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References (40)

Title : Bioconversion and P-gp-mediated transport of depot fluphenazine prodrugs after intramuscular injection - Ohura_2023_J.Pharm.Sci__
Author(s) : Ohura K , Nakada Y , Imai T
Ref : J Pharm Sci , : , 2023
Abstract : Ohura_2023_J.Pharm.Sci__
ESTHER : Ohura_2023_J.Pharm.Sci__
PubMedSearch : Ohura_2023_J.Pharm.Sci__
PubMedID: 37019360

Title : Esterases Involved in the Rapid Bioconversion of Esmolol after Intravenous Injection in Humans - Imai_2022_Biol.Pharm.Bull_45_1544
Author(s) : Imai T , Isozaki M , Ohura K
Ref : Biol Pharm Bull , 45 :1544 , 2022
Abstract : Imai_2022_Biol.Pharm.Bull_45_1544
ESTHER : Imai_2022_Biol.Pharm.Bull_45_1544
PubMedSearch : Imai_2022_Biol.Pharm.Bull_45_1544
PubMedID: 36184514

Title : Identification and Characterization of a New Carboxylesterase 2 Isozyme, mfCES2C, in the Small Intestine of Cynomolgus Monkeys - Ohura_2020_Drug.Metab.Dispos_48_146
Author(s) : Ohura K , Igawa Y , Tanaka M , Matsumoto K , Kasahara A , Wada N , Kubota K , Uno Y , Imai T
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 48 :146 , 2020
Abstract : Ohura_2020_Drug.Metab.Dispos_48_146
ESTHER : Ohura_2020_Drug.Metab.Dispos_48_146
PubMedSearch : Ohura_2020_Drug.Metab.Dispos_48_146
PubMedID: 31836607
Gene_locus related to this paper: macfa-a0a2k5uar1

Title : Effect of Calcium on the Hydrolysis Activity of Human Butyrylcholinesterase - Imai_2020_J.Pharm.Sci_109_1417
Author(s) : Imai T , Bahar FG , Ohura K , Toda A
Ref : J Pharm Sci , 109 :1417 , 2020
Abstract : Imai_2020_J.Pharm.Sci_109_1417
ESTHER : Imai_2020_J.Pharm.Sci_109_1417
PubMedSearch : Imai_2020_J.Pharm.Sci_109_1417
PubMedID: 31837977

Title : [Comparative Study of Hydrolase Activity in Skin with Liver and Intestine, and Its Aging Relation of Carboxylesterase Expression in Cynomolgus Monkey and Beagle Dog] - Imai_2019_Yakugaku.Zasshi_139_837
Author(s) : Imai T , Nakada Y , Ohura K
Ref : Yakugaku Zasshi , 139 :837 , 2019
Abstract : Imai_2019_Yakugaku.Zasshi_139_837
ESTHER : Imai_2019_Yakugaku.Zasshi_139_837
PubMedSearch : Imai_2019_Yakugaku.Zasshi_139_837
PubMedID: 31061351

Title : Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies - Ishizaki_2018_Biol.Pharm.Bull_41_697
Author(s) : Ishizaki Y , Furihata T , Oyama Y , Ohura K , Imai T , Hosokawa M , Akita H , Chiba K
Ref : Biol Pharm Bull , 41 :697 , 2018
Abstract : Ishizaki_2018_Biol.Pharm.Bull_41_697
ESTHER : Ishizaki_2018_Biol.Pharm.Bull_41_697
PubMedSearch : Ishizaki_2018_Biol.Pharm.Bull_41_697
PubMedID: 29709907

Title : Prescription of Antidementia Drugs and Antipsychotics for Elderly Patients in Japan: A Descriptive Study Using Pharmacy Prescription Data - Tsukada_2018_J.Geriatr.Psychiatry.Neurol__891988718785775
Author(s) : Tsukada T , Sato I , Matsuoka N , Imai T , Doi Y , Arai M , Fujii Y , Matsunaga T , Kawakami K
Ref : J Geriatr Psychiatry Neurol , :891988718785775 , 2018
Abstract : Tsukada_2018_J.Geriatr.Psychiatry.Neurol__891988718785775
ESTHER : Tsukada_2018_J.Geriatr.Psychiatry.Neurol__891988718785775
PubMedSearch : Tsukada_2018_J.Geriatr.Psychiatry.Neurol__891988718785775
PubMedID: 30016896

Title : Molecular characterization and polymorphisms of butyrylcholinesterase in cynomolgus macaques - Uno_2018_J.Med.Primatol_47_185
Author(s) : Uno Y , Uehara S , Mahadhi HMD , Ohura K , Hosokawa M , Imai T
Ref : J Med Primatol , 47 :185 , 2018
Abstract : Uno_2018_J.Med.Primatol_47_185
ESTHER : Uno_2018_J.Med.Primatol_47_185
PubMedSearch : Uno_2018_J.Med.Primatol_47_185
PubMedID: 29573432
Gene_locus related to this paper: macfa-BCHE

Title : A novel quantification method for serine hydrolases in cellular expression system using fluorophosphonate-biotin probe - Abdel-Daim_2018_Eur.J.Pharm.Sci_114_267
Author(s) : Abdel-Daim A , Ohura K , Imai T
Ref : Eur J Pharm Sci , 114 :267 , 2018
Abstract : Abdel-Daim_2018_Eur.J.Pharm.Sci_114_267
ESTHER : Abdel-Daim_2018_Eur.J.Pharm.Sci_114_267
PubMedSearch : Abdel-Daim_2018_Eur.J.Pharm.Sci_114_267
PubMedID: 29289670

Title : Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver - Uno_2018_Xenobiotica__1
Author(s) : Uno Y , Igawa Y , Tanaka M , Kayoko O , Hosokawa M , Imai T
Ref : Xenobiotica , :1 , 2018
Abstract : Uno_2018_Xenobiotica__1
ESTHER : Uno_2018_Xenobiotica__1
PubMedSearch : Uno_2018_Xenobiotica__1
PubMedID: 29384423

Title : Development of simultaneous quantification method of loteprednol etabonate (LE) and its acidic metabolites, and analysis of LE metabolism in rat - Samir_2018_Xenobiotica__1
Author(s) : Samir A , Kage A , Kayoko O , Imai T
Ref : Xenobiotica , :1 , 2018
Abstract : Samir_2018_Xenobiotica__1
ESTHER : Samir_2018_Xenobiotica__1
PubMedSearch : Samir_2018_Xenobiotica__1
PubMedID: 29781759

Title : Effect of alcohol on skin permeation and metabolism of an ester-type prodrug in Yucatan micropig skin - Fujii_2017_Eur.J.Pharm.Sci_109_280
Author(s) : Fujii M , Ohara R , Matsumi A , Ohura K , Koizumi N , Imai T , Watanabe Y
Ref : Eur J Pharm Sci , 109 :280 , 2017
Abstract : Fujii_2017_Eur.J.Pharm.Sci_109_280
ESTHER : Fujii_2017_Eur.J.Pharm.Sci_109_280
PubMedSearch : Fujii_2017_Eur.J.Pharm.Sci_109_280
PubMedID: 28821439

Title : Expression of Carboxylesterase Isozymes and Their Role in the Behavior of a Fexofenadine Prodrug in Rat Skin - Imai_2016_J.Pharm.Sci_105_714
Author(s) : Imai T , Ariyoshi S , Ohura K , Sawada T , Nakada Y
Ref : J Pharm Sci , 105 :714 , 2016
Abstract : Imai_2016_J.Pharm.Sci_105_714
ESTHER : Imai_2016_J.Pharm.Sci_105_714
PubMedSearch : Imai_2016_J.Pharm.Sci_105_714
PubMedID: 26444870

Title : Establishment and Characterization of a Novel Caco-2 Subclone with a Similar Low Expression Level of Human Carboxylesterase 1 to Human Small Intestine - Ohura_2016_Drug.Metab.Dispos_44_1890
Author(s) : Ohura K , Nishiyama H , Saco S , Kurokawa K , Imai T
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 44 :1890 , 2016
Abstract : Ohura_2016_Drug.Metab.Dispos_44_1890
ESTHER : Ohura_2016_Drug.Metab.Dispos_44_1890
PubMedSearch : Ohura_2016_Drug.Metab.Dispos_44_1890
PubMedID: 27638507
Gene_locus related to this paper: human-CES1

Title : Differences in Intestinal Hydrolytic Activities between Cynomolgus Monkeys and Humans: Evaluation of Substrate Specificities Using Recombinant Carboxylesterase 2 Isozymes - Igawa_2016_Mol.Pharm_13_3176
Author(s) : Igawa Y , Fujiwara S , Ohura K , Hirokawa T , Nishizawa Y , Uehara S , Uno Y , Imai T
Ref : Mol Pharm , 13 :3176 , 2016
Abstract : Igawa_2016_Mol.Pharm_13_3176
ESTHER : Igawa_2016_Mol.Pharm_13_3176
PubMedSearch : Igawa_2016_Mol.Pharm_13_3176
PubMedID: 27454346

Title : Design of Fexofenadine Prodrugs Based on Tissue-Specific Esterase Activity and Their Dissimilar Recognition by P-Glycoprotein - Ohura_2015_J.Pharm.Sci_104_3076
Author(s) : Ohura K , Nakada Y , Kotani S , Imai T
Ref : J Pharm Sci , 104 :3076 , 2015
Abstract : Ohura_2015_J.Pharm.Sci_104_3076
ESTHER : Ohura_2015_J.Pharm.Sci_104_3076
PubMedSearch : Ohura_2015_J.Pharm.Sci_104_3076
PubMedID: 25953731

Title : 3D-fibroblast tissues constructed by a cell-coat technology enhance tight-junction formation of human colon epithelial cells - Matsusaki_2015_Biochem.Biophys.Res.Commun_457_363
Author(s) : Matsusaki M , Hikimoto D , Nishiguchi A , Kadowaki K , Ohura K , Imai T , Akashi M
Ref : Biochemical & Biophysical Research Communications , 457 :363 , 2015
Abstract : Matsusaki_2015_Biochem.Biophys.Res.Commun_457_363
ESTHER : Matsusaki_2015_Biochem.Biophys.Res.Commun_457_363
PubMedSearch : Matsusaki_2015_Biochem.Biophys.Res.Commun_457_363
PubMedID: 25576862

Title : Isolation and characterization of arylacetamide deacetylase in cynomolgus macaques - Uno_2015_J.Vet.Med.Sci_77_721
Author(s) : Uno Y , Hosokawa M , Imai T
Ref : J Vet Med Sci , 77 :721 , 2015
Abstract : Uno_2015_J.Vet.Med.Sci_77_721
ESTHER : Uno_2015_J.Vet.Med.Sci_77_721
PubMedSearch : Uno_2015_J.Vet.Med.Sci_77_721
PubMedID: 25715734

Title : Monitoring of the effects of transfection with baculovirus on Sf9 cell line and expression of human dipeptidyl peptidase IV - Ustun-Aytekin_2014_Cytotech_66_159
Author(s) : Ustun-Aytekin O , Gurhan ID , Ohura K , Imai T , Ongen G
Ref : Cytotechnology , 66 :159 , 2014
Abstract : Ustun-Aytekin_2014_Cytotech_66_159
ESTHER : Ustun-Aytekin_2014_Cytotech_66_159
PubMedSearch : Ustun-Aytekin_2014_Cytotech_66_159
PubMedID: 23715645

Title : Systematic identification and characterization of carboxylesterases in cynomolgus macaques - Uno_2014_Drug.Metab.Dispos_42_2002
Author(s) : Uno Y , Uehara S , Hosokawa M , Imai T
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :2002 , 2014
Abstract : Uno_2014_Drug.Metab.Dispos_42_2002
ESTHER : Uno_2014_Drug.Metab.Dispos_42_2002
PubMedSearch : Uno_2014_Drug.Metab.Dispos_42_2002
PubMedID: 25256558
Gene_locus related to this paper: macfa-CES1v2 , macfa-CES1v1 , macfa-CES5 , macfa-CES2v3

Title : Quality of life in purely ocular myasthenia in Japan - Suzuki_2014_BMC.Neurol_14_142
Author(s) : Suzuki S , Murai H , Imai T , Nagane Y , Masuda M , Tsuda E , Konno S , Oji S , Nakane S , Motomura M , Suzuki N , Utsugisawa K
Ref : BMC Neurol , 14 :142 , 2014
Abstract : Suzuki_2014_BMC.Neurol_14_142
ESTHER : Suzuki_2014_BMC.Neurol_14_142
PubMedSearch : Suzuki_2014_BMC.Neurol_14_142
PubMedID: 24996227

Title : Distinct patterns of aging effects on the expression and activity of carboxylesterases in rat liver and intestine - Ohura_2014_Drug.Metab.Dispos_42_264
Author(s) : Ohura K , Tasaka K , Hashimoto M , Imai T
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :264 , 2014
Abstract : Ohura_2014_Drug.Metab.Dispos_42_264
ESTHER : Ohura_2014_Drug.Metab.Dispos_42_264
PubMedSearch : Ohura_2014_Drug.Metab.Dispos_42_264
PubMedID: 24271336
Gene_locus related to this paper: human-CES1

Title : Aspirin hydrolysis in human and experimental animal plasma and the effect of metal cations on hydrolase activities - Bahar_2013_Drug.Metab.Dispos_41_1450
Author(s) : Bahar FG , Imai T
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 41 :1450 , 2013
Abstract : Bahar_2013_Drug.Metab.Dispos_41_1450
ESTHER : Bahar_2013_Drug.Metab.Dispos_41_1450
PubMedSearch : Bahar_2013_Drug.Metab.Dispos_41_1450
PubMedID: 23649702

Title : Involvement of Carboxylesterase in Hydrolysis of Propranolol Prodrug during Permeation across Rat Skin - Imai_2013_Pharmaceutics_5_371
Author(s) : Imai T , Takase Y , Iwase H , Hashimoto M
Ref : Pharmaceutics , 5 :371 , 2013
Abstract : Imai_2013_Pharmaceutics_5_371
ESTHER : Imai_2013_Pharmaceutics_5_371
PubMedSearch : Imai_2013_Pharmaceutics_5_371
PubMedID: 24300511

Title : Species difference of esterase expression and hydrolase activity in plasma - Bahar_2012_J.Pharm.Sci_101_3979
Author(s) : Bahar FG , Ohura K , Ogihara T , Imai T
Ref : J Pharm Sci , 101 :3979 , 2012
Abstract : Bahar_2012_J.Pharm.Sci_101_3979
ESTHER : Bahar_2012_J.Pharm.Sci_101_3979
PubMedSearch : Bahar_2012_J.Pharm.Sci_101_3979
PubMedID: 22833171

Title : Prediction of human intestinal absorption of the prodrug temocapril by in situ single-pass perfusion using rat intestine with modified hydrolase activity - Nozawa_2011_Drug.Metab.Dispos_39_1263
Author(s) : Nozawa T , Imai T
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 39 :1263 , 2011
Abstract : Nozawa_2011_Drug.Metab.Dispos_39_1263
ESTHER : Nozawa_2011_Drug.Metab.Dispos_39_1263
PubMedSearch : Nozawa_2011_Drug.Metab.Dispos_39_1263
PubMedID: 21474683

Title : Evaluation of transport mechanism of prodrugs and parent drugs formed by intracellular metabolism in Caco-2 cells with modified carboxylesterase activity: temocapril as a model case - Ohura_2011_J.Pharm.Sci_100_3985
Author(s) : Ohura K , Nozawa T , Murakami K , Imai T
Ref : J Pharm Sci , 100 :3985 , 2011
Abstract : Ohura_2011_J.Pharm.Sci_100_3985
ESTHER : Ohura_2011_J.Pharm.Sci_100_3985
PubMedSearch : Ohura_2011_J.Pharm.Sci_100_3985
PubMedID: 21618543

Title : Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins - Holmes_2010_Mamm.Genome_21_427
Author(s) : Holmes RS , Wright MW , Laulederkind SJ , Cox LA , Hosokawa M , Imai T , Ishibashi S , Lehner R , Miyazaki M , Perkins EJ , Potter PM , Redinbo MR , Robert J , Satoh T , Yamashita T , Yan B , Yokoi T , Zechner R , Maltais LJ
Ref : Mamm Genome , 21 :427 , 2010
Abstract : Holmes_2010_Mamm.Genome_21_427
ESTHER : Holmes_2010_Mamm.Genome_21_427
PubMedSearch : Holmes_2010_Mamm.Genome_21_427
PubMedID: 20931200
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A

Title : The role of intestinal carboxylesterase in the oral absorption of prodrugs - Imai_2010_Curr.Drug.Metab_11_793
Author(s) : Imai T , Ohura K
Ref : Curr Drug Metab , 11 :793 , 2010
Abstract : Imai_2010_Curr.Drug.Metab_11_793
ESTHER : Imai_2010_Curr.Drug.Metab_11_793
PubMedSearch : Imai_2010_Curr.Drug.Metab_11_793
PubMedID: 21189138

Title : Prodrug approach using carboxylesterases activity: catalytic properties and gene regulation of carboxylesterase in mammalian tissue - Imai_2010_J.Pestic.Sci_35_229
Author(s) : Imai T , Hosokawa M
Ref : Journal of Pesticide Science , 35 :229 , 2010
Abstract : Imai_2010_J.Pestic.Sci_35_229
ESTHER : Imai_2010_J.Pestic.Sci_35_229
PubMedSearch : Imai_2010_J.Pestic.Sci_35_229
PubMedID:

Title : Development of a novel system for estimating human intestinal absorption using Caco-2 cells in the absence of esterase activity - Ohura_2010_Drug.Metab.Dispos_38_323
Author(s) : Ohura K , Sakamoto H , Ninomiya S , Imai T
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 38 :323 , 2010
Abstract : Ohura_2010_Drug.Metab.Dispos_38_323
ESTHER : Ohura_2010_Drug.Metab.Dispos_38_323
PubMedSearch : Ohura_2010_Drug.Metab.Dispos_38_323
PubMedID: 19923255

Title : [Carboxylesterase: from drug metabolism to drug discovery] -
Author(s) : Imai T
Ref : Nihon Yakurigaku Zasshi , 134 :281 , 2009
PubMedID: 19915289

Title : Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroidal type 2 iodothyronine deiodinase activity - Kanou_2007_J.Clin.Endocrinol.Metab_92_1451
Author(s) : Kanou Y , Hishinuma A , Tsunekawa K , Seki K , Mizuno Y , Fujisawa H , Imai T , Miura Y , Nagasaka T , Yamada C , Ieiri T , Murakami M , Murata Y
Ref : J Clinical Endocrinology Metab , 92 :1451 , 2007
Abstract : Kanou_2007_J.Clin.Endocrinol.Metab_92_1451
ESTHER : Kanou_2007_J.Clin.Endocrinol.Metab_92_1451
PubMedSearch : Kanou_2007_J.Clin.Endocrinol.Metab_92_1451
PubMedID: 17244789

Title : Carboxylesterase in the liver and small intestine of experimental animals and human - Taketani_2007_Life.Sci_81_924
Author(s) : Taketani M , Shii M , Ohura K , Ninomiya S , Imai T
Ref : Life Sciences , 81 :924 , 2007
Abstract : Taketani_2007_Life.Sci_81_924
ESTHER : Taketani_2007_Life.Sci_81_924
PubMedSearch : Taketani_2007_Life.Sci_81_924
PubMedID: 17764701

Title : Involvement of up-regulation of hepatic breast cancer resistance protein in decreased plasma concentration of 7-ethyl-10-hydroxycamptothecin (SN-38) by coadministration of S-1 in rats - Yokoo_2007_Drug.Metab.Dispos_35_1511
Author(s) : Yokoo K , Hamada A , Watanabe H , Matsuzaki T , Imai T , Fujimoto H , Masa K , Saito H
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 35 :1511 , 2007
Abstract : Yokoo_2007_Drug.Metab.Dispos_35_1511
ESTHER : Yokoo_2007_Drug.Metab.Dispos_35_1511
PubMedSearch : Yokoo_2007_Drug.Metab.Dispos_35_1511
PubMedID: 17537871

Title : [Hydrolysis by carboxylesterase and disposition of prodrug with ester moiety] - Imai_2007_Yakugaku.Zasshi_127_611
Author(s) : Imai T
Ref : Yakugaku Zasshi , 127 :611 , 2007
Abstract : Imai_2007_Yakugaku.Zasshi_127_611
ESTHER : Imai_2007_Yakugaku.Zasshi_127_611
PubMedSearch : Imai_2007_Yakugaku.Zasshi_127_611
PubMedID: 17409690

Title : Assessment of induction of cytochrome P450 by NO-1886 (ibrolipim), a lipoprotein lipase-promoting agent, in primary cultures of human hepatocytes and in female rat liver - Morioka_2006_Drug.Metab.Pharmacokinet_21_19
Author(s) : Morioka Y , Nishimura M , Imai T , Suzuki S , Harada M , Satoh T , Naito S
Ref : Drug Metab Pharmacokinet , 21 :19 , 2006
Abstract : Morioka_2006_Drug.Metab.Pharmacokinet_21_19
ESTHER : Morioka_2006_Drug.Metab.Pharmacokinet_21_19
PubMedSearch : Morioka_2006_Drug.Metab.Pharmacokinet_21_19
PubMedID: 16547390

Title : Human carboxylesterase isozymes: catalytic properties and rational drug design - Imai_2006_Drug.Metab.Pharmacokinet_21_173
Author(s) : Imai T
Ref : Drug Metab Pharmacokinet , 21 :173 , 2006
Abstract : Imai_2006_Drug.Metab.Pharmacokinet_21_173
ESTHER : Imai_2006_Drug.Metab.Pharmacokinet_21_173
PubMedSearch : Imai_2006_Drug.Metab.Pharmacokinet_21_173
PubMedID: 16858120
Gene_locus related to this paper: human-CES1

Title : Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine - Imai_2006_Drug.Metab.Dispos_34_1734
Author(s) : Imai T , Taketani M , Shii M , Hosokawa M , Chiba K
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 34 :1734 , 2006
Abstract : Imai_2006_Drug.Metab.Dispos_34_1734
ESTHER : Imai_2006_Drug.Metab.Dispos_34_1734
PubMedSearch : Imai_2006_Drug.Metab.Dispos_34_1734
PubMedID: 16837570
Gene_locus related to this paper: human-CES1 , human-CES2

Title : Effects of NO-1886 (Ibrolipim), a lipoprotein lipase-promoting agent, on gene induction of cytochrome P450s, carboxylesterases, and sulfotransferases in primary cultures of human hepatocytes - Nishimura_2004_Drug.Metab.Pharmacokinet_19_422
Author(s) : Nishimura M , Imai T , Morioka Y , Kuribayashi S , Kamataki T , Naito S
Ref : Drug Metab Pharmacokinet , 19 :422 , 2004
Abstract : Nishimura_2004_Drug.Metab.Pharmacokinet_19_422
ESTHER : Nishimura_2004_Drug.Metab.Pharmacokinet_19_422
PubMedSearch : Nishimura_2004_Drug.Metab.Pharmacokinet_19_422
PubMedID: 15681896