Full name :
First name :
Mail :
Zip Code :
City :
Country :
Email :
Phone :
Fax :
Website :
Directory :
| Title : Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors - Zhao_2013_Bioorg.Med.Chem.Lett_23_1622 |
| Author(s) : Zhao G , Kwon C , Wang A , Robertson JG , Marcinkeviciene J , Parker RA , Kirby MS , Hamann LG |
| Ref : Bioorganic & Medicinal Chemistry Lett , 23 :1622 , 2013 |
| Abstract : Zhao_2013_Bioorg.Med.Chem.Lett_23_1622 |
| ESTHER : Zhao_2013_Bioorg.Med.Chem.Lett_23_1622 |
| PubMedSearch : Zhao_2013_Bioorg.Med.Chem.Lett_23_1622 |
| PubMedID: 23416006 |
| Title : Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor - Wang_2012_BMC.Pharmacol_12_2 |
| Author(s) : Wang A , Dorso C , Kopcho L , Locke G , Langish R , Harstad E , Shipkova P , Marcinkeviciene J , Hamann L , Kirby MS |
| Ref : BMC Pharmacol , 12 :2 , 2012 |
| Abstract : Wang_2012_BMC.Pharmacol_12_2 |
| ESTHER : Wang_2012_BMC.Pharmacol_12_2 |
| PubMedSearch : Wang_2012_BMC.Pharmacol_12_2 |
| PubMedID: 22475049 |
| Title : Discovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxa mides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors - Meng_2010_J.Med.Chem_53_5620 |
| Author(s) : Meng W , Brigance RP , Chao HJ , Fura A , Harrity T , Marcinkeviciene J , O'Connor SP , Tamura JK , Xie D , Zhang Y , Klei HE , Kish K , Weigelt CA , Turdi H , Wang A , Zahler R , Kirby MS , Hamann LG |
| Ref : Journal of Medicinal Chemistry , 53 :5620 , 2010 |
| Abstract : Meng_2010_J.Med.Chem_53_5620 |
| ESTHER : Meng_2010_J.Med.Chem_53_5620 |
| PubMedSearch : Meng_2010_J.Med.Chem_53_5620 |
| PubMedID: 20684603 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation - Metzler_2008_Protein.Sci_17_240 |
| Author(s) : Metzler WJ , Yanchunas J , Weigelt C , Kish K , Klei HE , Xie D , Zhang Y , Corbett M , Tamura JK , He B , Hamann LG , Kirby MS , Marcinkeviciene J |
| Ref : Protein Science , 17 :240 , 2008 |
| Abstract : Metzler_2008_Protein.Sci_17_240 |
| ESTHER : Metzler_2008_Protein.Sci_17_240 |
| PubMedSearch : Metzler_2008_Protein.Sci_17_240 |
| PubMedID: 18227430 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors - Simpkins_2007_Bioorg.Med.Chem.Lett_17_6476 |
| Author(s) : Simpkins LM , Bolton S , Pi Z , Sutton JC , Kwon C , Zhao G , Magnin DR , Augeri DJ , Gungor T , Rotella DP , Sun Z , Liu Y , Slusarchyk WS , Marcinkeviciene J , Robertson JG , Wang A , Robl JA , Atwal KS , Zahler RL , Parker RA , Kirby MS , Hamann LG |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :6476 , 2007 |
| Abstract : Simpkins_2007_Bioorg.Med.Chem.Lett_17_6476 |
| ESTHER : Simpkins_2007_Bioorg.Med.Chem.Lett_17_6476 |
| PubMedSearch : Simpkins_2007_Bioorg.Med.Chem.Lett_17_6476 |
| PubMedID: 17937986 |
| Title : Seco-prolinenitrile inhibitors of dipeptidyl peptidase IV define minimal pharmacophore requirements at P1 - Magnin_2006_Bioorg.Med.Chem.Lett_16_1731 |
| Author(s) : Magnin DR , Taunk PC , Robertson JG , Wang A , Marcinkeviciene J , Kirby MS , Hamann LG |
| Ref : Bioorganic & Medicinal Chemistry Lett , 16 :1731 , 2006 |
| Abstract : Magnin_2006_Bioorg.Med.Chem.Lett_16_1731 |
| ESTHER : Magnin_2006_Bioorg.Med.Chem.Lett_16_1731 |
| PubMedSearch : Magnin_2006_Bioorg.Med.Chem.Lett_16_1731 |
| PubMedID: 16376077 |
| Title : Probing prime substrate binding sites of human dipeptidyl peptidase-IV using competitive substrate approach - Kopcho_2005_Arch.Biochem.Biophys_436_367 |
| Author(s) : Kopcho LM , Kim YB , Wang A , Liu MA , Kirby MS , Marcinkeviciene J |
| Ref : Archives of Biochemistry & Biophysics , 436 :367 , 2005 |
| Abstract : Kopcho_2005_Arch.Biochem.Biophys_436_367 |
| ESTHER : Kopcho_2005_Arch.Biochem.Biophys_436_367 |
| PubMedSearch : Kopcho_2005_Arch.Biochem.Biophys_436_367 |
| PubMedID: 15797249 |
| Title : Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Augeri_2005_J.Med.Chem_48_5025 |
| Author(s) : Augeri DJ , Robl JA , Betebenner DA , Magnin DR , Khanna A , Robertson JG , Wang A , Simpkins LM , Taunk P , Huang Q , Han SP , Abboa-Offei B , Cap M , Xin L , Tao L , Tozzo E , Welzel GE , Egan DM , Marcinkeviciene J , Chang SY , Biller SA , Kirby MS , Parker RA , Hamann LG |
| Ref : Journal of Medicinal Chemistry , 48 :5025 , 2005 |
| Abstract : Augeri_2005_J.Med.Chem_48_5025 |
| ESTHER : Augeri_2005_J.Med.Chem_48_5025 |
| PubMedSearch : Augeri_2005_J.Med.Chem_48_5025 |
| PubMedID: 16033281 |
| Title : Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors - Zhao_2005_Bioorg.Med.Chem.Lett_15_3992 |
| Author(s) : Zhao G , Taunk PC , Magnin DR , Simpkins LM , Robl JA , Wang A , Robertson JG , Marcinkeviciene J , Sitkoff DF , Parker RA , Kirby MS , Hamann LG |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :3992 , 2005 |
| Abstract : Zhao_2005_Bioorg.Med.Chem.Lett_15_3992 |
| ESTHER : Zhao_2005_Bioorg.Med.Chem.Lett_15_3992 |
| PubMedSearch : Zhao_2005_Bioorg.Med.Chem.Lett_15_3992 |
| PubMedID: 16046120 |