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Author Report for: Klenk H-P

Title: The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea.
Deppenmeier U, Johann A, Hartsch T, Merkl R, Martinez-Arias R, Henne A, Wiezer A, Baeumer S, Brueggemann H and Fritz H-J <7 more author(s)> Deppenmeier U, Johann A, Hartsch T, Merkl R, Martinez-Arias R, Henne A, Wiezer A, Baeumer S, Brueggemann H, Lienard T, Christmann A, Boemecke M, Bhattacharyya A, Lykidis A, Overbeek R, Klenk H-P, Fritz H-J (- 7)
Ref: J Mol Microbiol Biotechnol, 4:453, 2002 : PubMed
Abstract


ESTHER: Deppenmeier_2002_J.Mol.Microbiol.Biotechnol_4_453
PubMedSearch: Deppenmeier 2002 J.Mol.Microbiol.Biotechnol 4 453
PubMedID: 12125824
Gene_locus related to this paper: metma-MM0529, metma-MM1373, metma-MM2426, metma-MM2553, metma-MM2650, metma-MM3122, metma-MM3198, metma-MM3308, metma-q8pw23



        

Title: The complete genome sequence of the gastric pathogen Helicobacter pylori.
Tomb J-F, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk H-P, Gill S and Venter JC <32 more author(s)> Tomb J-F, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk H-P, Gill S, Dougherty BA, Nelson K, Quackenbush J, Zhou L, Kirkness EF, Peterson S, Loftus B, Richardson D, Dodson R, Khalak HG, Glodek A, McKenney K, FitzGerald LM, Lee N, Adams MD, Hickey EK, Berg DE, Gocayne JD, Utterback TR, Peterson JD, Kelley JM, Cotton MD, Weidman JM, Fujii C, Bowman C, Watthey L, Wallin E, Hayes WS, Borodovsky M, Karp PD, Smith HO, Fraser CM, Venter JC (- 32)
Ref: Nature, 388:539, 1997 : PubMed
Abstract


ESTHER: Tomb_1997_Nature_388_539
PubMedSearch: Tomb 1997 Nature 388 539
PubMedID: 9252185
Gene_locus related to this paper: helpy-HP0739, helpy-o25061

Abstract

Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host-pathogen interaction. Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic variation and adaptive evolution. Consistent with its restricted niche, H. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH.