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Author Report for: Kim GT

Title: Synthesis, SAR, and X-ray structure of novel potent DPPIV inhibitors: oxadiazolyl ketones
Koo KD, Kim MJ, Kim S, Kim KH, Hong SY, Hur GC, Yim HJ, Kim GT, Han HO and Lee CS <3 more author(s)> Koo KD, Kim MJ, Kim S, Kim KH, Hong SY, Hur GC, Yim HJ, Kim GT, Han HO, Kwon OH, Kwon TS, Koh JS, Lee CS (- 3)
Ref: Bioorganic & Medicinal Chemistry Lett, 17:4167, 2007 : PubMed
Abstract


ESTHER: Koo_2007_Bioorg.Med.Chem.Lett_17_4167
PubMedSearch: Koo 2007 Bioorg.Med.Chem.Lett 17 4167
PubMedID: 17544668
Gene_locus related to this paper: human-DPP4
Inhibitor(s) related to this paper: 1,3,4-oxadiazolyl-ketone-18h

Abstract

Synthesis of a novel series of DPPIV inhibitors with 1,2,4- and 1,3,4-oxadiazolyl ketone derivatives and its structure-activity relationships are discussed. Compound 18h showed good inhibitory activity against DPPIV and favorable pharmacokinetic properties. In vivo pharmacodynamic efficacy and co-crystal structure of compound 18h with DPPIV is also described.