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| Title : Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo - Mugnaini_2024_ACS.Chem.Neurosci__ |
| Author(s) : Mugnaini C , Brizzi A , Paolino M , Scarselli E , Castelli R , de Candia M , Gambacorta N , Nicolotti O , Kostrzewa M , Kumar P , Mahmoud AM , Borgonetti V , Iannotta M , Morace A , Galeotti N , Maione S , Altomare CD , Ligresti A , Corelli F |
| Ref : ACS Chem Neurosci , : , 2024 |
| Abstract : Mugnaini_2024_ACS.Chem.Neurosci__ |
| ESTHER : Mugnaini_2024_ACS.Chem.Neurosci__ |
| PubMedSearch : Mugnaini_2024_ACS.Chem.Neurosci__ |
| PubMedID: 38372253 |
| Title : Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization - Butini_2024_J.Med.Chem__ |
| Author(s) : Butini S , Grether U , Jung KM , Ligresti A , Allara M , Postmus AGJ , Maramai S , Brogi S , Papa A , Carullo G , Sykes D , Veprintsev D , Federico S , Grillo A , Di Guglielmo B , Ramunno A , Stevens AF , Heer D , Lamponi S , Gemma S , Benz J , Di Marzo V , van der Stelt M , Piomelli D , Campiani G |
| Ref : Journal of Medicinal Chemistry , : , 2024 |
| Abstract : Butini_2024_J.Med.Chem__ |
| ESTHER : Butini_2024_J.Med.Chem__ |
| PubMedSearch : Butini_2024_J.Med.Chem__ |
| PubMedID: 38241614 |
| Gene_locus related to this paper: human-MGLL |
| Title : New Coumarin Derivatives as Cholinergic and Cannabinoid System Modulators - Montanari_2021_Molecules_26_3254 |
| Author(s) : Montanari S , Allara M , Scalvini L , Kostrzewa M , Belluti F , Gobbi S , Naldi M , Rivara S , Bartolini M , Ligresti A , Bisi A , Rampa A |
| Ref : Molecules , 26 :3254 , 2021 |
| Abstract : Montanari_2021_Molecules_26_3254 |
| ESTHER : Montanari_2021_Molecules_26_3254 |
| PubMedSearch : Montanari_2021_Molecules_26_3254 |
| PubMedID: 34071439 |
| Title : Polyphenolic Profiling, Quantitative Assessment and Biological Activities of Tunisian Native Mentha rotundifolia (L.) Huds - Ben Haj Yahia_2019_Molecules_24_ |
| Author(s) : Ben Haj Yahia I , Zaouali Y , Ciavatta ML , Ligresti A , Jaouadi R , Boussaid M , Cutignano A |
| Ref : Molecules , 24 : , 2019 |
| Abstract : Ben Haj Yahia_2019_Molecules_24_ |
| ESTHER : Ben Haj Yahia_2019_Molecules_24_ |
| PubMedSearch : Ben Haj Yahia_2019_Molecules_24_ |
| PubMedID: 31247911 |
| Title : Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment - Montanari_2019_Eur.J.Med.Chem_178_243 |
| Author(s) : Montanari S , Mahmoud AM , Pruccoli L , Rabbito A , Naldi M , Petralla S , Moraleda I , Bartolini M , Monti B , Iriepa I , Belluti F , Gobbi S , Di Marzo V , Bisi A , Tarozzi A , Ligresti A , Rampa A |
| Ref : Eur Journal of Medicinal Chemistry , 178 :243 , 2019 |
| Abstract : Montanari_2019_Eur.J.Med.Chem_178_243 |
| ESTHER : Montanari_2019_Eur.J.Med.Chem_178_243 |
| PubMedSearch : Montanari_2019_Eur.J.Med.Chem_178_243 |
| PubMedID: 31185414 |
| Title : Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents - Montanari_2016_J.Med.Chem_59_6387 |
| Author(s) : Montanari S , Scalvini L , Bartolini M , Belluti F , Gobbi S , Andrisano V , Ligresti A , Di Marzo V , Rivara S , Mor M , Bisi A , Rampa A |
| Ref : Journal of Medicinal Chemistry , 59 :6387 , 2016 |
| Abstract : Montanari_2016_J.Med.Chem_59_6387 |
| ESTHER : Montanari_2016_J.Med.Chem_59_6387 |
| PubMedSearch : Montanari_2016_J.Med.Chem_59_6387 |
| PubMedID: 27309570 |
| Title : Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain - Brindisi_2016_J.Med.Chem_59_2612 |
| Author(s) : Brindisi M , Maramai S , Gemma S , Brogi S , Grillo A , Di Cesare Mannelli L , Gabellieri E , Lamponi S , Saponara S , Gorelli B , Tedesco D , Bonfiglio T , Landry C , Jung KM , Armirotti A , Luongo L , Ligresti A , Piscitelli F , Bertucci C , Dehouck MP , Campiani G , Maione S , Ghelardini C , Pittaluga A , Piomelli D , Di Marzo V , Butini S |
| Ref : Journal of Medicinal Chemistry , 59 :2612 , 2016 |
| Abstract : Brindisi_2016_J.Med.Chem_59_2612 |
| ESTHER : Brindisi_2016_J.Med.Chem_59_2612 |
| PubMedSearch : Brindisi_2016_J.Med.Chem_59_2612 |
| PubMedID: 26888301 |
| Title : Discovery of Glycine Sulfonamides as Dual Inhibitors of sn-1-Diacylglycerol Lipase alpha and alpha\/beta-Hydrolase Domain 6 - Janssen_2014_J.Med.Chem_57_6610 |
| Author(s) : Janssen FJ , Deng H , Baggelaar MP , Allara M , van der Wel T , den Dulk H , Ligresti A , van Esbroeck AC , McGuire R , Di Marzo V , Overkleeft HS , van der Stelt M |
| Ref : Journal of Medicinal Chemistry , 57 :6610 , 2014 |
| Abstract : Janssen_2014_J.Med.Chem_57_6610 |
| ESTHER : Janssen_2014_J.Med.Chem_57_6610 |
| PubMedSearch : Janssen_2014_J.Med.Chem_57_6610 |
| PubMedID: 24988361 |
| Title : Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring - Ortar_2013_Eur.J.Med.Chem_63_118 |
| Author(s) : Ortar G , Morera E , De Petrocellis L , Ligresti A , Schiano Moriello A , Morera L , Nalli M , Ragno R , Pirolli A , Di Marzo V |
| Ref : Eur Journal of Medicinal Chemistry , 63 :118 , 2013 |
| Abstract : Ortar_2013_Eur.J.Med.Chem_63_118 |
| ESTHER : Ortar_2013_Eur.J.Med.Chem_63_118 |
| PubMedSearch : Ortar_2013_Eur.J.Med.Chem_63_118 |
| PubMedID: 23474898 |
| Title : The First Dual ChE\/FAAH Inhibitors: New Perspectives for Alzheimer's Disease? - Rampa_2012_ACS.Med.Chem.Lett_3_182 |
| Author(s) : Rampa A , Bartolini M , Bisi A , Belluti F , Gobbi S , Andrisano V , Ligresti A , Di Marzo V |
| Ref : ACS Med Chem Lett , 3 :182 , 2012 |
| Abstract : Rampa_2012_ACS.Med.Chem.Lett_3_182 |
| ESTHER : Rampa_2012_ACS.Med.Chem.Lett_3_182 |
| PubMedSearch : Rampa_2012_ACS.Med.Chem.Lett_3_182 |
| PubMedID: 24900454 |
| Title : Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism - Ortar_2008_J.Med.Chem_51_6970 |
| Author(s) : Ortar G , Bisogno T , Ligresti A , Morera E , Nalli M , Di Marzo V |
| Ref : Journal of Medicinal Chemistry , 51 :6970 , 2008 |
| Abstract : Ortar_2008_J.Med.Chem_51_6970 |
| ESTHER : Ortar_2008_J.Med.Chem_51_6970 |
| PubMedSearch : Ortar_2008_J.Med.Chem_51_6970 |
| PubMedID: 18831576 |
| Title : Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non-cannabinoid receptor-mediated mechanisms - Maione_2008_Br.J.Pharmacol_155_775 |
| Author(s) : Maione S , Morera E , Marabese I , Ligresti A , Luongo L , Ortar G , Di Marzo V |
| Ref : British Journal of Pharmacology , 155 :775 , 2008 |
| Abstract : Maione_2008_Br.J.Pharmacol_155_775 |
| ESTHER : Maione_2008_Br.J.Pharmacol_155_775 |
| PubMedSearch : Maione_2008_Br.J.Pharmacol_155_775 |
| PubMedID: 18660824 |
| Title : Endocannabinoid metabolic pathways and enzymes - Ligresti_2005_Curr.Drug.Targets.CNS.Neurol.Disord_4_615 |
| Author(s) : Ligresti A , Cascio MG , Di Marzo V |
| Ref : Curr Drug Targets CNS Neurol Disord , 4 :615 , 2005 |
| Abstract : Ligresti_2005_Curr.Drug.Targets.CNS.Neurol.Disord_4_615 |
| ESTHER : Ligresti_2005_Curr.Drug.Targets.CNS.Neurol.Disord_4_615 |
| PubMedSearch : Ligresti_2005_Curr.Drug.Targets.CNS.Neurol.Disord_4_615 |
| PubMedID: 16375679 |
| Title : Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain - Bisogno_2003_J.Cell.Biol_163_463 |
| Author(s) : Bisogno T , Howell F , Williams G , Minassi A , Cascio MG , Ligresti A , Matias I , Schiano-Moriello A , Paul P , Williams EJ , Gangadharan U , Hobbs C , Di Marzo V , Doherty P |
| Ref : Journal of Cell Biology , 163 :463 , 2003 |
| Abstract : Bisogno_2003_J.Cell.Biol_163_463 |
| ESTHER : Bisogno_2003_J.Cell.Biol_163_463 |
| PubMedSearch : Bisogno_2003_J.Cell.Biol_163_463 |
| PubMedID: 14610053 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB , mouse-DGLB , mouse-q6wqj1 |