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| Title : M(1)\/M(4)-Preferring Muscarinic Cholinergic Receptor Agonist Xanomeline Reverses Wake and Arousal Deficits in Nonpathologically Aged Mice - Russell_2023_ACS.Chem.Neurosci__ |
| Author(s) : Russell JK , Ingram SM , Teal LB , Lindsley CW , Jones CK |
| Ref : ACS Chem Neurosci , : , 2023 |
| Abstract : Russell_2023_ACS.Chem.Neurosci__ |
| ESTHER : Russell_2023_ACS.Chem.Neurosci__ |
| PubMedSearch : Russell_2023_ACS.Chem.Neurosci__ |
| PubMedID: 36655909 |
| Title : Examining the role of muscarinic M5 receptors in VTA cholinergic modulation of depressive-like and anxiety-related behaviors in rats - Nunes_2020_Neuropharmacol__108089 |
| Author(s) : Nunes EJ , Rupprecht LE , Foster DJ , Lindsley CW , Conn PJ , Addy NA |
| Ref : Neuropharmacology , :108089 , 2020 |
| Abstract : Nunes_2020_Neuropharmacol__108089 |
| ESTHER : Nunes_2020_Neuropharmacol__108089 |
| PubMedSearch : Nunes_2020_Neuropharmacol__108089 |
| PubMedID: 32268153 |
| Title : Modulation of arousal and sleep\/wake architecture by M(1) PAM VU0453595 across young and aged rodents and nonhuman primates - Gould_2020_Neuropsychopharmacology_45_2219 |
| Author(s) : Gould RW , Russell JK , Nedelcovych MT , Bubser M , Blobaum AL , Bridges TM , Newhouse PA , Lindsley CW , Conn PJ , Nader MA , Jones CK |
| Ref : Neuropsychopharmacology , 45 :2219 , 2020 |
| Abstract : Gould_2020_Neuropsychopharmacology_45_2219 |
| ESTHER : Gould_2020_Neuropsychopharmacology_45_2219 |
| PubMedSearch : Gould_2020_Neuropsychopharmacology_45_2219 |
| PubMedID: 32868847 |
| Title : Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound - Bertron_2016_Bioorg.Med.Chem.Lett_26_4637 |
| Author(s) : Bertron JL , Ennis EA , Tarr CJ , Wright J , Dickerson JW , Locuson CW , Blobaum AL , Rook JM , Blakely RD , Lindsley CW |
| Ref : Bioorganic & Medicinal Chemistry Lett , 26 :4637 , 2016 |
| Abstract : Bertron_2016_Bioorg.Med.Chem.Lett_26_4637 |
| ESTHER : Bertron_2016_Bioorg.Med.Chem.Lett_26_4637 |
| PubMedSearch : Bertron_2016_Bioorg.Med.Chem.Lett_26_4637 |
| PubMedID: 27575469 |
| Title : Identification and Characterization of ML352: A Novel, Noncompetitive Inhibitor of the Presynaptic Choline Transporter - Ennis_2015_ACS.Chem.Neurosci_6_417 |
| Author(s) : Ennis EA , Wright J , Retzlaff CL , McManus OB , Lin Z , Huang X , Wu M , Li M , Daniels JS , Lindsley CW , Hopkins CR , Blakely RD |
| Ref : ACS Chem Neurosci , 6 :417 , 2015 |
| Abstract : Ennis_2015_ACS.Chem.Neurosci_6_417 |
| ESTHER : Ennis_2015_ACS.Chem.Neurosci_6_417 |
| PubMedSearch : Ennis_2015_ACS.Chem.Neurosci_6_417 |
| PubMedID: 25560927 |
| Title : M4 mAChR-Mediated Modulation of Glutamatergic Transmission at Corticostriatal Synapses - Pancani_2014_ACS.Chem.Neurosci_5_318 |
| Author(s) : Pancani T , Bolarinwa C , Smith Y , Lindsley CW , Conn PJ , Xiang Z |
| Ref : ACS Chem Neurosci , 5 :318 , 2014 |
| Abstract : Pancani_2014_ACS.Chem.Neurosci_5_318 |
| ESTHER : Pancani_2014_ACS.Chem.Neurosci_5_318 |
| PubMedSearch : Pancani_2014_ACS.Chem.Neurosci_5_318 |
| PubMedID: 24528004 |
| Title : Chemical modulation of glycerolipid signaling and metabolic pathways - Scott_2014_Biochim.Biophys.Acta_1841_1060 |
| Author(s) : Scott SA , Mathews TP , Ivanova PT , Lindsley CW , Brown HA |
| Ref : Biochimica & Biophysica Acta , 1841 :1060 , 2014 |
| Abstract : Scott_2014_Biochim.Biophys.Acta_1841_1060 |
| ESTHER : Scott_2014_Biochim.Biophys.Acta_1841_1060 |
| PubMedSearch : Scott_2014_Biochim.Biophys.Acta_1841_1060 |
| PubMedID: 24440821 |
| Title : Roles of the M1 muscarinic acetylcholine receptor subtype in the regulation of basal ganglia function and implications for the treatment of Parkinson's disease - Xiang_2012_J.Pharmacol.Exp.Ther_340_595 |
| Author(s) : Xiang Z , Thompson AD , Jones CK , Lindsley CW , Conn PJ |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 340 :595 , 2012 |
| Abstract : Xiang_2012_J.Pharmacol.Exp.Ther_340_595 |
| ESTHER : Xiang_2012_J.Pharmacol.Exp.Ther_340_595 |
| PubMedSearch : Xiang_2012_J.Pharmacol.Exp.Ther_340_595 |
| PubMedID: 22135383 |
| Title : Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models - Digby_2012_J.Neurosci_32_8532 |
| Author(s) : Digby GJ , Noetzel MJ , Bubser M , Utley TJ , Walker AG , Byun NE , LeBois EP , Xiang Z , Sheffler DJ , Cho HP , Davis AA , Nemirovsky NE , Mennenga SE , Camp BW , Bimonte-Nelson HA , Bode J , Italiano K , Morrison R , Daniels JS , Niswender CM , Olive MF , Lindsley CW , Jones CK , Conn PJ |
| Ref : Journal of Neuroscience , 32 :8532 , 2012 |
| Abstract : Digby_2012_J.Neurosci_32_8532 |
| ESTHER : Digby_2012_J.Neurosci_32_8532 |
| PubMedSearch : Digby_2012_J.Neurosci_32_8532 |
| PubMedID: 22723693 |
| Title : Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012 - Melancon_2012_Bioorg.Med.Chem.Lett_22_1044 |
| Author(s) : Melancon BJ , Lamers AP , Bridges TM , Sulikowski GA , Utley TJ , Sheffler DJ , Noetzel MJ , Morrison RD , Daniels JS , Niswender CM , Jones CK , Conn PJ , Lindsley CW , Wood MR |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :1044 , 2012 |
| Abstract : Melancon_2012_Bioorg.Med.Chem.Lett_22_1044 |
| ESTHER : Melancon_2012_Bioorg.Med.Chem.Lett_22_1044 |
| PubMedSearch : Melancon_2012_Bioorg.Med.Chem.Lett_22_1044 |
| PubMedID: 22197142 |
| Title : Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor - Salovich_2012_Bioorg.Med.Chem.Lett_22_5084 |
| Author(s) : Salovich JM , Vinson PN , Sheffler DJ , Lamsal A , Utley TJ , Blobaum AL , Bridges TM , Le U , Jones CK , Wood MR , Daniels JS , Conn PJ , Niswender CM , Lindsley CW , Hopkins CR |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :5084 , 2012 |
| Abstract : Salovich_2012_Bioorg.Med.Chem.Lett_22_5084 |
| ESTHER : Salovich_2012_Bioorg.Med.Chem.Lett_22_5084 |
| PubMedSearch : Salovich_2012_Bioorg.Med.Chem.Lett_22_5084 |
| PubMedID: 22738637 |
| Title : Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery - |
| Author(s) : Melancon BJ , Hopkins CR , Wood MR , Emmitte KA , Niswender CM , Christopoulos A , Conn PJ , Lindsley CW |
| Ref : Journal of Medicinal Chemistry , 55 :1445 , 2012 |
| PubMedID: 22148748 |
| Title : The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease - Jones_2012_J.Pharmacol.Exp.Ther_340_404 |
| Author(s) : Jones CK , Bubser M , Thompson AD , Dickerson JW , Turle-Lorenzo N , Amalric M , Blobaum AL , Bridges TM , Morrison RD , Jadhav S , Engers DW , Italiano K , Bode J , Daniels JS , Lindsley CW , Hopkins CR , Conn PJ , Niswender CM |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 340 :404 , 2012 |
| Abstract : Jones_2012_J.Pharmacol.Exp.Ther_340_404 |
| ESTHER : Jones_2012_J.Pharmacol.Exp.Ther_340_404 |
| PubMedSearch : Jones_2012_J.Pharmacol.Exp.Ther_340_404 |
| PubMedID: 22088953 |
| Title : Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe - Reid_2011_Bioorg.Med.Chem.Lett_21_2697 |
| Author(s) : Reid PR , Bridges TM , Sheffler DJ , Cho HP , Lewis LM , Days E , Daniels JS , Jones CK , Niswender CM , Weaver CD , Conn PJ , Lindsley CW , Wood MR |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :2697 , 2011 |
| Abstract : Reid_2011_Bioorg.Med.Chem.Lett_21_2697 |
| ESTHER : Reid_2011_Bioorg.Med.Chem.Lett_21_2697 |
| PubMedSearch : Reid_2011_Bioorg.Med.Chem.Lett_21_2697 |
| PubMedID: 21194936 |
| Title : The evolution of histamine H(3) antagonists\/inverse agonists - Lebois_2011_Curr.Top.Med.Chem_11_648 |
| Author(s) : LeBois EP , Jones CK , Lindsley CW |
| Ref : Curr Top Med Chem , 11 :648 , 2011 |
| Abstract : Lebois_2011_Curr.Top.Med.Chem_11_648 |
| ESTHER : Lebois_2011_Curr.Top.Med.Chem_11_648 |
| PubMedSearch : Lebois_2011_Curr.Top.Med.Chem_11_648 |
| PubMedID: 21261594 |
| Title : Differential effects of allosteric M(1) muscarinic acetylcholine receptor agonists on receptor activation, arrestin 3 recruitment, and receptor downregulation - Davis_2010_ACS.Chem.Neurosci_1_542 |
| Author(s) : Davis AA , Heilman CJ , Brady AE , Miller NR , Fuerstenau-Sharp M , Hanson BJ , Lindsley CW , Conn PJ , Lah JJ , Levey AI |
| Ref : ACS Chem Neurosci , 1 :542 , 2010 |
| Abstract : Davis_2010_ACS.Chem.Neurosci_1_542 |
| ESTHER : Davis_2010_ACS.Chem.Neurosci_1_542 |
| PubMedSearch : Davis_2010_ACS.Chem.Neurosci_1_542 |
| PubMedID: 20835371 |
| Title : Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system - Lebois_2010_ACS.Chem.Neurosci_1_104 |
| Author(s) : LeBois EP , Bridges TM , Lewis LM , Dawson ES , Kane AS , Xiang Z , Jadhav SB , Yin H , Kennedy JP , Meiler J , Niswender CM , Jones CK , Conn PJ , Weaver CD , Lindsley CW |
| Ref : ACS Chem Neurosci , 1 :104 , 2010 |
| Abstract : Lebois_2010_ACS.Chem.Neurosci_1_104 |
| ESTHER : Lebois_2010_ACS.Chem.Neurosci_1_104 |
| PubMedSearch : Lebois_2010_ACS.Chem.Neurosci_1_104 |
| PubMedID: 21961051 |
| Title : The antipsychotic potential of muscarinic allosteric modulation - Bridges_2010_Drug.News.Perspect_23_229 |
| Author(s) : Bridges TM , LeBois EP , Hopkins CR , Wood MR , Jones CK , Conn PJ , Lindsley CW |
| Ref : Drug News Perspect , 23 :229 , 2010 |
| Abstract : Bridges_2010_Drug.News.Perspect_23_229 |
| ESTHER : Bridges_2010_Drug.News.Perspect_23_229 |
| PubMedSearch : Bridges_2010_Drug.News.Perspect_23_229 |
| PubMedID: 20520852 |
| Title : Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe - Weaver_2009_Curr.Top.Med.Chem_9_1217 |
| Author(s) : Weaver CD , Sheffler DJ , Lewis LM , Bridges TM , Williams R , Nalywajko NT , Kennedy JP , Mulder MM , Jadhav S , Aldrich LA , Jones CK , Marlo JE , Niswender CM , Mock MM , Zheng F , Conn PJ , Lindsley CW |
| Ref : Curr Top Med Chem , 9 :1217 , 2009 |
| Abstract : Weaver_2009_Curr.Top.Med.Chem_9_1217 |
| ESTHER : Weaver_2009_Curr.Top.Med.Chem_9_1217 |
| PubMedSearch : Weaver_2009_Curr.Top.Med.Chem_9_1217 |
| PubMedID: 19807667 |
| Title : Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders - Conn_2009_Trends.Pharmacol.Sci_30_148 |
| Author(s) : Conn PJ , Jones CK , Lindsley CW |
| Ref : Trends in Pharmacological Sciences , 30 :148 , 2009 |
| Abstract : Conn_2009_Trends.Pharmacol.Sci_30_148 |
| ESTHER : Conn_2009_Trends.Pharmacol.Sci_30_148 |
| PubMedSearch : Conn_2009_Trends.Pharmacol.Sci_30_148 |
| PubMedID: 19201489 |
| Title : A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning - Shirey_2009_J.Neurosci_29_14271 |
| Author(s) : Shirey JK , Brady AE , Jones PJ , Davis AA , Bridges TM , Kennedy JP , Jadhav SB , Menon UN , Xiang Z , Watson ML , Christian EP , Doherty JJ , Quirk MC , Snyder DH , Lah JJ , Levey AI , Nicolle MM , Lindsley CW , Conn PJ |
| Ref : Journal of Neuroscience , 29 :14271 , 2009 |
| Abstract : Shirey_2009_J.Neurosci_29_14271 |
| ESTHER : Shirey_2009_J.Neurosci_29_14271 |
| PubMedSearch : Shirey_2009_J.Neurosci_29_14271 |
| PubMedID: 19906975 |
| Title : A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning - Sheffler_2009_Mol.Pharmacol_76_356 |
| Author(s) : Sheffler DJ , Williams R , Bridges TM , Xiang Z , Kane AS , Byun NE , Jadhav S , Mock MM , Zheng F , Lewis LM , Jones CK , Niswender CM , Weaver CD , Lindsley CW , Conn PJ |
| Ref : Molecular Pharmacology , 76 :356 , 2009 |
| Abstract : Sheffler_2009_Mol.Pharmacol_76_356 |
| ESTHER : Sheffler_2009_Mol.Pharmacol_76_356 |
| PubMedSearch : Sheffler_2009_Mol.Pharmacol_76_356 |
| PubMedID: 19407080 |
| Title : Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor - |
| Author(s) : Kennedy JP , Bridges TM , Gentry PR , Brogan JT , Kane AS , Jones CK , Brady AE , Shirey JK , Conn PJ , Lindsley CW |
| Ref : ChemMedChem , 4 :1600 , 2009 |
| PubMedID: 19705385 |
| Title : Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity - Marlo_2009_Mol.Pharmacol_75_577 |
| Author(s) : Marlo JE , Niswender CM , Days EL , Bridges TM , Xiang Y , Rodriguez AL , Shirey JK , Brady AE , Nalywajko T , Luo Q , Austin CA , Williams MB , Kim K , Williams R , Orton D , Brown HA , Lindsley CW , Weaver CD , Conn PJ |
| Ref : Molecular Pharmacology , 75 :577 , 2009 |
| Abstract : Marlo_2009_Mol.Pharmacol_75_577 |
| ESTHER : Marlo_2009_Mol.Pharmacol_75_577 |
| PubMedSearch : Marlo_2009_Mol.Pharmacol_75_577 |
| PubMedID: 19047481 |
| Title : Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins - Bridges_2009_J.Med.Chem_52_3445 |
| Author(s) : Bridges TM , Marlo JE , Niswender CM , Jones CK , Jadhav SB , Gentry PR , Plumley HC , Weaver CD , Conn PJ , Lindsley CW |
| Ref : Journal of Medicinal Chemistry , 52 :3445 , 2009 |
| Abstract : Bridges_2009_J.Med.Chem_52_3445 |
| ESTHER : Bridges_2009_J.Med.Chem_52_3445 |
| PubMedSearch : Bridges_2009_J.Med.Chem_52_3445 |
| PubMedID: 19438238 |
| Title : Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen - Miller_2008_Bioorg.Med.Chem.Lett_18_5443 |
| Author(s) : Miller NR , Daniels RN , Bridges TM , Brady AE , Conn PJ , Lindsley CW |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :5443 , 2008 |
| Abstract : Miller_2008_Bioorg.Med.Chem.Lett_18_5443 |
| ESTHER : Miller_2008_Bioorg.Med.Chem.Lett_18_5443 |
| PubMedSearch : Miller_2008_Bioorg.Med.Chem.Lett_18_5443 |
| PubMedID: 18829311 |
| Title : Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats - Jones_2008_J.Neurosci_28_10422 |
| Author(s) : Jones CK , Brady AE , Davis AA , Xiang Z , Bubser M , Tantawy MN , Kane AS , Bridges TM , Kennedy JP , Bradley SR , Peterson TE , Ansari MS , Baldwin RM , Kessler RM , Deutch AY , Lah JJ , Levey AI , Lindsley CW , Conn PJ |
| Ref : Journal of Neuroscience , 28 :10422 , 2008 |
| Abstract : Jones_2008_J.Neurosci_28_10422 |
| ESTHER : Jones_2008_J.Neurosci_28_10422 |
| PubMedSearch : Jones_2008_J.Neurosci_28_10422 |
| PubMedID: 18842902 |
| Title : Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats - Brady_2008_J.Pharmacol.Exp.Ther_327_941 |
| Author(s) : Brady AE , Jones CK , Bridges TM , Kennedy JP , Thompson AD , Heiman JU , Breininger ML , Gentry PR , Yin H , Jadhav SB , Shirey JK , Conn PJ , Lindsley CW |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 327 :941 , 2008 |
| Abstract : Brady_2008_J.Pharmacol.Exp.Ther_327_941 |
| ESTHER : Brady_2008_J.Pharmacol.Exp.Ther_327_941 |
| PubMedSearch : Brady_2008_J.Pharmacol.Exp.Ther_327_941 |
| PubMedID: 18772318 |
| Title : Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties - Bridges_2008_Bioorg.Med.Chem.Lett_18_5439 |
| Author(s) : Bridges TM , Brady AE , Kennedy JP , Daniels RN , Miller NR , Kim K , Breininger ML , Gentry PR , Brogan JT , Jones CK , Conn PJ , Lindsley CW |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :5439 , 2008 |
| Abstract : Bridges_2008_Bioorg.Med.Chem.Lett_18_5439 |
| ESTHER : Bridges_2008_Bioorg.Med.Chem.Lett_18_5439 |
| PubMedSearch : Bridges_2008_Bioorg.Med.Chem.Lett_18_5439 |
| PubMedID: 18805692 |