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Title : Design of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit - Willis_2022_J.Med.Chem_65_7212 |
Author(s) : Willis NJ , Mahy W , Sipthorp J , Zhao Y , Woodward HL , Atkinson BN , Bayle ED , Svensson F , Frew S , Jeganathan F , Monaghan A , Benvegnu S , Jolly S , Vecchia L , Ruza RR , Kjaer S , Howell SA , Snidjers AP , Bictash M , Salinas PC , Vincent JP , Jones EY , Whiting P , Fish PV |
Ref : Journal of Medicinal Chemistry , 65 :7212 , 2022 |
Abstract : Willis_2022_J.Med.Chem_65_7212 |
ESTHER : Willis_2022_J.Med.Chem_65_7212 |
PubMedSearch : Willis_2022_J.Med.Chem_65_7212 |
PubMedID: 35536179 |
Gene_locus related to this paper: human-NOTUM |
Title : Notum deacylates Wnt proteins to suppress signalling activity - Kakugawa_2015_Nature_519_187 |
Author(s) : Kakugawa S , Langton PF , Zebisch M , Howell SA , Chang TH , Liu Y , Feizi T , Bineva G , O'Reilly N , Snijders AP , Jones EY , Vincent JP |
Ref : Nature , 519 :187 , 2015 |
Abstract : Kakugawa_2015_Nature_519_187 |
ESTHER : Kakugawa_2015_Nature_519_187 |
PubMedSearch : Kakugawa_2015_Nature_519_187 |
PubMedID: 25731175 |
Gene_locus related to this paper: drome-q9vux3 , human-NOTUM |