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Author Report for: Lehner R

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    Title: Adipose tissue-specific ablation of Ces1d causes metabolic dysregulation in mice
    Li G, Li X, Yang L, Wang S, Dai Y, Fekry B, Veillon L, Tan L, Berdeaux R and Sun K <4 more author(s)>
    Ref: Life Sciences Alliance, 5:, 2022 : PubMed

            

    Title: Carboxylesterase 1d (Ces1d) does not contribute to cholesteryl ester hydrolysis in the liver
    Lian J, van der Veen JN, Watts R, Jacobs RL, Lehner R
    Ref: J Lipid Res, :100093, 2021 : PubMed

            

    Title: Effects of Chlorpyrifos on Serine Hydrolase Activities, Lipid Mediators, and Immune Responses in Lungs of Neonatal and Adult Mice
    Szafran BN, Borazjani A, Seay CN, Carr RL, Lehner R, Kaplan BLF, Ross MK
    Ref: Chemical Research in Toxicology, :, 2021 : PubMed

            

    Title: Ces1d deficiency protects against high-sucrose diet-induced hepatic triacylglycerol accumulation
    Lian J, Watts R, Quiroga AD, Beggs MR, Alexander RT, Lehner R
    Ref: J Lipid Res, 60:880, 2019 : PubMed

            

    Title: Carboxylesterases in lipid metabolism: from mouse to human
    Lian J, Nelson R, Lehner R
    Ref: Protein Cell, 9:178, 2018 : PubMed

            

    Title: Genetic variation in human carboxylesterase CES1 confers resistance to hepatic steatosis
    Lian J, Bahitham W, Panigrahi R, Nelson R, Li L, Watts R, Thiesen A, Lemieux MJ, Lehner R
    Ref: Biochimica & Biophysica Acta, 1863:688, 2018 : PubMed

            

    Title: Pharmacological intervention of liver triacylglycerol lipolysis: The good, the bad and the ugly
    Quiroga AD, Lehner R
    Ref: Biochemical Pharmacology, 155:233, 2018 : PubMed

            

    Title: Liver-specific expression of carboxylesterase 1g/esterase-x reduces hepatic steatosis, counteracts dyslipidemia and improves insulin signaling
    Bahitham W, Watts R, Nelson R, Lian J, Lehner R
    Ref: Biochimica & Biophysica Acta, 1861:482, 2016 : PubMed

            

    Title: Ces3/TGH Deficiency Attenuates Steatohepatitis
    Lian J, Wei E, Groenendyk J, Das SK, Hermansson M, Li L, Watts R, Thiesen A, Oudit GY and Lehner R <1 more author(s)>
    Ref: Sci Rep, 6:25747, 2016 : PubMed

            

    Title: Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation
    Lord CC, Ferguson D, Thomas G, Brown AL, Schugar RC, Burrows A, Gromovsky AD, Betters J, Neumann C and Brown JM <12 more author(s)>
    Ref: Cell Rep, 16:939, 2016 : PubMed

            

    Title: Endoplasmic reticulum-localized hepatic lipase decreases triacylglycerol storage and VLDL secretion
    Erickson B, Selvan SP, Ko KW, Kelly K, Quiroga AD, Li L, Nelson R, King-Jones K, Jacobs RL, Lehner R
    Ref: Biochimica & Biophysica Acta, 1831:1113, 2013 : PubMed

            

    Title: Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production
    Nourbakhsh M, Douglas DN, Pu CH, Lewis JT, Kawahara T, Lisboa LF, Wei E, Asthana S, Quiroga AD and Kneteman NM <6 more author(s)>
    Ref: Journal of Hepatology, 59:336, 2013 : PubMed

            

    Title: Ces3/TGH deficiency improves dyslipidemia and reduces atherosclerosis in Ldlr(-/-) mice
    Lian J, Quiroga AD, Li L, Lehner R
    Ref: Circulation Research, 111:982, 2012 : PubMed

            

    Title: Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice
    Lian J, Wei E, Wang SP, Quiroga AD, Li L, Pardo AD, van der Veen J, Sipione S, Mitchell GA and Di Pardo A <1 more author(s)>
    Ref: Hepatology, 56:2154, 2012 : PubMed

            

    Title: Carboxylesterase1/Esterase-x Regulates Chylomicron Production in Mice
    Quiroga AD, Lian J, Lehner R
    Ref: PLoS ONE, 7:e49515, 2012 : PubMed

            

    Title: Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia
    Quiroga AD, Li L, Trotzmuller M, Nelson R, Proctor SD, Kofeler H, Lehner R
    Ref: Hepatology, 56:2188, 2012 : PubMed

            

    Title: Liver triacylglycerol lipases
    Quiroga AD, Lehner R
    Ref: Biochimica & Biophysica Acta, 1821:762, 2012 : PubMed

            

    Title: Role of endoplasmic reticulum neutral lipid hydrolases
    Quiroga AD, Lehner R
    Ref: Trends Endocrinol Metab, 22:218, 2011 : PubMed

            

    Title: Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins
    Holmes RS, Wright MW, Laulederkind SJ, Cox LA, Hosokawa M, Imai T, Ishibashi S, Lehner R, Miyazaki M and Maltais LJ <9 more author(s)>
    Ref: Mamm Genome, 21:427, 2010 : PubMed

            

    Title: Arylacetamide deacetylase attenuates fatty-acid-induced triacylglycerol accumulation in rat hepatoma cells
    Lo V, Erickson B, Thomason-Hughes M, Ko KW, Dolinsky VW, Nelson R, Lehner R
    Ref: J Lipid Res, 51:368, 2010 : PubMed

            

    Title: Altered lipid droplet dynamics in hepatocytes lacking triacylglycerol hydrolase expression
    Wang H, Wei E, Quiroga AD, Sun X, Touret N, Lehner R
    Ref: Mol Biology of the cell, 21:1991, 2010 : PubMed

            

    Title: Loss of TGH/Ces3 in mice decreases blood lipids, improves glucose tolerance, and increases energy expenditure
    Wei E, Ben Ali Y, Lyon J, Wang H, Nelson R, Dolinsky VW, Dyck JR, Mitchell G, Korbutt GS, Lehner R
    Ref: Cell Metab, 11:183, 2010 : PubMed

            

    Title: Es-x/Ces1 prevents triacylglycerol accumulation in McArdle-RH7777 hepatocytes
    Ko KW, Erickson B, Lehner R
    Ref: Biochimica & Biophysica Acta, 1791:1133, 2009 : PubMed

            

    Title: Proteomic and lipid characterization of apolipoprotein B-free luminal lipid droplets from mouse liver microsomes: implications for very low density lipoprotein assembly
    Wang H, Gilham D, Lehner R
    Ref: Journal of Biological Chemistry, 282:33218, 2007 : PubMed

            

    Title: Attenuation of adipocyte triacylglycerol hydrolase activity decreases basal fatty acid efflux
    Wei E, Gao W, Lehner R
    Ref: Journal of Biological Chemistry, 282:8027, 2007 : PubMed

            

    Title: Mutation of F417 but not of L418 or L420 in the lipid binding domain decreases the activity of triacylglycerol hydrolase
    Alam M, Gilham D, Vance DE, Lehner R
    Ref: J Lipid Res, 47:375, 2006 : PubMed

            

    Title: Triacylglycerol hydrolase is localized to the endoplasmic reticulum by an unusual retrieval sequence where it participates in VLDL assembly without utilizing VLDL lipids as substrates
    Gilham D, Alam M, Gao W, Vance DE, Lehner R
    Ref: Mol Biology of the cell, 16:984, 2005 : PubMed

            

    Title: Insulin, glucagon and fatty acid treatment of hepatocytes does not result in phosphorylation or changes in activity of triacylglycerol hydrolase
    Gilham D, Perreault KR, Holmes CF, Brindley DN, Vance DE, Lehner R
    Ref: Biochimica & Biophysica Acta, 1736:189, 2005 : PubMed

            

    Title: Techniques to measure lipase and esterase activity in vitro
    Gilham D, Lehner R
    Ref: Methods, 36:139, 2005 : PubMed

            

    Title: C/EBPalpha activates the transcription of triacylglycerol hydrolase in 3T3-L1 adipocytes
    Wei E, Lehner R, Vance DE
    Ref: Biochemical Journal, 388:959, 2005 : PubMed

            

    Title: Triacylglycerol hydrolase: role in intracellular lipid metabolism
    Dolinsky VW, Gilham D, Alam M, Vance DE, Lehner R
    Ref: Cell Mol Life Sciences, 61:1633, 2004 : PubMed

            

    Title: Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone
    Dolinsky VW, Douglas DN, Lehner R, Vance DE
    Ref: Biochemical Journal, 378:967, 2004 : PubMed

            

    Title: The physiological role of triacylglycerol hydrolase in lipid metabolism
    Gilham D, Lehner R
    Ref: Rev Endocr Metab Disord, 5:303, 2004 : PubMed

            

    Title: Carboxylesterase 3 (EC 3.1.1.1) is a major adipocyte lipase
    Soni KG, Lehner R, Metalnikov P, O'Donnell P, Semache M, Gao W, Ashman K, Pshezhetsky AV, Mitchell GA
    Ref: Journal of Biological Chemistry, 279:40683, 2004 : PubMed

            

    Title: Regulation of triacylglycerol hydrolase expression by dietary fatty acids and peroxisomal proliferator-activated receptors
    Dolinsky VW, Gilham D, Hatch GM, Agellon LB, Lehner R, Vance DE
    Ref: Biochimica & Biophysica Acta, 1635:20, 2003 : PubMed

            

    Title: Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion
    Gilham D, Ho S, Rasouli M, Martres P, Vance DE, Lehner R
    Ref: FASEB Journal, 17:1685, 2003 : PubMed

            

    Title: Structure-function analysis of human triacylglycerol hydrolase by site-directed mutagenesis: identification of the catalytic triad and a glycosylation site
    Alam M, Vance DE, Lehner R
    Ref: Biochemistry, 41:6679, 2002 : PubMed

            

    Title: Heterologous expression, purification, and characterization of human triacylglycerol hydrolase
    Alam M, Ho S, Vance DE, Lehner R
    Ref: Protein Expr Purif, 24:33, 2002 : PubMed

            

    Title: The cloning and expression of a murine triacylglycerol hydrolase cDNA and the structure of its corresponding gene
    Dolinsky VW, Sipione S, Lehner R, Vance DE
    Ref: Biochimica & Biophysica Acta, 1532:162, 2001 : PubMed

            

    Title: A role for Sp1 in the transcriptional regulation of hepatic triacylglycerol hydrolase in the mouse
    Douglas DN, Dolinsky VW, Lehner R, Vance DE
    Ref: Journal of Biological Chemistry, 276:25621, 2001 : PubMed

            

    Title: Subcellullar localization, developmental expression and characterization of a liver triacylglycerol hydrolase
    Lehner R, Cui Z, Vance DE
    Ref: Biochemical Journal, 338 ( Pt 3):761, 1999 : PubMed

            

    Title: Cloning and expression of a cDNA encoding a hepatic microsomal lipase that mobilizes stored triacylglycerol
    Lehner R, Vance DE
    Ref: Biochemical Journal, 343 Pt 1:1, 1999 : PubMed

            

    Title: Purification and characterization of a porcine liver microsomal triacylglycerol hydrolase
    Lehner R, Verger R
    Ref: Biochemistry, 36:1861, 1997 : PubMed

            

    Title: Biosynthesis of triacylglycerols
    Lehner R, Kuksis A
    Ref: Prog Lipid Res, 35:169, 1996 : PubMed

            


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