , Hsieh G , Zhu CZ , Mikusa JP , Hernandez G , Zhong C , Gauvin DM , Chandran P , Harris R , Medrano AP , Carroll W , Marsh K , Sullivan JP , Faltynek CR , Jarvis MF |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 319 :1376 , 2006 |
| Abstract : Honore_2006_J.Pharmacol.Exp.Ther_319_1376 |
| ESTHER : Honore_2006_J.Pharmacol.Exp.Ther_319_1376 |
| PubMedSearch : Honore_2006_J.Pharmacol.Exp.Ther_319_1376 |
| PubMedID: 16982702 |
| Title : Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists - Nelson_2006_J.Med.Chem_49_3659 |
| Author(s) : Nelson DW , Gregg RJ , Kort ME , Perez-Medrano A , Voight EA , Wang Y , Grayson G , Namovic MT , Donnelly-Roberts D , Niforatos W , Honore P , Jarvis MF , Faltynek CR , Carroll WA |
| Ref : Journal of Medicinal Chemistry , 49 :3659 , 2006 |
| Abstract : Nelson_2006_J.Med.Chem_49_3659 |
| ESTHER : Nelson_2006_J.Med.Chem_49_3659 |
| PubMedSearch : Nelson_2006_J.Med.Chem_49_3659 |
| PubMedID: 16759108 |