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| Title : Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer's Disease Treatment through Rigidification Strategy - Lecoutey_2021_Molecules_26_ |
| Author(s) : Lecoutey C , Legay R , Davis A , Sopkova-de Oliveira Santos J , Dallemagne P , Rochais C |
| Ref : Molecules , 26 : , 2021 |
| Abstract : Lecoutey_2021_Molecules_26_ |
| ESTHER : Lecoutey_2021_Molecules_26_ |
| PubMedSearch : Lecoutey_2021_Molecules_26_ |
| PubMedID: 33926141 |
| Title : Donecopride, a Swiss army knife with potential against Alzheimer's disease - Rochais_2020_Br.J.Pharmacol_177_1988 |
| Author(s) : Rochais C , Lecoutey C , Hamidouche K , Giannoni P , Gaven F , Cem E , Mignani S , Baranger K , Freret T , Bockaert J , Rivera S , Boulouard M , Dallemagne P , Claeysen S |
| Ref : British Journal of Pharmacology , 177 :1988 , 2020 |
| Abstract : Rochais_2020_Br.J.Pharmacol_177_1988 |
| ESTHER : Rochais_2020_Br.J.Pharmacol_177_1988 |
| PubMedSearch : Rochais_2020_Br.J.Pharmacol_177_1988 |
| PubMedID: 31881553 |
| Title : First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer's Disease - Guieu_2020_Molecules_26_ |
| Author(s) : Guieu B , Lecoutey C , Legay R , Davis A , Sopkova de Oliveira Santos J , Altomare CD , Catto M , Rochais C , Dallemagne P |
| Ref : Molecules , 26 : , 2020 |
| Abstract : Guieu_2020_Molecules_26_ |
| ESTHER : Guieu_2020_Molecules_26_ |
| PubMedSearch : Guieu_2020_Molecules_26_ |
| PubMedID: 33375412 |
| Title : Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT(6) receptor antagonist with therapeutic interest in Alzheimer's disease - Toublet_2020_Eur.J.Med.Chem_210_113059 |
| Author(s) : Toublet FX , Lalut J , Hatat B , Lecoutey C , Davis A , Since M , Corvaisier S , Freret T , Sopkova-de Oliveira Santos J , Claeysen S , Boulouard M , Dallemagne P , Rochais C |
| Ref : Eur Journal of Medicinal Chemistry , 210 :113059 , 2020 |
| Abstract : Toublet_2020_Eur.J.Med.Chem_210_113059 |
| ESTHER : Toublet_2020_Eur.J.Med.Chem_210_113059 |
| PubMedSearch : Toublet_2020_Eur.J.Med.Chem_210_113059 |
| PubMedID: 33310288 |
| Title : Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer's disease - Lalut_2020_Sci.Rep_10_3014 |
| Author(s) : Lalut J , Payan H , Davis A , Lecoutey C , Legay R , Sopkova-de Oliveira Santos J , Claeysen S , Dallemagne P , Rochais C |
| Ref : Sci Rep , 10 :3014 , 2020 |
| Abstract : Lalut_2020_Sci.Rep_10_3014 |
| ESTHER : Lalut_2020_Sci.Rep_10_3014 |
| PubMedSearch : Lalut_2020_Sci.Rep_10_3014 |
| PubMedID: 32080261 |
| Title : A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer's Disease - Hatat_2019_Front.Aging.Neurosci_11_148 |
| Author(s) : Hatat B , Yahiaoui S , Lecoutey C , Davis A , Freret T , Boulouard M , Claeysen S , Rochais C , Dallemagne P |
| Ref : Front Aging Neurosci , 11 :148 , 2019 |
| Abstract : Hatat_2019_Front.Aging.Neurosci_11_148 |
| ESTHER : Hatat_2019_Front.Aging.Neurosci_11_148 |
| PubMedSearch : Hatat_2019_Front.Aging.Neurosci_11_148 |
| PubMedID: 31316368 |
| Title : Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease - Toublet_2019_Molecules_24_ |
| Author(s) : Toublet FX , Lecoutey C , Lalut J , Hatat B , Davis A , Since M , Corvaisier S , Freret T , Sopkova de Oliveira Santos J , Claeysen S , Boulouard M , Dallemagne P , Rochais C |
| Ref : Molecules , 24 : , 2019 |
| Abstract : Toublet_2019_Molecules_24_ |
| ESTHER : Toublet_2019_Molecules_24_ |
| PubMedSearch : Toublet_2019_Molecules_24_ |
| PubMedID: 31370232 |
| Title : Novel multitarget-directed ligands targeting acetylcholinesterase and sigma1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase - Lalut_2019_Eur.J.Med.Chem_162_234 |
| Author(s) : Lalut J , Santoni G , Karila D , Lecoutey C , Davis A , Nachon F , Silman I , Sussman JL , Weik M , Maurice T , Dallemagne P , Rochais C |
| Ref : Eur Journal of Medicinal Chemistry , 162 :234 , 2019 |
| Abstract : Lalut_2019_Eur.J.Med.Chem_162_234 |
| ESTHER : Lalut_2019_Eur.J.Med.Chem_162_234 |
| PubMedSearch : Lalut_2019_Eur.J.Med.Chem_162_234 |
| PubMedID: 30447434 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Synthesis and biological evaluation of pyrano[4,3-b][1]benzopyranone derivatives as monoamine oxidase and cholinesterase inhibitors - Lecoutey_2012_MedChemComm_3_627 |
| Author(s) : Lecoutey C , Rochais C , Genest D , Butt-Gueulle S , Ballandonne C , Corvaisier S , Dulin F , Lepailleur A , Sopkova-de , Dallemagne P |
| Ref : Medchemcomm , 33 :627 , 2018 |
| Abstract : Lecoutey_2012_MedChemComm_3_627 |
| ESTHER : Lecoutey_2012_MedChemComm_3_627 |
| PubMedSearch : Lecoutey_2012_MedChemComm_3_627 |
| PubMedID: |
| Title : Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment - Jourdan_2017_ChemMedChem_12_913 |
| Author(s) : Jourdan JP , Since M , El Kihel L , Lecoutey C , Corvaisier S , Legay R , Sopkova-de Oliveira Santos J , Cresteil T , Malzert-Freon A , Rochais C , Dallemagne P |
| Ref : ChemMedChem , 12 :913 , 2017 |
| Abstract : Jourdan_2017_ChemMedChem_12_913 |
| ESTHER : Jourdan_2017_ChemMedChem_12_913 |
| PubMedSearch : Jourdan_2017_ChemMedChem_12_913 |
| PubMedID: 28342294 |
| Title : Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment - Jourdan_2016_Eur.J.Med.Chem_114_365 |
| Author(s) : Jourdan JP , Since M , El Kihel L , Lecoutey C , Corvaisier S , Legay R , Sopkova-de Oliveira Santos J , Cresteil T , Malzert-Freon A , Rochais C , Dallemagne P |
| Ref : Eur Journal of Medicinal Chemistry , 114 :365 , 2016 |
| Abstract : Jourdan_2016_Eur.J.Med.Chem_114_365 |
| ESTHER : Jourdan_2016_Eur.J.Med.Chem_114_365 |
| PubMedSearch : Jourdan_2016_Eur.J.Med.Chem_114_365 |
| PubMedID: 27046230 |
| Title : Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography - Lalut_2016_Eur.J.Med.Chem_116_90 |
| Author(s) : Lalut J , Tournier BB , Cailly T , Lecoutey C , Corvaisier S , Davis A , Ballandonne C , Since M , Millet P , Fabis F , Dallemagne P , Rochais C |
| Ref : Eur Journal of Medicinal Chemistry , 116 :90 , 2016 |
| Abstract : Lalut_2016_Eur.J.Med.Chem_116_90 |
| ESTHER : Lalut_2016_Eur.J.Med.Chem_116_90 |
| PubMedSearch : Lalut_2016_Eur.J.Med.Chem_116_90 |
| PubMedID: 27060761 |
| Title : Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride - Rochais_2015_J.Med.Chem_58_3172 |
| Author(s) : Rochais C , Lecoutey C , Gaven F , Giannoni P , Hamidouche K , Hedou D , Dubost E , Genest D , Yahiaoui S , Freret T , Bouet V , Dauphin F , Sopkova de Oliveira Santos J , Ballandonne C , Corvaisier S , Malzert-Freon A , Legay R , Boulouard M , Claeysen S , Dallemagne P |
| Ref : Journal of Medicinal Chemistry , 58 :3172 , 2015 |
| Abstract : Rochais_2015_J.Med.Chem_58_3172 |
| ESTHER : Rochais_2015_J.Med.Chem_58_3172 |
| PubMedSearch : Rochais_2015_J.Med.Chem_58_3172 |
| PubMedID: 25793650 |
| Title : Design of donecopride, a dual serotonin subtype 4 receptor agonist\/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment - Lecoutey_2014_Proc.Natl.Acad.Sci.U.S.A_111_E3825 |
| Author(s) : Lecoutey C , Hedou D , Freret T , Giannoni P , Gaven F , Since M , Bouet V , Ballandonne C , Corvaisier S , Malzert Freon A , Mignani S , Cresteil T , Boulouard M , Claeysen S , Rochais C , Dallemagne P |
| Ref : Proc Natl Acad Sci U S A , 111 :E3825 , 2014 |
| Abstract : Lecoutey_2014_Proc.Natl.Acad.Sci.U.S.A_111_E3825 |
| ESTHER : Lecoutey_2014_Proc.Natl.Acad.Sci.U.S.A_111_E3825 |
| PubMedSearch : Lecoutey_2014_Proc.Natl.Acad.Sci.U.S.A_111_E3825 |
| PubMedID: 25157130 |