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| Title : Selective Inhibitors of Human Liver Carboxylesterase Based on a beta-Lapachone Scaffold: Novel Reagents for Reaction Profiling - Hatfield_2017_J.Med.Chem_60_1568 |
| Author(s) : Hatfield MJ , Chen J , Fratt EM , Chi L , Bollinger JC , Binder RJ , Bowling J , Hyatt JL , Scarborough J , Jeffries C , Potter PM |
| Ref : Journal of Medicinal Chemistry , 60 :1568 , 2017 |
| Abstract : Hatfield_2017_J.Med.Chem_60_1568 |
| ESTHER : Hatfield_2017_J.Med.Chem_60_1568 |
| PubMedSearch : Hatfield_2017_J.Med.Chem_60_1568 |
| PubMedID: 28112927 |
| Title : Carboxylesterases: General detoxifying enzymes - Hatfield_2016_Chem.Biol.Interact_259_327 |
| Author(s) : Hatfield MJ , Umans RA , Hyatt JL , Edwards CC , Wierdl M , Tsurkan L , Taylor MR , Potter PM |
| Ref : Chemico-Biological Interactions , 259 :327 , 2016 |
| Abstract : Hatfield_2016_Chem.Biol.Interact_259_327 |
| ESTHER : Hatfield_2016_Chem.Biol.Interact_259_327 |
| PubMedSearch : Hatfield_2016_Chem.Biol.Interact_259_327 |
| PubMedID: 26892220 |
| Title : Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors - Tsurkan_2013_Chem.Biol.Interact_203_226 |
| Author(s) : Tsurkan LG , Hatfield MJ , Edwards CC , Hyatt JL , Potter PM |
| Ref : Chemico-Biological Interactions , 203 :226 , 2013 |
| Abstract : Tsurkan_2013_Chem.Biol.Interact_203_226 |
| ESTHER : Tsurkan_2013_Chem.Biol.Interact_203_226 |
| PubMedSearch : Tsurkan_2013_Chem.Biol.Interact_203_226 |
| PubMedID: 23123248 |
| Title : Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza (Danshen) - Hatfield_2013_J.Nat.Prod_76_36 |
| Author(s) : Hatfield MJ , Tsurkan LG , Hyatt JL , Edwards CC , Lemoff A , Jeffries C , Yan B , Potter PM |
| Ref : Journal of Natural Products , 76 :36 , 2013 |
| Abstract : Hatfield_2013_J.Nat.Prod_76_36 |
| ESTHER : Hatfield_2013_J.Nat.Prod_76_36 |
| PubMedSearch : Hatfield_2013_J.Nat.Prod_76_36 |
| PubMedID: 23286284 |
| Title : Organ-specific carboxylesterase profiling identifies the small intestine and kidney as major contributors of activation of the anticancer prodrug CPT-11 - Hatfield_2011_Biochem.Pharmacol_81_24 |
| Author(s) : Hatfield MJ , Tsurkan L , Garrett M , Shaver TM , Hyatt JL , Edwards CC , Hicks LD , Potter PM |
| Ref : Biochemical Pharmacology , 81 :24 , 2011 |
| Abstract : Hatfield_2011_Biochem.Pharmacol_81_24 |
| ESTHER : Hatfield_2011_Biochem.Pharmacol_81_24 |
| PubMedSearch : Hatfield_2011_Biochem.Pharmacol_81_24 |
| PubMedID: 20833148 |
| Title : Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones - Parkinson_2011_Bioorg.Med.Chem_19_4635 |
| Author(s) : Parkinson EI , Hatfield MJ , Tsurkan L , Hyatt JL , Edwards CC , Hicks LD , Yan B , Potter PM |
| Ref : Bioorganic & Medicinal Chemistry , 19 :4635 , 2011 |
| Abstract : Parkinson_2011_Bioorg.Med.Chem_19_4635 |
| ESTHER : Parkinson_2011_Bioorg.Med.Chem_19_4635 |
| PubMedSearch : Parkinson_2011_Bioorg.Med.Chem_19_4635 |
| PubMedID: 21733699 |
| Title : Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin - Hatfield_2010_Br.J.Pharmacol_160_1916 |
| Author(s) : Hatfield MJ , Tsurkan LG , Hyatt JL , Yu X , Edwards CC , Hicks LD , Wadkins RM , Potter PM |
| Ref : British Journal of Pharmacology , 160 :1916 , 2010 |
| Abstract : Hatfield_2010_Br.J.Pharmacol_160_1916 |
| ESTHER : Hatfield_2010_Br.J.Pharmacol_160_1916 |
| PubMedSearch : Hatfield_2010_Br.J.Pharmacol_160_1916 |
| PubMedID: 20649590 |
| Gene_locus related to this paper: human-CES1 |
| Title : Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors - Young_2010_J.Med.Chem_53_8709 |
| Author(s) : Young BM , Hyatt JL , Bouck DC , Chen T , Hanumesh P , Price J , Boyd VA , Potter PM , Webb TR |
| Ref : Journal of Medicinal Chemistry , 53 :8709 , 2010 |
| Abstract : Young_2010_J.Med.Chem_53_8709 |
| ESTHER : Young_2010_J.Med.Chem_53_8709 |
| PubMedSearch : Young_2010_J.Med.Chem_53_8709 |
| PubMedID: 21105730 |
| Title : Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan\; CPT-11) toxicity - Hicks_2009_J.Med.Chem_52_3742 |
| Author(s) : Hicks LD , Hyatt JL , Stoddard S , Tsurkan L , Edwards CC , Wadkins RM , Potter PM |
| Ref : Journal of Medicinal Chemistry , 52 :3742 , 2009 |
| Abstract : Hicks_2009_J.Med.Chem_52_3742 |
| ESTHER : Hicks_2009_J.Med.Chem_52_3742 |
| PubMedSearch : Hicks_2009_J.Med.Chem_52_3742 |
| PubMedID: 19534556 |
| Title : Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug - Barthel_2008_J.Med.Chem_51_298 |
| Author(s) : Barthel BL , Torres RC , Hyatt JL , Edwards CC , Hatfield MJ , Potter PM , Koch TH |
| Ref : Journal of Medicinal Chemistry , 51 :298 , 2008 |
| Abstract : Barthel_2008_J.Med.Chem_51_298 |
| ESTHER : Barthel_2008_J.Med.Chem_51_298 |
| PubMedSearch : Barthel_2008_J.Med.Chem_51_298 |
| PubMedID: 18173233 |
| Title : An improved human carboxylesterase for enzyme\/prodrug therapy with CPT-11 - Wierdl_2008_Cancer.Gene.Ther_15_183 |
| Author(s) : Wierdl M , Tsurkan L , Hyatt JL , Edwards CC , Hatfield MJ , Morton CL , Houghton PJ , Danks MK , Redinbo MR , Potter PM |
| Ref : Cancer Gene Therapy , 15 :183 , 2008 |
| Abstract : Wierdl_2008_Cancer.Gene.Ther_15_183 |
| ESTHER : Wierdl_2008_Cancer.Gene.Ther_15_183 |
| PubMedSearch : Wierdl_2008_Cancer.Gene.Ther_15_183 |
| PubMedID: 18188187 |
| Title : Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1 - Hyatt_2007_J.Med.Chem_50_5727 |
| Author(s) : Hyatt JL , Wadkins RM , Tsurkan L , Hicks LD , Hatfield MJ , Edwards CC , Ross CR, 2nd , Cantalupo SA , Crundwell G , Danks MK , Guy RK , Potter PM |
| Ref : Journal of Medicinal Chemistry , 50 :5727 , 2007 |
| Abstract : Hyatt_2007_J.Med.Chem_50_5727 |
| ESTHER : Hyatt_2007_J.Med.Chem_50_5727 |
| PubMedSearch : Hyatt_2007_J.Med.Chem_50_5727 |
| PubMedID: 17941623 |
| Title : Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds - Wadkins_2007_Mol.Pharmacol_71_713 |
| Author(s) : Wadkins RM , Hyatt JL , Edwards CC , Tsurkan L , Redinbo MR , Wheelock CE , Jones PD , Hammock BD , Potter PM |
| Ref : Molecular Pharmacology , 71 :713 , 2007 |
| Abstract : Wadkins_2007_Mol.Pharmacol_71_713 |
| ESTHER : Wadkins_2007_Mol.Pharmacol_71_713 |
| PubMedSearch : Wadkins_2007_Mol.Pharmacol_71_713 |
| PubMedID: 17167034 |
| Title : Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils - Hicks_2007_Bioorg.Med.Chem_15_3801 |
| Author(s) : Hicks LD , Hyatt JL , Moak T , Edwards CC , Tsurkan L , Wierdl M , Ferreira AM , Wadkins RM , Potter PM |
| Ref : Bioorganic & Medicinal Chemistry , 15 :3801 , 2007 |
| Abstract : Hicks_2007_Bioorg.Med.Chem_15_3801 |
| ESTHER : Hicks_2007_Bioorg.Med.Chem_15_3801 |
| PubMedSearch : Hicks_2007_Bioorg.Med.Chem_15_3801 |
| PubMedID: 17399985 |
| Title : Selective inhibition of carboxylesterases by isatins, indole-2,3-diones - Hyatt_2007_J.Med.Chem_50_1876 |
| Author(s) : Hyatt JL , Moak T , Hatfield MJ , Tsurkan L , Edwards CC , Wierdl M , Danks MK , Wadkins RM , Potter PM |
| Ref : Journal of Medicinal Chemistry , 50 :1876 , 2007 |
| Abstract : Hyatt_2007_J.Med.Chem_50_1876 |
| ESTHER : Hyatt_2007_J.Med.Chem_50_1876 |
| PubMedSearch : Hyatt_2007_J.Med.Chem_50_1876 |
| PubMedID: 17378546 |
| Title : Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity - Hyatt_2006_Mol.Cancer.Ther_5_2281 |
| Author(s) : Hyatt JL , Tsurkan L , Wierdl M , Edwards CC , Danks MK , Potter PM |
| Ref : Mol Cancer Ther , 5 :2281 , 2006 |
| Abstract : Hyatt_2006_Mol.Cancer.Ther_5_2281 |
| ESTHER : Hyatt_2006_Mol.Cancer.Ther_5_2281 |
| PubMedSearch : Hyatt_2006_Mol.Cancer.Ther_5_2281 |
| PubMedID: 16985062 |
| Title : Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety - Hyatt_2005_J.Med.Chem_48_5543 |
| Author(s) : Hyatt JL , Stacy V , Wadkins RM , Yoon KJ , Wierdl M , Edwards CC , Zeller M , Hunter AD , Danks MK , Crundwell G , Potter PM |
| Ref : Journal of Medicinal Chemistry , 48 :5543 , 2005 |
| Abstract : Hyatt_2005_J.Med.Chem_48_5543 |
| ESTHER : Hyatt_2005_J.Med.Chem_48_5543 |
| PubMedSearch : Hyatt_2005_J.Med.Chem_48_5543 |
| PubMedID: 16107154 |
| Title : Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice - Morton_2005_Cancer.Chemother.Pharmacol_56_629 |
| Author(s) : Morton CL , Iacono L , Hyatt JL , Taylor KR , Cheshire PJ , Houghton PJ , Danks MK , Stewart CF , Potter PM |
| Ref : Cancer Chemother Pharmacol , 56 :629 , 2005 |
| Abstract : Morton_2005_Cancer.Chemother.Pharmacol_56_629 |
| ESTHER : Morton_2005_Cancer.Chemother.Pharmacol_56_629 |
| PubMedSearch : Morton_2005_Cancer.Chemother.Pharmacol_56_629 |
| PubMedID: 15918039 |
| Title : Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11 - Hyatt_2005_Chem.Biol.Interact_157-158_247 |
| Author(s) : Hyatt JL , Tsurkan L , Morton CL , Yoon KJ , Harel M , Brumshtein B , Silman I , Sussman JL , Wadkins RM , Potter PM |
| Ref : Chemico-Biological Interactions , 157-158 :247 , 2005 |
| Abstract : Hyatt_2005_Chem.Biol.Interact_157-158_247 |
| ESTHER : Hyatt_2005_Chem.Biol.Interact_157-158_247 |
| PubMedSearch : Hyatt_2005_Chem.Biol.Interact_157-158_247 |
| PubMedID: 16257398 |
| Title : The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase - Harel_2005_Chem.Biol.Interact_157-158_153 |
| Author(s) : Harel M , Hyatt JL , Brumshtein B , Morton CL , Wadkins RM , Silman I , Sussman JL , Potter PM |
| Ref : Chemico-Biological Interactions , 157-158 :153 , 2005 |
| Abstract : Harel_2005_Chem.Biol.Interact_157-158_153 |
| ESTHER : Harel_2005_Chem.Biol.Interact_157-158_153 |
| PubMedSearch : Harel_2005_Chem.Biol.Interact_157-158_153 |
| PubMedID: 16289500 |
| Gene_locus related to this paper: torca-ACHE |
| Title : The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action - Harel_2005_Mol.Pharmacol_67_1874 |
| Author(s) : Harel M , Hyatt JL , Brumshtein B , Morton CL , Yoon KJ , Wadkins RM , Silman I , Sussman JL , Potter PM |
| Ref : Molecular Pharmacology , 67 :1874 , 2005 |
| Abstract : Harel_2005_Mol.Pharmacol_67_1874 |
| ESTHER : Harel_2005_Mol.Pharmacol_67_1874 |
| PubMedSearch : Harel_2005_Mol.Pharmacol_67_1874 |
| PubMedID: 15772291 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil - Fleming_2005_J.Mol.Biol_352_165 |
| Author(s) : Fleming CD , Bencharit S , Edwards CC , Hyatt JL , Tsurkan L , Bai F , Fraga C , Morton CL , Howard-Williams EL , Potter PM , Redinbo MR |
| Ref : Journal of Molecular Biology , 352 :165 , 2005 |
| Abstract : Fleming_2005_J.Mol.Biol_352_165 |
| ESTHER : Fleming_2005_J.Mol.Biol_352_165 |
| PubMedSearch : Fleming_2005_J.Mol.Biol_352_165 |
| PubMedID: 16081098 |
| Gene_locus related to this paper: human-CES1 |
| Title : Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases - Wadkins_2005_J.Med.Chem_48_2906 |
| Author(s) : Wadkins RM , Hyatt JL , Wei X , Yoon KJ , Wierdl M , Edwards CC , Morton CL , Obenauer JC , Damodaran K , Beroza P , Danks MK , Potter PM |
| Ref : Journal of Medicinal Chemistry , 48 :2906 , 2005 |
| Abstract : Wadkins_2005_J.Med.Chem_48_2906 |
| ESTHER : Wadkins_2005_J.Med.Chem_48_2906 |
| PubMedSearch : Wadkins_2005_J.Med.Chem_48_2906 |
| PubMedID: 15828829 |
| Title : Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan - Tyminski_2005_Cancer.Res_65_6850 |
| Author(s) : Tyminski E , Leroy S , Terada K , Finkelstein DM , Hyatt JL , Danks MK , Potter PM , Saeki Y , Chiocca EA |
| Ref : Cancer Research , 65 :6850 , 2005 |
| Abstract : Tyminski_2005_Cancer.Res_65_6850 |
| ESTHER : Tyminski_2005_Cancer.Res_65_6850 |
| PubMedSearch : Tyminski_2005_Cancer.Res_65_6850 |
| PubMedID: 16061668 |
| Title : Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity - Wadkins_2004_Mol.Pharmacol_65_1336 |
| Author(s) : Wadkins RM , Hyatt JL , Yoon KJ , Morton CL , Lee RE , Damodaran K , Beroza P , Danks MK , Potter PM |
| Ref : Molecular Pharmacology , 65 :1336 , 2004 |
| Abstract : Wadkins_2004_Mol.Pharmacol_65_1336 |
| ESTHER : Wadkins_2004_Mol.Pharmacol_65_1336 |
| PubMedSearch : Wadkins_2004_Mol.Pharmacol_65_1336 |
| PubMedID: 15155827 |
| Title : Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application - Yoon_2004_Mol.Cancer.Ther_3_903 |
| Author(s) : Yoon KJ , Hyatt JL , Morton CL , Lee RE , Potter PM , Danks MK |
| Ref : Mol Cancer Ther , 3 :903 , 2004 |
| Abstract : Yoon_2004_Mol.Cancer.Ther_3_903 |
| ESTHER : Yoon_2004_Mol.Cancer.Ther_3_903 |
| PubMedSearch : Yoon_2004_Mol.Cancer.Ther_3_903 |
| PubMedID: 15299073 |
| Title : Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition - Bencharit_2003_Chem.Biol_10_341 |
| Author(s) : Bencharit S , Morton CL , Hyatt JL , Kuhn P , Danks MK , Potter PM , Redinbo MR |
| Ref : Chemical Biology , 10 :341 , 2003 |
| Abstract : Bencharit_2003_Chem.Biol_10_341 |
| ESTHER : Bencharit_2003_Chem.Biol_10_341 |
| PubMedSearch : Bencharit_2003_Chem.Biol_10_341 |
| PubMedID: 12725862 |
| Gene_locus related to this paper: human-CES1 |